SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1fts FTSY
(Escherichia
coli) 		4 / 6 ILE A 249
GLU A 230
LEU A 217
LEU A 267
 None
 1.02A 1mt1B-1ftsA:
0.0
1mt1C-1ftsA:
0.0		 1mt1B-1ftsA:
15.93
1mt1C-1ftsA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1fts FTSY
(Escherichia
coli) 		4 / 5 LEU A 235
GLY A 455
ILE A 278
ILE A 248
 None
 0.87A 2q9rA-1ftsA:
1.0		 2q9rA-1ftsA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1fts FTSY
(Escherichia
coli) 		4 / 6 LEU A 480
VAL A 428
VAL A 304
ILE A 443
 None
 1.23A 3k5vB-1ftsA:
undetectable		 3k5vB-1ftsA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1fts FTSY
(Escherichia
coli) 		3 / 3 GLY A 303
GLY A 305
THR A 307
 None
 0.45A 3si7B-1ftsA:
2.0		 3si7B-1ftsA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 1fts FTSY
(Escherichia
coli) 		5 / 12 THR A 307
ILE A 310
ILE A 376
ALA A 370
VAL A 337
 None
 1.24A 3vw1D-1ftsA:
0.0		 3vw1D-1ftsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1fts FTSY
(Escherichia
coli) 		4 / 6 ILE A 376
VAL A 295
LEU A 297
ILE A 380
 None
 0.80A 4asdA-1ftsA:
undetectable		 4asdA-1ftsA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1fts FTSY
(Escherichia
coli) 		4 / 6 PHE A 214
GLY A 455
LEU A 235
VAL A 240
 None
 1.06A 4dubA-1ftsA:
0.1		 4dubA-1ftsA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 1fts FTSY
(Escherichia
coli) 		5 / 12 LEU A 480
GLY A 472
VAL A 304
ILE A 457
VAL A 456
 None
 1.16A 4okwA-1ftsA:
1.0		 4okwA-1ftsA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1fts FTSY
(Escherichia
coli) 		5 / 12 ILE A 443
ALA A 431
GLN A 430
THR A 423
LEU A 445
 None
 1.09A 4qzuA-1ftsA:
0.2		 4qzuA-1ftsA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1fts FTSY
(Escherichia
coli) 		5 / 9 ALA A 437
ASN A 302
VAL A 304
GLY A 385
THR A 383
 None
 1.28A 4r20B-1ftsA:
undetectable		 4r20B-1ftsA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 1fts FTSY
(Escherichia
coli) 		5 / 12 ILE A 368
VAL A 363
ASP A 382
THR A 383
ILE A 400
 None
 1.31A 4xe0A-1ftsA:
undetectable		 4xe0A-1ftsA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1fts FTSY
(Escherichia
coli) 		5 / 11 GLN A 234
GLY A 454
THR A 206
ALA A 452
THR A 451
 None
 1.23A 5bxnH-1ftsA:
undetectable
5bxnI-1ftsA:
undetectable		 5bxnH-1ftsA:
24.82
5bxnI-1ftsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1fts FTSY
(Escherichia
coli) 		4 / 8 LEU A 210
PHE A 493
ILE A 489
PHE A 214
 None
 0.83A 5eseA-1ftsA:
undetectable		 5eseA-1ftsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 1fts FTSY
(Escherichia
coli) 		3 / 3 HIS A 435
LYS A 432
PHE A 464
 None
 1.48A 5klaA-1ftsA:
undetectable		 5klaA-1ftsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1fts FTSY
(Escherichia
coli) 		5 / 12 GLN A 234
GLY A 454
THR A 206
ALA A 452
THR A 451
 None
 1.13A 5l5fH-1ftsA:
undetectable
5l5fI-1ftsA:
undetectable		 5l5fH-1ftsA:
24.47
5l5fI-1ftsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1fts FTSY
(Escherichia
coli) 		5 / 12 GLN A 234
GLY A 454
THR A 206
ALA A 452
THR A 451
 None
 1.13A 5l5fV-1ftsA:
undetectable
5l5fW-1ftsA:
undetectable		 5l5fV-1ftsA:
24.47
5l5fW-1ftsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1fts FTSY
(Escherichia
coli) 		5 / 12 GLN A 234
GLY A 454
THR A 206
ALA A 452
THR A 451
 None
 1.09A 5l66H-1ftsA:
undetectable
5l66I-1ftsA:
undetectable		 5l66H-1ftsA:
24.47
5l66I-1ftsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1fts FTSY
(Escherichia
coli) 		5 / 12 GLN A 234
GLY A 454
THR A 206
ALA A 452
THR A 451
 None
 1.09A 5l66V-1ftsA:
undetectable
5l66W-1ftsA:
undetectable		 5l66V-1ftsA:
24.47
5l66W-1ftsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1fts FTSY
(Escherichia
coli) 		3 / 3 GLU A 396
HIS A 392
ARG A 386
 None
 0.87A 5uunA-1ftsA:
0.0		 5uunA-1ftsA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1fts FTSY
(Escherichia
coli) 		5 / 12 ILE A 457
GLY A 424
ALA A 427
ASP A 420
ILE A 443
 None
 1.12A 6dwnD-1ftsA:
undetectable		 6dwnD-1ftsA:
13.33