SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fu1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		5 / 8 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.90A 1d4sB-1fu1A:
0.0		 1d4sB-1fu1A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		5 / 11 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.87A 1t7jA-1fu1A:
undetectable		 1t7jA-1fu1A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		5 / 8 ARG A  71
LEU A  75
ILE A  34
GLY A 109
LEU A  28
 None
None
None
ACY  A 503 (-3.5A)
None
 1.47A 2o4nB-1fu1A:
undetectable		 2o4nB-1fu1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		4 / 8 GLY A  39
HIS A  40
ILE A 127
ALA A  42
 None
None
CAS  A 128 ( 3.9A)
None
 0.91A 2x0pA-1fu1A:
2.1		 2x0pA-1fu1A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		5 / 12 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.80A 3gguA-1fu1A:
undetectable		 3gguA-1fu1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		5 / 12 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.86A 3so9B-1fu1A:
undetectable		 3so9B-1fu1A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		4 / 7 LEU A 126
ALA A  42
GLY A  45
ILE A  34
 None
 0.68A 3spkB-1fu1A:
0.0		 3spkB-1fu1A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		5 / 9 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.77A 3u7sA-1fu1A:
undetectable		 3u7sA-1fu1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		5 / 12 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.82A 3ucbA-1fu1A:
undetectable		 3ucbA-1fu1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		5 / 12 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.86A 3ucbB-1fu1A:
undetectable		 3ucbB-1fu1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		3 / 3 ASP A 132
ARG A   3
LYS A 129
 CAS  A 128 ( 3.1A)
ACY  A 504 (-2.8A)
CAS  A 130 ( 1.3A)
 1.18A 3wipG-1fu1A:
0.0		 3wipG-1fu1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		4 / 7 PHE A  95
PHE A 111
ALA A  73
LEU A  28
 None
 0.63A 4ejgC-1fu1A:
undetectable		 4ejgC-1fu1A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		4 / 5 TYR A  94
LEU A  10
GLU A  98
VAL A  83
 None
 1.31A 4nkvA-1fu1A:
0.0		 4nkvA-1fu1A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		3 / 3 ASN A 118
ALA A 120
ARG A 124
 None
 0.35A 5cvtB-1fu1A:
undetectable		 5cvtB-1fu1A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		4 / 7 SER A  53
ALA A  56
GLY A  64
VAL A  67
 None
 0.83A 5fpdB-1fu1A:
undetectable		 5fpdB-1fu1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		5 / 12 LEU A  28
ILE A  34
LEU A 108
ALA A  73
TYR A  66
 None
None
ACY  A 501 ( 4.9A)
None
None
 1.08A 6djzA-1fu1A:
undetectable		 6djzA-1fu1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		5 / 12 LEU A  28
ILE A  34
THR A  37
LEU A 108
TYR A  66
 None
None
None
ACY  A 501 ( 4.9A)
None
 1.24A 6djzA-1fu1A:
undetectable		 6djzA-1fu1A:
20.75