SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fuk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1fuk EUKARYOTIC
INITIATION FACTOR 4A
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 357
GLY A 350
GLY A 351
LEU A 330
ASN A 394
 None
 1.20A 1xdsA-1fukA:
undetectable		 1xdsA-1fukA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1fuk EUKARYOTIC
INITIATION FACTOR 4A
(Saccharomyces
cerevisiae) 		6 / 12 ASN A 333
LEU A 319
ILE A 289
MET A 302
LEU A 313
SER A 315
 None
 1.44A 3nk7B-1fukA:
undetectable		 3nk7B-1fukA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1fuk EUKARYOTIC
INITIATION FACTOR 4A
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 253
VAL A 358
VAL A 259
PHE A 236
LEU A 385
 None
 1.42A 5cymA-1fukA:
undetectable		 5cymA-1fukA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1fuk EUKARYOTIC
INITIATION FACTOR 4A
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 253
VAL A 358
VAL A 259
PHE A 236
LEU A 385
 None
 1.42A 5cyqA-1fukA:
undetectable		 5cyqA-1fukA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1fuk EUKARYOTIC
INITIATION FACTOR 4A
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 382
ILE A 264
PHE A 362
PHE A 236
LEU A 392
 None
 1.08A 5fa8A-1fukA:
3.4		 5fa8A-1fukA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 1fuk EUKARYOTIC
INITIATION FACTOR 4A
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 253
VAL A 358
VAL A 259
PHE A 236
LEU A 385
 None
 1.42A 6eliA-1fukA:
undetectable		 6eliA-1fukA:
19.25