SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fvf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 1fvf SEC1
(Doryteuthis
pealeii) 		3 / 3 ASP A 231
LEU A 230
HIS A 462
 None
 0.70A 1qknA-1fvfA:
0.0		 1qknA-1fvfA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 1fvf SEC1
(Doryteuthis
pealeii) 		4 / 7 GLY A 445
ARG A 189
ILE A 457
PRO A 458
 None
 1.05A 1rxcF-1fvfA:
undetectable		 1rxcF-1fvfA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 1fvf SEC1
(Doryteuthis
pealeii) 		4 / 7 GLY A 445
ARG A 189
ILE A 457
PRO A 458
 None
 1.05A 1rxcL-1fvfA:
undetectable		 1rxcL-1fvfA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1fvf SEC1
(Doryteuthis
pealeii) 		4 / 8 TYR A 400
ILE A 430
ARG A 586
ILE A 437
 None
 0.82A 2bu8A-1fvfA:
0.1		 2bu8A-1fvfA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 1fvf SEC1
(Doryteuthis
pealeii) 		4 / 6 TYR A 400
ILE A 430
ARG A 586
ILE A 437
 None
 0.87A 2q8hA-1fvfA:
0.0		 2q8hA-1fvfA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1fvf SEC1
(Doryteuthis
pealeii) 		4 / 7 ASP A  87
LEU A  84
ILE A  29
ARG A  62
 None
 1.00A 2qqdA-1fvfA:
0.0
2qqdE-1fvfA:
0.0		 2qqdA-1fvfA:
7.04
2qqdE-1fvfA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 12 LEU A 227
SER A 550
TYR A 549
SER A 548
TYR A 556
 None
 1.10A 2vdmA-1fvfA:
0.0
2vdmB-1fvfA:
2.4		 2vdmA-1fvfA:
21.59
2vdmB-1fvfA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 12 HIS A 500
ASP A 497
GLU A 489
TYR A 483
ILE A 487
 None
 1.39A 3b7pA-1fvfA:
3.5		 3b7pA-1fvfA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 12 HIS A 500
ASP A 497
GLU A 489
TYR A 483
ILE A 487
 None
 1.37A 3b7pB-1fvfA:
undetectable		 3b7pB-1fvfA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1fvf SEC1
(Doryteuthis
pealeii) 		3 / 3 LYS A 435
LYS A 423
VAL A 425
 None
 0.92A 3brfA-1fvfA:
undetectable		 3brfA-1fvfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1fvf SEC1
(Doryteuthis
pealeii) 		4 / 6 LEU A 346
SER A 343
TYR A 342
LEU A 339
 None
 1.05A 3f33A-1fvfA:
2.4		 3f33A-1fvfA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 11 ARG A 586
GLN A 442
VAL A 446
PRO A 236
TYR A 400
 None
 1.43A 3ganA-1fvfA:
0.0		 3ganA-1fvfA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1fvf SEC1
(Doryteuthis
pealeii) 		3 / 3 CYH A 169
PRO A 164
ASP A 148
 None
 0.80A 3hlwB-1fvfA:
0.0		 3hlwB-1fvfA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 12 PRO A 502
TYR A 153
VAL A 544
ALA A 199
SER A 197
 None
 1.16A 4a84A-1fvfA:
0.3		 4a84A-1fvfA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 1fvf SEC1
(Doryteuthis
pealeii) 		4 / 7 ASN A 195
PHE A 198
ALA A 199
LEU A 228
 None
 0.78A 4ejgA-1fvfA:
0.0		 4ejgA-1fvfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 1fvf SEC1
(Doryteuthis
pealeii) 		4 / 8 ASN A 195
PHE A 198
ALA A 199
LEU A 228
 None
 0.75A 4ejgB-1fvfA:
undetectable		 4ejgB-1fvfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1fvf SEC1
(Doryteuthis
pealeii) 		4 / 6 GLU A 138
GLN A 247
THR A 573
HIS A 574
 None
 1.34A 4pfjB-1fvfA:
3.6		 4pfjB-1fvfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 1fvf SEC1
(Doryteuthis
pealeii) 		3 / 3 CYH A 169
PRO A 164
ASP A 148
 None
 0.86A 4pm5A-1fvfA:
0.0		 4pm5A-1fvfA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 12 HIS A 359
GLN A 355
HIS A 242
ASP A 401
SER A 398
 None
 1.20A 4r88A-1fvfA:
undetectable		 4r88A-1fvfA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1fvf SEC1
(Doryteuthis
pealeii) 		4 / 8 ILE A 430
LEU A 240
LEU A 581
ILE A 437
 None
 0.98A 4xtaB-1fvfA:
0.0		 4xtaB-1fvfA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 1fvf SEC1
(Doryteuthis
pealeii) 		4 / 6 ALA A 248
SER A 550
GLN A 368
SER A 478
 None
 1.22A 5c6pA-1fvfA:
0.0		 5c6pA-1fvfA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 12 ILE A 411
GLY A 415
ILE A 416
ILE A 437
MET A 441
 None
 0.94A 5e72A-1fvfA:
3.1		 5e72A-1fvfA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 10 ASP A 231
ILE A 487
TYR A 501
LEU A 228
ILE A 457
 None
 1.02A 5hw8C-1fvfA:
undetectable
5hw8H-1fvfA:
undetectable		 5hw8C-1fvfA:
13.10
5hw8H-1fvfA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 12 ILE A 588
ILE A 430
ILE A 448
LEU A 421
VAL A 425
 None
 0.98A 5mueA-1fvfA:
0.0		 5mueA-1fvfA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1fvf SEC1
(Doryteuthis
pealeii) 		4 / 5 TYR A 556
SER A 554
GLN A 247
THR A 245
 None
 1.33A 5n0wB-1fvfA:
0.0		 5n0wB-1fvfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 12 PHE A 198
ALA A 199
ALA A   2
ALA A   6
THR A 179
 None
 1.20A 5tl8A-1fvfA:
0.0		 5tl8A-1fvfA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 12 VAL A 446
PRO A 236
GLU A 551
THR A 573
HIS A 574
 None
 1.23A 5xioB-1fvfA:
undetectable		 5xioB-1fvfA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1fvf SEC1
(Doryteuthis
pealeii) 		3 / 3 GLY A 545
ASP A 584
ILE A 588
 None
 0.60A 6dgxB-1fvfA:
undetectable		 6dgxB-1fvfA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 11 VAL A 186
ILE A 173
ALA A 170
ALA A 208
LEU A 206
 None
 1.22A 6h1lB-1fvfA:
0.0		 6h1lB-1fvfA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1fvf SEC1
(Doryteuthis
pealeii) 		5 / 12 LEU A 570
ILE A 541
LEU A 227
ILE A 229
ALA A 199
 None
 1.41A 6qyaB-1fvfA:
0.0		 6qyaB-1fvfA:
19.24