SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fw1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 1fw1 GLUTATHIONE
TRANSFERASE ZETA
(Homo
sapiens) 		5 / 11 ALA A 150
THR A 149
ILE A 102
LEU A  73
LEU A 166
 None
 1.09A 1b02A-1fw1A:
undetectable		 1b02A-1fw1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 1fw1 GLUTATHIONE
TRANSFERASE ZETA
(Homo
sapiens) 		5 / 12 THR A 160
ALA A 162
ASP A 163
LEU A 166
MET A 101
 None
 1.23A 1errA-1fw1A:
undetectable		 1errA-1fw1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1fw1 GLUTATHIONE
TRANSFERASE ZETA
(Homo
sapiens) 		3 / 3 LYS A 177
ILE A 135
THR A 181
 None
 0.85A 1rx3A-1fw1A:
undetectable		 1rx3A-1fw1A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fw1 GLUTATHIONE
TRANSFERASE ZETA
(Homo
sapiens) 		5 / 12 ILE A 106
ILE A 135
PHE A 139
LEU A 142
ALA A 141
 None
 0.95A 2aclG-1fw1A:
undetectable		 2aclG-1fw1A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1fw1 GLUTATHIONE
TRANSFERASE ZETA
(Homo
sapiens) 		4 / 7 PHE A 139
LEU A 142
LEU A 146
GLU A 174
 None
 1.04A 2jn3A-1fw1A:
undetectable		 2jn3A-1fw1A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1fw1 GLUTATHIONE
TRANSFERASE ZETA
(Homo
sapiens) 		3 / 3 LYS A 177
ILE A 135
THR A 181
 None
 0.84A 4gh8A-1fw1A:
undetectable		 4gh8A-1fw1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 1fw1 GLUTATHIONE
TRANSFERASE ZETA
(Homo
sapiens) 		4 / 6 ALA A  23
LYS A  27
LEU A 164
MET A 161
 None
 1.18A 4xoyA-1fw1A:
undetectable		 4xoyA-1fw1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 1fw1 GLUTATHIONE
TRANSFERASE ZETA
(Homo
sapiens) 		4 / 6 ALA A  23
LYS A  27
LEU A 164
MET A 161
 None
 1.18A 4xp3A-1fw1A:
undetectable		 4xp3A-1fw1A:
20.11