SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fw3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A
(Escherichia
coli) 		4 / 8 GLU A 137
GLY A 139
ASP A  36
THR A  93
 None
 0.77A 1m4iA-1fw3A:
0.0		 1m4iA-1fw3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A
(Escherichia
coli) 		3 / 3 ILE A  19
ILE A  18
THR A 124
 None
 0.47A 1rg7A-1fw3A:
undetectable		 1rg7A-1fw3A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A
(Escherichia
coli) 		4 / 8 SER A 248
ASP A 251
ASN A 113
GLN A  94
 None
None
S1H  A 144 ( 4.2A)
None
 1.11A 2cmlC-1fw3A:
undetectable		 2cmlC-1fw3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A
(Escherichia
coli) 		3 / 3 LEU A  48
ASN A  49
ARG A 110
 None
 0.79A 2qhfA-1fw3A:
0.0		 2qhfA-1fw3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A
(Escherichia
coli) 		4 / 8 ARG A 157
TYR A  35
ARG A 161
THR A  93
 None
 1.36A 2vxaF-1fw3A:
0.0
2vxaG-1fw3A:
0.0
2vxaI-1fw3A:
0.0		 2vxaF-1fw3A:
14.06
2vxaG-1fw3A:
14.06
2vxaI-1fw3A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A
(Escherichia
coli) 		4 / 6 ASP A 251
ASP A 149
ASN A 145
GLU A 111
 None
None
S1H  A 144 ( 4.9A)
None
 1.20A 3vywA-1fw3A:
undetectable		 3vywA-1fw3A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A
(Escherichia
coli) 		4 / 5 ASP A 251
ASP A 149
ASN A 145
GLU A 111
 None
None
S1H  A 144 ( 4.9A)
None
 1.11A 3vywD-1fw3A:
undetectable		 3vywD-1fw3A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A
(Escherichia
coli) 		4 / 7 THR A 112
TYR A  92
LEU A  71
PHE A 109
 None
S1H  A 144 ( 3.8A)
None
None
 1.07A 4awuA-1fw3A:
undetectable		 4awuA-1fw3A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A
(Escherichia
coli) 		4 / 5 ASP A  47
THR A  45
GLN A 256
ARG A 258
 None
 1.49A 5k9dA-1fw3A:
0.0		 5k9dA-1fw3A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A
(Escherichia
coli) 		4 / 4 ARG A 110
GLU A  66
GLU A 247
ARG A 258
 None
 1.31A 6fk2A-1fw3A:
undetectable		 6fk2A-1fw3A:
17.92