SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fw8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 300
GLY A 322
GLY A 321
PHE A  92
PHE A 123
 None
 0.85A 1dx6A-1fw8A:
undetectable		 1dx6A-1fw8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A 278
LEU A 282
VAL A 285
 None
 0.21A 1mz9E-1fw8A:
undetectable		 1mz9E-1fw8A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 300
GLY A 322
GLY A 321
PHE A  92
PHE A 123
 None
 0.87A 1qtiA-1fw8A:
undetectable		 1qtiA-1fw8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 149
ALA A 136
ILE A 160
GLY A 139
 None
 0.81A 1sv9A-1fw8A:
undetectable		 1sv9A-1fw8A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 300
GLY A 322
GLY A 321
PHE A  92
PHE A 123
 None
 0.87A 1w6rA-1fw8A:
undetectable		 1w6rA-1fw8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 127
PRO A 130
THR A 294
ILE A 296
PHE A 134
 None
 1.45A 1xoqA-1fw8A:
undetectable		 1xoqA-1fw8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 127
PRO A 130
THR A 294
ILE A 296
PHE A 134
 None
 1.49A 1xoqB-1fw8A:
undetectable		 1xoqB-1fw8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 298
SER A 319
LEU A 329
HIS A 317
 None
 0.97A 1yajF-1fw8A:
0.9		 1yajF-1fw8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 299
SER A 319
ILE A 296
HIS A 317
 None
 1.29A 1yajJ-1fw8A:
0.7		 1yajJ-1fw8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 257
PHE A 134
ALA A 136
LEU A 138
LEU A 153
 None
 1.05A 2bxqA-1fw8A:
undetectable		 2bxqA-1fw8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 5 PRO A 234
ILE A 233
GLY A 232
LYS A 225
 None
 1.07A 2qeuA-1fw8A:
0.0
2qeuC-1fw8A:
0.0		 2qeuA-1fw8A:
17.51
2qeuC-1fw8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 304
GLY A 322
GLY A 298
ASP A 367
ASN A 369
 None
None
None
GOL  A 973 (-3.6A)
None
 0.99A 2zw9B-1fw8A:
undetectable		 2zw9B-1fw8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 249
GLY A 163
ILE A 137
VAL A 207
GLY A 264
 None
 0.92A 3bwcB-1fw8A:
3.2		 3bwcB-1fw8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 309
GLY A 140
LEU A 138
ASN A 263
VAL A 305
 None
 0.99A 3dmhA-1fw8A:
2.8		 3dmhA-1fw8A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 337
LEU A 329
LEU A 346
GLY A 323
ALA A 324
 None
 1.04A 3n8wA-1fw8A:
0.0		 3n8wA-1fw8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 298
GLY A 299
SER A 319
PHE A  92
 None
 0.71A 3o9mA-1fw8A:
undetectable		 3o9mA-1fw8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 8 ILE A 161
LEU A 135
GLU A 284
ALA A 252
ALA A 255
 None
 1.19A 3r9tA-1fw8A:
undetectable		 3r9tA-1fw8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 7 ILE A 161
LEU A 135
GLU A 284
ALA A 252
ALA A 255
 None
 1.21A 3r9tB-1fw8A:
undetectable		 3r9tB-1fw8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 337
LEU A 329
LEU A 346
GLY A 322
ALA A 324
 None
 1.12A 3rr3C-1fw8A:
0.0		 3rr3C-1fw8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 337
LEU A 329
LEU A 346
GLY A 323
ALA A 324
 None
 1.04A 3rr3C-1fw8A:
0.0		 3rr3C-1fw8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 337
LEU A 329
LEU A 346
GLY A 322
ALA A 324
 None
 1.13A 3rr3D-1fw8A:
0.0		 3rr3D-1fw8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 337
LEU A 329
LEU A 346
GLY A 323
ALA A 324
 None
 1.05A 3rr3D-1fw8A:
0.0		 3rr3D-1fw8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  88
LEU A   5
VAL A  31
PHE A 363
VAL A  27
 None
 1.07A 3w68B-1fw8A:
0.0		 3w68B-1fw8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 407
GLU A  47
SER A 405
 None
 0.70A 4ccqA-1fw8A:
0.3		 4ccqA-1fw8A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 300
GLY A 322
GLY A 321
PHE A  92
PHE A 123
 None
 0.84A 4ey6A-1fw8A:
undetectable		 4ey6A-1fw8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 300
GLY A 322
GLY A 321
PHE A 123
PHE A  92
 None
 0.94A 4ey6A-1fw8A:
undetectable		 4ey6A-1fw8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 300
GLY A 322
GLY A 321
PHE A  92
PHE A 123
 None
 0.85A 4ey6B-1fw8A:
undetectable		 4ey6B-1fw8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 8 ARG A 110
ASN A  89
ALA A  91
ASP A 367
PRO A 335
 None
None
None
GOL  A 973 (-3.6A)
None
 1.47A 4eyrB-1fw8A:
undetectable		 4eyrB-1fw8A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 250
GLY A 165
GLY A 164
GLY A 163
ALA A 141
 None
 1.01A 4l8fB-1fw8A:
2.5		 4l8fB-1fw8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 250
GLY A 165
GLY A 164
GLY A 163
ALA A 141
 None
 1.01A 4l8fD-1fw8A:
2.5		 4l8fD-1fw8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 241
GLY A 277
ASP A 211
THR A 224
ILE A 213
 None
 1.02A 4njvB-1fw8A:
undetectable		 4njvB-1fw8A:
13.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		9 / 12 GLY A 140
ALA A 141
GLY A 164
GLY A 165
PHE A 168
PHE A 218
LEU A 240
GLY A 267
VAL A 268
 None
 0.55A 4o33A-1fw8A:
18.8		 4o33A-1fw8A:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 140
GLY A 164
PHE A 168
PHE A 218
LEU A 240
VAL A 268
 None
 1.35A 4o33A-1fw8A:
18.8		 4o33A-1fw8A:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		9 / 12 GLY A 140
ALA A 141
GLY A 164
GLY A 165
PHE A 168
PHE A 218
LEU A 240
GLY A 267
VAL A 268
 None
 0.49A 4o3fA-1fw8A:
30.7		 4o3fA-1fw8A:
52.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  52
GLU A 413
ASP A  25
GLU A  47
GLY A 412
 None
 1.37A 4pgfB-1fw8A:
4.2		 4pgfB-1fw8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 8 THR A 278
GLU A 272
PHE A 274
GLY A 267
 None
 0.84A 4r3aA-1fw8A:
undetectable		 4r3aA-1fw8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 114
ASP A  90
ILE A  88
ASN A  89
TYR A 392
 None
 0.99A 4rtrA-1fw8A:
undetectable		 4rtrA-1fw8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 114
ASP A  90
ILE A  88
ASN A  89
TYR A 392
 None
 0.95A 4rtsA-1fw8A:
undetectable		 4rtsA-1fw8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_C_QI9C602_0
(CYTOCHROME P450 2D6)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 368
ASP A 367
VAL A  20
VAL A   8
PHE A  22
 None
GOL  A 973 (-3.6A)
None
None
None
 1.46A 4wnvC-1fw8A:
0.0		 4wnvC-1fw8A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 357
ASP A 359
ILE A 390
 None
 0.70A 4xi3D-1fw8A:
undetectable		 4xi3D-1fw8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 306
TYR A 309
PRO A 266
 None
 0.49A 4zdyA-1fw8A:
0.0		 4zdyA-1fw8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 9 ARG A  97
ALA A  98
LEU A 334
GLY A 336
GLU A 327
 None
 0.96A 5dqfA-1fw8A:
undetectable		 5dqfA-1fw8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 116
GLY A  93
ASN A  89
TYR A  87
PHE A 363
 None
GOL  A 973 ( 4.7A)
None
None
None
 1.29A 5kklB-1fw8A:
undetectable		 5kklB-1fw8A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 9 PHE A 363
VAL A 393
THR A 389
ILE A  88
 None
 1.00A 5lg3I-1fw8A:
undetectable		 5lg3I-1fw8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 301
VAL A 157
PHE A 250
ALA A 167
GLY A 165
 None
 1.09A 5uxdB-1fw8A:
undetectable		 5uxdB-1fw8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 5 PRO A 193
VAL A 173
GLY A 163
VAL A 143
 None
 0.88A 6ak3B-1fw8A:
0.0		 6ak3B-1fw8A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 5 PRO A 193
VAL A 173
GLY A 164
VAL A 143
 None
 1.09A 6ak3B-1fw8A:
0.0		 6ak3B-1fw8A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 4 PHE A  76
ASP A  72
LEU A  80
LYS A  75
 None
 1.25A 6awvA-1fw8A:
0.0		 6awvA-1fw8A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 398
LEU A 394
VAL A  86
VAL A 362
LEU A 350
 None
 1.23A 6b52A-1fw8A:
undetectable		 6b52A-1fw8A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 122
VAL A 261
VAL A 295
THR A 294
 None
 1.43A 6f32B-1fw8A:
undetectable		 6f32B-1fw8A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 367
ARG A  50
GLU A  55
VAL A 103
 GOL  A 973 (-3.6A)
None
None
None
 0.94A 6fbvD-1fw8A:
0.0		 6fbvD-1fw8A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 247
PHE A 250
GLY A 277
 None
 0.70A 6fgdA-1fw8A:
2.6		 6fgdA-1fw8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 151
ILE A 191
PRO A 193
LEU A 195
 None
 1.26A 6mkeB-1fw8A:
0.0		 6mkeB-1fw8A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 151
ILE A 191
PRO A 193
LEU A 195
 None
 1.32A 6mkeA-1fw8A:
0.0		 6mkeA-1fw8A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 164
GLY A 140
VAL A 143
ASP A 241
PHE A 170
 None
 1.04A 6nj9K-1fw8A:
3.1		 6nj9K-1fw8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1fw8 PHOSPHOGLYCERATE
KINASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 372
PRO A   7
TYR A  51
GLU A  47
 None
 0.94A 6pahA-1fw8A:
undetectable		 6pahA-1fw8A:
22.85