SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fwx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 5 HIS A 270
HIS A 437
HIS A  79
HIS A 128
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.2A)
 0.88A 1e9yB-1fwxA:
undetectable		 1e9yB-1fwxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 8 SER A  29
HIS A 437
SER A  25
ARG A  33
 None
CUZ  A4801 (-3.0A)
None
None
 0.99A 1eqbA-1fwxA:
undetectable
1eqbB-1fwxA:
undetectable		 1eqbA-1fwxA:
21.68
1eqbB-1fwxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 8 SER A  29
HIS A 437
SER A  25
ARG A  33
 None
CUZ  A4801 (-3.0A)
None
None
 0.99A 1eqbC-1fwxA:
undetectable
1eqbD-1fwxA:
undetectable		 1eqbC-1fwxA:
21.68
1eqbD-1fwxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 8 SER A  29
HIS A 437
SER A  25
ARG A  33
 None
CUZ  A4801 (-3.0A)
None
None
 0.98A 1eqbC-1fwxA:
undetectable
1eqbD-1fwxA:
undetectable		 1eqbC-1fwxA:
21.68
1eqbD-1fwxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 8 PHE A 549
TYR A 533
VAL A 487
VAL A 489
 None
 0.91A 1iwiA-1fwxA:
0.0		 1iwiA-1fwxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 GLU A 316
ALA A 355
GLY A 358
TYR A 356
ARG A 310
 None
 1.43A 1l5rA-1fwxA:
undetectable		 1l5rA-1fwxA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 8 SER A 138
ASN A 139
GLU A  87
GLY A  88
 None
 0.66A 1meiA-1fwxA:
undetectable		 1meiA-1fwxA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 8 PHE A 549
TYR A 533
VAL A 487
VAL A 489
 None
 0.92A 1t86A-1fwxA:
0.0		 1t86A-1fwxA:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 HIS A 526
CYH A 561
CYH A 565
MET A 572
 CUA  A4701 (-3.1A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.4A)
 0.10A 2iwkA-1fwxA:
70.4		 2iwkA-1fwxA:
85.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-3.0A)
 0.09A 2iwkA-1fwxA:
70.4		 2iwkA-1fwxA:
85.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 HIS A 526
CYH A 561
CYH A 565
MET A 572
 CUA  A4701 (-3.1A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.4A)
 0.11A 2iwkB-1fwxA:
70.6		 2iwkB-1fwxA:
85.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-3.0A)
 0.11A 2iwkB-1fwxA:
70.6		 2iwkB-1fwxA:
85.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 7 PHE A 549
TYR A 533
VAL A 487
VAL A 489
 None
 0.90A 2qbnA-1fwxA:
0.0		 2qbnA-1fwxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 TRP A  57
GLN A  59
TRP A 461
 None
 1.29A 2vqyA-1fwxA:
0.8		 2vqyA-1fwxA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 GLU A 538
GLN A  59
ARG A  51
 None
 0.96A 2w3bB-1fwxA:
undetectable		 2w3bB-1fwxA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 HIS A 128
HIS A  80
HIS A 325
ASN A 273
VAL A 283
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 ( 3.3A)
CL  A4901 (-3.5A)
None
 1.19A 2zweA-1fwxA:
0.0
2zweB-1fwxA:
0.6		 2zweA-1fwxA:
18.57
2zweB-1fwxA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 HIS A 128
HIS A  80
HIS A 325
ASN A 273
VAL A 283
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 ( 3.3A)
CL  A4901 (-3.5A)
None
 1.20A 2zwfA-1fwxA:
undetectable
2zwfB-1fwxA:
0.7		 2zwfA-1fwxA:
18.57
2zwfB-1fwxA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 HIS A 128
HIS A  80
HIS A 325
ASN A 273
VAL A 283
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 ( 3.3A)
CL  A4901 (-3.5A)
None
 1.22A 2zwgA-1fwxA:
undetectable
2zwgB-1fwxA:
0.7		 2zwgA-1fwxA:
18.57
2zwgB-1fwxA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 HIS A 526
CYH A 561
CYH A 565
MET A 572
 CUA  A4701 (-3.1A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.4A)
 0.45A 3dtuB-1fwxA:
9.7		 3dtuB-1fwxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-3.0A)
 0.20A 3dtuB-1fwxA:
9.7		 3dtuB-1fwxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-3.0A)
 0.19A 3dtuD-1fwxA:
9.2		 3dtuD-1fwxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 HIS A 526
CYH A 561
CYH A 565
MET A 572
 CUA  A4701 (-3.1A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.4A)
 0.46A 3dtuD-1fwxA:
9.2		 3dtuD-1fwxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 ARG A 109
ASP A 455
ASP A 458
PRO A 459
 None
 0.90A 3fgrB-1fwxA:
undetectable		 3fgrB-1fwxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 5 ASN A 268
ASN A 189
HIS A 325
ALA A 284
 CA  A4903 (-3.0A)
CL  A4901 (-3.8A)
CUZ  A4801 ( 3.3A)
None
 1.44A 3frqA-1fwxA:
0.0		 3frqA-1fwxA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 7 ASN A 268
ASN A 189
HIS A 325
ALA A 284
 CA  A4903 (-3.0A)
CL  A4901 (-3.8A)
CUZ  A4801 ( 3.3A)
None
 1.44A 3frqB-1fwxA:
undetectable		 3frqB-1fwxA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 12 ASP A 523
ASP A 522
VAL A 453
GLY A 540
ILE A 539
 None
 0.96A 3s56A-1fwxA:
undetectable		 3s56A-1fwxA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 ALA A 327
GLY A 271
ALA A 284
PRO A 374
LEU A 377
 None
CL  A4901 ( 3.7A)
None
None
None
 0.93A 3sm2B-1fwxA:
undetectable		 3sm2B-1fwxA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 8 HIS A  80
HIS A 128
HIS A  79
HIS A 270
 CUZ  A4801 (-3.3A)
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.2A)
 1.05A 3w6hA-1fwxA:
undetectable		 3w6hA-1fwxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 5 HIS A 270
LEU A  78
LEU A 130
ASP A  99
 CUZ  A4801 (-3.2A)
None
None
None
 1.23A 4aqlA-1fwxA:
undetectable		 4aqlA-1fwxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 7 PHE A 549
TYR A 533
VAL A 487
VAL A 489
 None
 0.92A 4cp4A-1fwxA:
0.0		 4cp4A-1fwxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 9 SER A 492
ASN A 517
ILE A 539
GLY A 527
CYH A 561
 None
None
None
None
CUA  A4701 (-2.2A)
 1.43A 4fxsA-1fwxA:
undetectable		 4fxsA-1fwxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 5 HIS A 270
HIS A 437
HIS A  79
HIS A 128
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.2A)
 0.75A 4h9mA-1fwxA:
undetectable		 4h9mA-1fwxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB601_1
(SERUM ALBUMIN)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 10 ASN A 273
CYH A 282
ARG A 131
THR A 336
LEU A 377
 CL  A4901 (-3.5A)
None
CL  A4901 (-3.1A)
None
None
 1.42A 4or0B-1fwxA:
undetectable		 4or0B-1fwxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 7 HIS A 437
HIS A  80
ASN A  98
HIS A 128
 CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.3A)
None
CUZ  A4801 (-3.2A)
 0.87A 4p6sA-1fwxA:
undetectable		 4p6sA-1fwxA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 7 HIS A 437
HIS A  80
ASN A  98
HIS A 128
 CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.3A)
None
CUZ  A4801 (-3.2A)
 0.94A 4p6sB-1fwxA:
undetectable		 4p6sB-1fwxA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 7 HIS A 437
HIS A  80
ASN A  98
HIS A 128
 CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.3A)
None
CUZ  A4801 (-3.2A)
 0.88A 5i3aA-1fwxA:
undetectable		 5i3aA-1fwxA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 7 HIS A 437
HIS A  80
ASN A  98
HIS A 128
 CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.3A)
None
CUZ  A4801 (-3.2A)
 0.90A 5i3aB-1fwxA:
undetectable		 5i3aB-1fwxA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 7 HIS A 437
HIS A  80
ASN A  98
HIS A 128
 CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.3A)
None
CUZ  A4801 (-3.2A)
 0.87A 5i3bA-1fwxA:
undetectable		 5i3bA-1fwxA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 7 GLY A 271
GLY A 285
SER A 288
LEU A 319
 CL  A4901 ( 3.7A)
None
None
None
 0.68A 5izfA-1fwxA:
undetectable		 5izfA-1fwxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 7 ASP A 523
ASP A 522
GLY A 540
ILE A 539
 None
 0.69A 5kqyB-1fwxA:
undetectable		 5kqyB-1fwxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 8 VAL A 177
ILE A 121
ALA A 124
VAL A 250
VAL A 246
 None
 1.26A 5l94A-1fwxA:
undetectable		 5l94A-1fwxA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 7 HIS A 437
HIS A  80
ASN A  98
HIS A 128
 CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.3A)
None
CUZ  A4801 (-3.2A)
 0.94A 5m8rA-1fwxA:
0.0		 5m8rA-1fwxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 8 HIS A 437
HIS A  80
ASN A  98
HIS A 128
 CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.3A)
None
CUZ  A4801 (-3.2A)
 0.95A 5m8rB-1fwxA:
0.0		 5m8rB-1fwxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 8 HIS A 437
HIS A  80
ASN A  98
HIS A 128
 CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.3A)
None
CUZ  A4801 (-3.2A)
 0.94A 5m8rD-1fwxA:
undetectable		 5m8rD-1fwxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 HIS A 128
ASP A 188
HIS A 270
 CUZ  A4801 (-3.2A)
None
CUZ  A4801 (-3.2A)
 0.71A 5oexA-1fwxA:
26.8		 5oexA-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 HIS A 270
ASP A 188
HIS A 128
 CUZ  A4801 (-3.2A)
None
CUZ  A4801 (-3.2A)
 0.72A 5oexA-1fwxA:
26.8		 5oexA-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 LYS A 100
HIS A 128
HIS A  79
 None
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.2A)
 0.84A 5oexA-1fwxA:
26.8		 5oexA-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA603_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 LYS A 100
HIS A 128
HIS A  80
HIS A  79
 None
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 (-3.2A)
 1.17A 5oexA-1fwxA:
26.8		 5oexA-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 HIS A 376
HIS A 437
HIS A  79
 CUZ  A4801 (-3.3A)
CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.2A)
 0.50A 5oexA-1fwxA:
26.8		 5oexA-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 HIS A 128
ASP A 188
HIS A 270
 CUZ  A4801 (-3.2A)
None
CUZ  A4801 (-3.2A)
 0.63A 5oexB-1fwxA:
8.0		 5oexB-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 HIS A 270
ASP A 188
HIS A 128
 CUZ  A4801 (-3.2A)
None
CUZ  A4801 (-3.2A)
 0.77A 5oexB-1fwxA:
8.0		 5oexB-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 LYS A 100
HIS A 128
HIS A  79
 None
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.2A)
 0.95A 5oexB-1fwxA:
8.0		 5oexB-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB603_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 LYS A 100
HIS A 128
HIS A  80
HIS A  79
 None
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 (-3.2A)
 1.20A 5oexB-1fwxA:
8.0		 5oexB-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 HIS A 128
ASP A 188
HIS A 270
 CUZ  A4801 (-3.2A)
None
CUZ  A4801 (-3.2A)
 0.59A 5oexC-1fwxA:
11.3		 5oexC-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 HIS A 270
ASP A 188
HIS A 128
 CUZ  A4801 (-3.2A)
None
CUZ  A4801 (-3.2A)
 0.73A 5oexC-1fwxA:
11.3		 5oexC-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC602_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 LYS A 100
HIS A 128
HIS A  80
HIS A  79
 None
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 (-3.2A)
 1.20A 5oexC-1fwxA:
11.3		 5oexC-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 LYS A 100
HIS A 128
HIS A  79
 None
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.2A)
 0.91A 5oexC-1fwxA:
11.3		 5oexC-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 HIS A 128
ASP A 188
HIS A 270
 CUZ  A4801 (-3.2A)
None
CUZ  A4801 (-3.2A)
 0.59A 5oexD-1fwxA:
19.3		 5oexD-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 HIS A 270
ASP A 188
HIS A 128
 CUZ  A4801 (-3.2A)
None
CUZ  A4801 (-3.2A)
 0.74A 5oexD-1fwxA:
19.3		 5oexD-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 LYS A 100
HIS A 128
HIS A  79
 None
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.2A)
 0.84A 5oexD-1fwxA:
19.3		 5oexD-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD604_0
(THIOCYANATE
DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 LYS A 100
HIS A 128
HIS A  80
HIS A  79
 None
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 (-3.2A)
 1.15A 5oexD-1fwxA:
19.3		 5oexD-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 HIS A 128
HIS A  80
HIS A 325
ASN A 273
VAL A 283
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 ( 3.3A)
CL  A4901 (-3.5A)
None
 1.18A 5z0fA-1fwxA:
undetectable
5z0fB-1fwxA:
0.8		 5z0fA-1fwxA:
9.59
5z0fB-1fwxA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 HIS A 128
HIS A  80
HIS A 325
ASN A 273
VAL A 283
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 ( 3.3A)
CL  A4901 (-3.5A)
None
 1.19A 5z0gA-1fwxA:
0.0
5z0gB-1fwxA:
0.8		 5z0gA-1fwxA:
9.59
5z0gB-1fwxA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 HIS A 128
HIS A  80
HIS A 325
ASN A 273
VAL A 283
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 ( 3.3A)
CL  A4901 (-3.5A)
None
 1.21A 5z0hA-1fwxA:
0.0
5z0hB-1fwxA:
1.1		 5z0hA-1fwxA:
9.59
5z0hB-1fwxA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 HIS A 128
HIS A  80
HIS A 325
ASN A 273
VAL A 283
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 ( 3.3A)
CL  A4901 (-3.5A)
None
 1.20A 5z0iA-1fwxA:
undetectable
5z0iB-1fwxA:
0.9		 5z0iA-1fwxA:
9.59
5z0iB-1fwxA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 HIS A 128
HIS A  80
HIS A 325
ASN A 273
VAL A 283
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 ( 3.3A)
CL  A4901 (-3.5A)
None
 1.19A 5z0jA-1fwxA:
undetectable
5z0jB-1fwxA:
0.6		 5z0jA-1fwxA:
9.59
5z0jB-1fwxA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 HIS A 128
HIS A  80
HIS A 325
ASN A 273
VAL A 283
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 ( 3.3A)
CL  A4901 (-3.5A)
None
 1.19A 5z0kA-1fwxA:
undetectable
5z0kB-1fwxA:
0.6		 5z0kA-1fwxA:
9.59
5z0kB-1fwxA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 HIS A 128
HIS A  80
HIS A 325
ASN A 273
VAL A 283
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 ( 3.3A)
CL  A4901 (-3.5A)
None
 1.21A 5z0lA-1fwxA:
0.0
5z0lB-1fwxA:
0.7		 5z0lA-1fwxA:
9.59
5z0lB-1fwxA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 11 HIS A 128
HIS A  80
HIS A 325
ASN A 273
VAL A 283
 CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 ( 3.3A)
CL  A4901 (-3.5A)
None
 1.26A 5z0mA-1fwxA:
0.0
5z0mB-1fwxA:
0.6		 5z0mA-1fwxA:
9.77
5z0mB-1fwxA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 12 THR A 202
HIS A  82
ASN A 273
GLY A 271
HIS A 325
 None
None
CL  A4901 (-3.5A)
CL  A4901 ( 3.7A)
CUZ  A4801 ( 3.3A)
 1.48A 6exiA-1fwxA:
undetectable		 6exiA-1fwxA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 12 VAL A 283
VAL A 291
ASP A 193
TRP A 347
PHE A 328
 None
 1.28A 6iblA-1fwxA:
undetectable		 6iblA-1fwxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 12 VAL A 283
VAL A 291
ASP A 193
TRP A 347
PHE A 328
 None
 1.26A 6iblB-1fwxA:
undetectable		 6iblB-1fwxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 7 GLY A  76
HIS A  80
ASN A  98
GLY A 126
 None
CUZ  A4801 (-3.3A)
None
None
 0.97A 6n7fA-1fwxA:
undetectable		 6n7fA-1fwxA:
9.08