SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fx2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		5 / 10 THR A 905
LEU A 935
VAL A 932
VAL A1063
VAL A1023
 None
 1.50A 1o76A-1fx2A:
0.0		 1o76A-1fx2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		3 / 3 SER A1013
HIS A 975
ASP A 923
 None
 0.84A 2oxtA-1fx2A:
undetectable		 2oxtA-1fx2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		4 / 7 VAL A 932
TYR A 939
CYH A 941
ILE A 903
 None
 1.19A 2xz5B-1fx2A:
0.0
2xz5E-1fx2A:
undetectable		 2xz5B-1fx2A:
24.24
2xz5E-1fx2A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		5 / 8 GLY A1061
GLY A1060
GLY A1018
ILE A 907
LEU A 913
 DTT  A1124 ( 3.7A)
None
DTT  A1124 ( 4.4A)
None
None
 1.15A 3v1nA-1fx2A:
undetectable		 3v1nA-1fx2A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		4 / 8 VAL A 932
TYR A 939
CYH A 941
ILE A 903
 None
 0.93A 4afgD-1fx2A:
0.0
4afgE-1fx2A:
0.0		 4afgD-1fx2A:
21.18
4afgE-1fx2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		5 / 11 ARG A1118
LEU A1114
VAL A1098
LEU A1116
LEU A1086
 None
 1.24A 4or0B-1fx2A:
undetectable		 4or0B-1fx2A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		4 / 8 THR A 901
VAL A1083
LEU A1103
ILE A1081
 None
 0.88A 4r38D-1fx2A:
undetectable		 4r38D-1fx2A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		4 / 6 ALA A1051
THR A1054
VAL A1094
HIS A1026
 None
 1.05A 5eckA-1fx2A:
undetectable		 5eckA-1fx2A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		5 / 12 LEU A 968
THR A 905
ILE A 903
GLY A1024
ILE A1025
 None
 1.23A 5ifuA-1fx2A:
2.1		 5ifuA-1fx2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		4 / 8 ASP A1031
ILE A1032
ARG A1033
ASN A 889
 None
 1.19A 6hisA-1fx2A:
0.0
6hisB-1fx2A:
0.0		 6hisA-1fx2A:
18.26
6hisB-1fx2A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		4 / 8 ASP A1031
ILE A1032
ARG A1033
ASN A 889
 None
 1.20A 6hisB-1fx2A:
0.0
6hisC-1fx2A:
0.0		 6hisB-1fx2A:
18.26
6hisC-1fx2A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		4 / 8 ASP A1031
ILE A1032
ARG A1033
ASN A 889
 None
 1.20A 6hisC-1fx2A:
0.0
6hisD-1fx2A:
0.0		 6hisC-1fx2A:
18.26
6hisD-1fx2A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		4 / 8 ASP A1031
ILE A1032
ARG A1033
ASN A 889
 None
 1.17A 6hisD-1fx2A:
0.0
6hisE-1fx2A:
0.0		 6hisD-1fx2A:
18.26
6hisE-1fx2A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1
(Trypanosoma
brucei) 		4 / 8 ASN A 889
ASP A1031
ILE A1032
ARG A1033
 None
 1.21A 6hisA-1fx2A:
0.0
6hisE-1fx2A:
0.0		 6hisA-1fx2A:
18.26
6hisE-1fx2A:
18.26