SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fx4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 1fx4 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.3
(Trypanosoma
brucei) 		4 / 8 VAL A 950
LEU A1069
PRO A 946
SER A1062
 None
 0.99A 1jtvA-1fx4A:
undetectable		 1jtvA-1fx4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1fx4 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.3
(Trypanosoma
brucei) 		4 / 7 SER A1062
PHE A 947
GLN A1068
GLU A1064
 None
 1.26A 2c8aA-1fx4A:
undetectable		 2c8aA-1fx4A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1fx4 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.3
(Trypanosoma
brucei) 		5 / 8 GLY A1049
GLY A1048
GLY A1006
ILE A 895
LEU A 901
 None
 1.15A 3v1nA-1fx4A:
undetectable		 3v1nA-1fx4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1fx4 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.3
(Trypanosoma
brucei) 		5 / 12 GLN A 980
THR A 992
TYR A 974
SER A 897
LEU A 901
 None
 1.40A 4qztC-1fx4A:
undetectable		 4qztC-1fx4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1fx4 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.3
(Trypanosoma
brucei) 		5 / 12 ALA A1100
GLN A1050
THR A1054
VAL A1086
LEU A1104
 None
 1.21A 4qzuA-1fx4A:
0.0		 4qzuA-1fx4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1fx4 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.3
(Trypanosoma
brucei) 		4 / 7 LEU A1069
LEU A1091
ALA A 953
LEU A1061
 None
 0.65A 4z90F-1fx4A:
0.0
4z90G-1fx4A:
0.0
4z90H-1fx4A:
undetectable
4z90J-1fx4A:
undetectable		 4z90F-1fx4A:
21.04
4z90G-1fx4A:
21.04
4z90H-1fx4A:
21.04
4z90J-1fx4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 1fx4 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.3
(Trypanosoma
brucei) 		5 / 12 ALA A1057
GLY A1075
ALA A1076
LEU A1104
LEU A1079
 None
 1.05A 5xxiA-1fx4A:
0.0		 5xxiA-1fx4A:
20.13