SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fx7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 227
VAL A 163
LEU A 157
THR A 155
PRO A 158
 None
None
None
CO  A2009 ( 4.9A)
None
 1.17A 1oq5A-1fx7A:
undetectable		 1oq5A-1fx7A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		4 / 6 PRO A 218
MET A 221
ALA A 224
GLU A  21
 None
 1.34A 1qhyA-1fx7A:
undetectable		 1qhyA-1fx7A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 202
PRO A 201
THR A 216
GLY A 204
 None
None
SO4  A1017 (-3.9A)
None
 0.87A 2jklC-1fx7A:
undetectable		 2jklC-1fx7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 167
VAL A 174
LEU A 180
LEU A 170
VAL A 215
 None
None
None
None
SO4  A1017 ( 4.2A)
 1.05A 3rr3C-1fx7A:
0.0		 3rr3C-1fx7A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 197
LEU A 170
LEU A 154
TRP A  94
GLY A 188
 None
 1.05A 3rr3C-1fx7A:
0.0		 3rr3C-1fx7A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 167
VAL A 174
LEU A 180
LEU A 170
VAL A 215
 None
None
None
None
SO4  A1017 ( 4.2A)
 1.04A 3rr3D-1fx7A:
0.0		 3rr3D-1fx7A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 197
LEU A 170
LEU A 154
TRP A  94
GLY A 188
 None
 1.05A 3rr3D-1fx7A:
0.0		 3rr3D-1fx7A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 163
VAL A 197
ASN A 150
VAL A 189
 None
 1.08A 4e1gB-1fx7A:
undetectable		 4e1gB-1fx7A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		5 / 9 GLU A  83
VAL A  97
GLN A 175
LEU A 170
THR A 171
 CO  A2001 (-2.5A)
None
CO  A2001 (-2.7A)
None
None
 1.32A 5kt8B-1fx7A:
2.9		 5kt8B-1fx7A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		5 / 9 GLU A  83
VAL A  97
GLY A 129
GLN A 175
LEU A 170
 CO  A2001 (-2.5A)
None
None
CO  A2001 (-2.7A)
None
 1.25A 5kt8B-1fx7A:
2.9		 5kt8B-1fx7A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  80
ILE A 132
SER A 126
 None
 0.79A 5zw2A-1fx7A:
0.0		 5zw2A-1fx7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		5 / 9 GLU A  83
VAL A  97
GLN A 175
LEU A 170
THR A 171
 CO  A2001 (-2.5A)
None
CO  A2001 (-2.7A)
None
None
 1.39A 6cdqA-1fx7A:
0.0		 6cdqA-1fx7A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1fx7 IRON-DEPENDENT
REPRESSOR IDER
(Mycobacterium
tuberculosis) 		5 / 9 GLU A  83
VAL A  97
GLY A 129
GLN A 175
LEU A 170
 CO  A2001 (-2.5A)
None
None
CO  A2001 (-2.7A)
None
 1.27A 6cdqA-1fx7A:
0.0		 6cdqA-1fx7A:
17.37