SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4001_1
(SERUM ALBUMIN)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		4 / 4 ARG A 289
LYS A 291
ASP A 306
GLY A 304
 ARG  A 289 ( 0.6A)
LYS  A 291 ( 0.0A)
ASP  A 306 ( 0.5A)
GLY  A 304 ( 0.0A)
 1.28A 1e7bB-1fxjA:
0.0		 1e7bB-1fxjA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		4 / 5 ARG A 289
LYS A 291
ASP A 306
GLY A 304
 ARG  A 289 ( 0.6A)
LYS  A 291 ( 0.0A)
ASP  A 306 ( 0.5A)
GLY  A 304 ( 0.0A)
 1.19A 1e7cA-1fxjA:
undetectable		 1e7cA-1fxjA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 9 ILE A 202
GLY A 127
ILE A 174
ILE A 198
ILE A 201
 ILE  A 202 ( 0.7A)
GLY  A 127 ( 0.0A)
ILE  A 174 ( 0.7A)
ILE  A 198 ( 0.4A)
ILE  A 201 ( 0.6A)
 0.94A 1hshB-1fxjA:
undetectable		 1hshB-1fxjA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 8 ILE A 292
LEU A 286
ILE A 303
VAL A 315
ILE A 309
 ILE  A 292 ( 0.7A)
LEU  A 286 ( 0.6A)
ILE  A 303 ( 0.7A)
VAL  A 315 ( 0.6A)
ILE  A 309 ( 0.7A)
 1.35A 1linA-1fxjA:
undetectable		 1linA-1fxjA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		4 / 7 PHE A 260
VAL A 284
VAL A 272
ILE A 274
 PHE  A 260 ( 1.3A)
VAL  A 284 ( 0.6A)
VAL  A 272 ( 0.6A)
ILE  A 274 ( 0.7A)
 0.96A 1p7rA-1fxjA:
0.0		 1p7rA-1fxjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 12 LEU A 133
GLY A 138
ILE A 152
VAL A 131
ILE A 168
 LEU  A 133 ( 0.6A)
GLY  A 138 ( 0.0A)
ILE  A 152 ( 0.7A)
VAL  A 131 ( 0.6A)
ILE  A 168 ( 0.6A)
 0.92A 2f8gB-1fxjA:
undetectable		 2f8gB-1fxjA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 11 ILE A 202
GLU A 154
GLY A 171
THR A 170
THR A 199
 ILE  A 202 ( 0.7A)
GLU  A 154 ( 0.6A)
GLY  A 171 ( 0.0A)
THR  A 170 ( 0.8A)
THR  A 199 ( 0.8A)
 1.23A 2fn1B-1fxjA:
undetectable		 2fn1B-1fxjA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 12 VAL A 314
ILE A 303
LEU A 266
ALA A 318
SER A 301
 VAL  A 314 ( 0.6A)
ILE  A 303 ( 0.7A)
LEU  A 266 ( 0.6A)
ALA  A 318 ( 0.0A)
SER  A 301 ( 0.0A)
 1.28A 2iyfB-1fxjA:
2.4		 2iyfB-1fxjA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 9 LEU A 184
ILE A 212
GLY A 127
ILE A 174
ILE A 201
 LEU  A 184 ( 0.6A)
ILE  A 212 ( 0.7A)
GLY  A 127 ( 0.0A)
ILE  A 174 ( 0.7A)
ILE  A 201 ( 0.6A)
 1.16A 2r5qA-1fxjA:
undetectable		 2r5qA-1fxjA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 9 LEU A 184
ILE A 212
GLY A 127
ILE A 174
ILE A 201
 LEU  A 184 ( 0.6A)
ILE  A 212 ( 0.7A)
GLY  A 127 ( 0.0A)
ILE  A 174 ( 0.7A)
ILE  A 201 ( 0.6A)
 1.16A 2r5qC-1fxjA:
undetectable		 2r5qC-1fxjA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		4 / 5 ARG A 237
ASP A 261
ILE A 279
GLU A 236
 ARG  A 237 ( 0.6A)
ASP  A 261 ( 0.6A)
ILE  A 279 ( 0.7A)
GLU  A 236 ( 0.6A)
 1.40A 2xrzA-1fxjA:
0.4
2xrzB-1fxjA:
0.3		 2xrzA-1fxjA:
20.79
2xrzB-1fxjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 12 THR A 170
THR A 130
GLU A 167
LEU A 173
ILE A 202
 THR  A 170 ( 0.8A)
THR  A 130 ( 0.8A)
GLU  A 167 ( 0.5A)
LEU  A 173 ( 0.6A)
ILE  A 202 ( 0.7A)
 1.22A 3gwxB-1fxjA:
undetectable		 3gwxB-1fxjA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		3 / 3 ALA A 178
ARG A 182
LYS A 186
 ALA  A 178 ( 0.0A)
ARG  A 182 ( 0.6A)
LYS  A 186 ( 0.0A)
 1.03A 3kp3B-1fxjA:
0.1		 3kp3B-1fxjA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		3 / 3 ALA A 178
ARG A 182
LYS A 186
 ALA  A 178 ( 0.0A)
ARG  A 182 ( 0.6A)
LYS  A 186 ( 0.0A)
 0.57A 3kp5B-1fxjA:
0.0		 3kp5B-1fxjA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		3 / 3 GLU A 236
LEU A  30
LEU A  23
 GLU  A 236 ( 0.6A)
LEU  A  30 ( 0.6A)
LEU  A  23 ( 0.6A)
 0.70A 3ohtA-1fxjA:
undetectable		 3ohtA-1fxjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		3 / 3 GLU A 236
LEU A  30
LEU A  23
 GLU  A 236 ( 0.6A)
LEU  A  30 ( 0.6A)
LEU  A  23 ( 0.6A)
 0.67A 3ohtB-1fxjA:
undetectable		 3ohtB-1fxjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 12 LEU A 133
GLY A 138
ILE A 152
VAL A 131
ILE A 168
 LEU  A 133 ( 0.6A)
GLY  A 138 ( 0.0A)
ILE  A 152 ( 0.7A)
VAL  A 131 ( 0.6A)
ILE  A 168 ( 0.6A)
 1.02A 3oxxC-1fxjA:
undetectable		 3oxxC-1fxjA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 12 LEU A 100
ALA A  89
ILE A 198
LEU A  11
VAL A  54
 LEU  A 100 ( 0.6A)
ALA  A  89 ( 0.0A)
ILE  A 198 ( 0.4A)
LEU  A  11 (-0.6A)
VAL  A  54 ( 0.6A)
 1.18A 3w67C-1fxjA:
0.8		 3w67C-1fxjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 9 ILE A 109
GLN A 115
LEU A 114
VAL A 215
LEU A 129
 ILE  A 109 ( 0.4A)
GLN  A 115 ( 0.6A)
LEU  A 114 ( 0.6A)
VAL  A 215 ( 0.6A)
LEU  A 129 ( 0.6A)
 1.22A 4g1bC-1fxjA:
2.9		 4g1bC-1fxjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 11 VAL A 314
ILE A 303
LEU A 266
ALA A 318
SER A 301
 VAL  A 314 ( 0.6A)
ILE  A 303 ( 0.7A)
LEU  A 266 ( 0.6A)
ALA  A 318 ( 0.0A)
SER  A 301 ( 0.0A)
 1.28A 4m83A-1fxjA:
undetectable		 4m83A-1fxjA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 12 ASP A 200
ILE A 201
ILE A 198
GLY A 171
ILE A 202
 ASP  A 200 ( 0.6A)
ILE  A 201 ( 0.6A)
ILE  A 198 ( 0.4A)
GLY  A 171 ( 0.0A)
ILE  A 202 ( 0.7A)
 1.01A 4q1yB-1fxjA:
undetectable		 4q1yB-1fxjA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		5 / 12 VAL A 131
LEU A 114
LEU A 102
ILE A 172
VAL A 106
 VAL  A 131 ( 0.6A)
LEU  A 114 ( 0.6A)
LEU  A 102 ( 0.6A)
ILE  A 172 ( 0.7A)
VAL  A 106 ( 0.6A)
 0.95A 4y0sA-1fxjA:
0.0		 4y0sA-1fxjA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		4 / 6 THR A 285
VAL A 284
VAL A 290
HIS A 268
 THR  A 285 ( 0.8A)
VAL  A 284 ( 0.6A)
VAL  A 290 ( 0.6A)
HIS  A 268 ( 1.0A)
 1.04A 5eclA-1fxjA:
0.6		 5eclA-1fxjA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		4 / 6 ILE A 303
THR A 285
VAL A 284
VAL A 272
 ILE  A 303 ( 0.7A)
THR  A 285 ( 0.8A)
VAL  A 284 ( 0.6A)
VAL  A 272 ( 0.6A)
 0.89A 5eclD-1fxjA:
0.0		 5eclD-1fxjA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		4 / 6 TYR A 239
GLU A 242
GLN A 243
LYS A 246
 TYR  A 239 ( 1.3A)
GLU  A 242 ( 0.6A)
GLN  A 243 ( 0.6A)
LYS  A 246 ( 0.0A)
 1.02A 6d8pA-1fxjA:
0.0		 6d8pA-1fxjA:
18.22