SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD
(Homo
sapiens) 		5 / 7 LEU A 186
GLY A 167
ILE A 156
VAL A 200
ILE A 198
 None
 1.12A 2aojB-1fxlA:
undetectable		 2aojB-1fxlA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD
(Homo
sapiens) 		5 / 9 LEU A 186
GLY A 167
ILE A 156
VAL A 200
ILE A 198
 None
 1.07A 2avoA-1fxlA:
undetectable		 2avoA-1fxlA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD
(Homo
sapiens) 		5 / 9 LEU A 186
GLY A 167
ILE A 156
VAL A 200
ILE A 198
 None
 1.08A 3d1yB-1fxlA:
undetectable		 3d1yB-1fxlA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD
(Homo
sapiens) 		4 / 5 ARG A  56
ILE A  65
TYR A  87
THR A  39
 None
 1.28A 3dgqA-1fxlA:
0.0		 3dgqA-1fxlA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD
(Homo
sapiens) 		4 / 8 LEU A  58
VAL A 112
VAL A  85
LEU A 103
 None
 1.08A 4pwdC-1fxlA:
2.7		 4pwdC-1fxlA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD
(Homo
sapiens) 		4 / 8 LEU A  58
VAL A 112
VAL A  85
LEU A 103
 None
 1.17A 4q0bA-1fxlA:
3.1		 4q0bA-1fxlA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD
(Homo
sapiens) 		3 / 3 MET A  50
GLU A  54
LEU A  58
 None
 0.81A 4v2oB-1fxlA:
undetectable		 4v2oB-1fxlA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD
(Homo
sapiens) 		3 / 3 MET A 136
GLU A 140
LEU A 144
 None
 0.79A 4v2oB-1fxlA:
undetectable		 4v2oB-1fxlA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD
(Homo
sapiens) 		5 / 9 LEU A 186
GLY A 167
ILE A 156
VAL A 200
ILE A 198
 None
 1.01A 5kr2D-1fxlA:
undetectable		 5kr2D-1fxlA:
23.42