SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		8 / 8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-3.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.59A 1aq7A-1fxyA:
37.7		 1aq7A-1fxyA:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.47A 1bcuH-1fxyA:
18.3		 1bcuH-1fxyA:
37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.3A)
 0.56A 1dwcH-1fxyA:
32.6		 1dwcH-1fxyA:
37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		7 / 12 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.67A 1etrH-1fxyA:
32.6		 1etrH-1fxyA:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.38A 1f5lA-1fxyA:
11.5		 1f5lA-1fxyA:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		4 / 8 ASP A 102
PHE A  94
SER A 195
ALA A 104
 None
None
0G6  A   1 (-1.4A)
None
 1.06A 1rqpC-1fxyA:
undetectable		 1rqpC-1fxyA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.29A 1tnlA-1fxyA:
38.1		 1tnlA-1fxyA:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.25A 2otvA-1fxyA:
38.2		 2otvA-1fxyA:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		8 / 12 TYR A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 0G6  A   1 (-4.0A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
None
 0.55A 2p16A-1fxyA:
35.8		 2p16A-1fxyA:
65.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.32A 2vinA-1fxyA:
10.6		 2vinA-1fxyA:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		8 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
None
0G6  A   1 (-3.3A)
None
 0.41A 2w26A-1fxyA:
12.5		 2w26A-1fxyA:
65.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		8 / 12 TYR A  99
ASP A 189
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 0G6  A   1 (-4.0A)
0G6  A   1 (-2.8A)
None
None
0G6  A   1 (-3.9A)
None
0G6  A   1 (-3.3A)
None
 0.54A 2w26A-1fxyA:
12.5		 2w26A-1fxyA:
65.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		3 / 3 GLY A 197
GLY A 193
GLY A  43
 None
0G6  A   1 (-3.7A)
None
 0.38A 3bogC-1fxyA:
undetectable		 3bogC-1fxyA:
18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		8 / 11 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-3.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.48A 3gy3A-1fxyA:
37.0		 3gy3A-1fxyA:
55.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		3 / 3 VAL A 227
VAL A 213
TRP A 215
 None
 0.96A 3l8lC-1fxyA:
undetectable
3l8lD-1fxyA:
undetectable		 3l8lC-1fxyA:
5.94
3l8lD-1fxyA:
6.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		6 / 6 SER A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.35A 3rxfA-1fxyA:
38.1		 3rxfA-1fxyA:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		5 / 5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.3A)
 0.33A 3rxhA-1fxyA:
38.0		 3rxhA-1fxyA:
55.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		5 / 11 ALA A 121
VAL A 200
VAL A  27
ALA A  31
LEU A 209
 None
 1.02A 3sm2B-1fxyA:
undetectable		 3sm2B-1fxyA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
 0G6  A   1 (-2.7A)
0G6  A   1 (-3.8A)
0G6  A   1 (-3.7A)
0G6  A   1 (-1.4A)
 0.88A 4fu8A-1fxyA:
33.1		 4fu8A-1fxyA:
34.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		5 / 12 HIS A  57
ASP A 189
VAL A 213
TRP A 215
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
None
None
0G6  A   1 (-3.3A)
 0.35A 4hfpD-1fxyA:
32.7		 4hfpD-1fxyA:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		5 / 12 HIS A  57
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.36A 4rn6B-1fxyA:
27.3		 4rn6B-1fxyA:
36.82