SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fy1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		5 / 9 GLY A 168
GLY A   4
GLY A 129
GLY A 127
ASP A 174
 None
NAG  A1451 ( 4.8A)
None
None
None
 1.14A 1mxdA-1fy1A:
0.0		 1mxdA-1fy1A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		5 / 9 GLY A 197
GLY A   3
GLY A 129
GLY A 127
ASP A 174
 None
 1.22A 1mxdA-1fy1A:
0.0		 1mxdA-1fy1A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 THR A 177
THR A  38
ASP A  89
ASN A  86
 None
 0.98A 2okcA-1fy1A:
undetectable		 2okcA-1fy1A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 MET A  91
MET A  76
GLY A  28
GLY A  27
LEU A  95
 None
 0.95A 2uvnA-1fy1A:
undetectable		 2uvnA-1fy1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 MET A  91
MET A  76
THR A  38
GLY A  28
LEU A  95
 None
 1.07A 2uvnA-1fy1A:
undetectable		 2uvnA-1fy1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		5 / 11 MET A  91
MET A  76
THR A  38
GLY A  28
LEU A  95
 None
 1.14A 2uvnB-1fy1A:
0.0		 2uvnB-1fy1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		5 / 11 SER A  75
SER A  74
LEU A  30
SER A  72
LEU A  95
 None
 1.06A 2xn5A-1fy1A:
0.0		 2xn5A-1fy1A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		3 / 3 GLU A  64
SER A 104
VAL A 105
 None
EOH  A 300 ( 4.8A)
None
 0.68A 3eeoA-1fy1A:
undetectable		 3eeoA-1fy1A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 THR A 147
THR A 161
THR A 149
ILE A   1
LEU A 179
 None
 1.12A 3gwxA-1fy1A:
undetectable		 3gwxA-1fy1A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		3 / 3 PHE A  35
SER A  75
SER A  77
 None
 0.97A 3ufgB-1fy1A:
0.0		 3ufgB-1fy1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		5 / 11 ALA A  29
LEU A 108
PHE A  14
PHE A 203
ILE A 170
 None
 1.49A 4claA-1fy1A:
0.0		 4claA-1fy1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		5 / 11 ALA A  29
LEU A 108
PHE A  14
VAL A 146
ILE A 170
 None
 1.10A 4claA-1fy1A:
0.0		 4claA-1fy1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA608_0
(SERUM ALBUMIN)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		4 / 4 PRO A 200
ASP A 201
LEU A 193
ARG A 198
 None
 1.47A 4luhA-1fy1A:
undetectable		 4luhA-1fy1A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		6 / 12 GLY A 129
GLY A  28
GLY A 176
GLY A 173
THR A  38
VAL A  36
 None
 1.27A 5eiwC-1fy1A:
undetectable		 5eiwC-1fy1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		4 / 5 SER A  17
VAL A  54
GLY A  56
ALA A  57
 None
None
EOH  A 300 (-4.8A)
None
 1.08A 5k50A-1fy1A:
0.0		 5k50A-1fy1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 187
THR A 204
VAL A 159
VAL A 180
LEU A 179
 None
 1.19A 5kocB-1fy1A:
undetectable		 5kocB-1fy1A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 176
GLY A 127
ALA A   7
GLN A  11
ALA A 126
 None
 1.20A 5x7fA-1fy1A:
undetectable		 5x7fA-1fy1A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		3 / 3 VAL A  54
ALA A  57
GLN A  19
 None
 0.63A 6gb9A-1fy1A:
undetectable		 6gb9A-1fy1A:
21.46