SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fy2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 12 ILE A  82
LEU A  21
LEU A   6
LEU A   4
ILE A 117
 None
 1.30A 1g5yB-1fy2A:
0.0		 1g5yB-1fy2A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 12 THR A  90
GLY A  87
GLY A  86
GLY A 118
PHE A  91
 None
 1.22A 1wg8A-1fy2A:
2.4		 1wg8A-1fy2A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 12 THR A  90
GLY A  87
GLY A  86
GLY A 118
PHE A  91
 None
 1.20A 1wg8B-1fy2A:
undetectable		 1wg8B-1fy2A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 8 GLY A  87
GLY A  88
SER A 120
ALA A 121
HIS A 157
 None
 0.69A 1yajC-1fy2A:
undetectable		 1yajC-1fy2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 8 GLY A  87
GLY A  88
SER A 120
ALA A 121
HIS A 157
 None
 1.08A 1yajC-1fy2A:
undetectable		 1yajC-1fy2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 11 PHE A 150
ILE A 154
THR A 129
ALA A 146
VAL A 198
 None
 1.39A 2gl0B-1fy2A:
0.0
2gl0C-1fy2A:
0.0		 2gl0B-1fy2A:
24.03
2gl0C-1fy2A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 12 ILE A 154
THR A 129
ALA A 146
VAL A 198
PHE A 150
 None
 1.43A 2gl0A-1fy2A:
0.0
2gl0C-1fy2A:
0.0		 2gl0A-1fy2A:
24.03
2gl0C-1fy2A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 12 PHE A 150
ILE A 154
THR A 129
ALA A 146
VAL A 198
 None
 1.44A 2gl0D-1fy2A:
0.0
2gl0E-1fy2A:
undetectable		 2gl0D-1fy2A:
24.03
2gl0E-1fy2A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 11 PHE A 150
ILE A 154
THR A 129
ALA A 146
VAL A 198
 None
 1.47A 2gl0E-1fy2A:
0.0
2gl0F-1fy2A:
0.0		 2gl0E-1fy2A:
24.03
2gl0F-1fy2A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 11 ILE A 154
THR A 129
ALA A 146
VAL A 198
PHE A 150
 None
 1.43A 2gl0D-1fy2A:
0.0
2gl0F-1fy2A:
0.0		 2gl0D-1fy2A:
24.03
2gl0F-1fy2A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 12 TYR A 116
LEU A 103
ILE A  37
ILE A 154
LEU A   5
 None
 1.16A 2jn3A-1fy2A:
undetectable		 2jn3A-1fy2A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 12 GLY A  88
GLY A 118
GLY A  86
ILE A  83
LEU A 149
 None
 1.03A 2zbpA-1fy2A:
3.3		 2zbpA-1fy2A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 12 ALA A 123
PHE A 150
LEU A 152
GLY A 207
LEU A 223
 None
 1.03A 4kykA-1fy2A:
0.8
4kykB-1fy2A:
0.9		 4kykA-1fy2A:
20.25
4kykB-1fy2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		3 / 3 VAL A  85
ALA A  40
PHE A  36
 None
 0.93A 4olbA-1fy2A:
0.0		 4olbA-1fy2A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 11 LEU A  94
VAL A  85
LEU A 103
LEU A 147
ALA A 146
 None
 1.15A 4p65B-1fy2A:
undetectable
4p65D-1fy2A:
undetectable
4p65G-1fy2A:
undetectable
4p65H-1fy2A:
undetectable		 4p65B-1fy2A:
8.10
4p65D-1fy2A:
8.10
4p65G-1fy2A:
8.59
4p65H-1fy2A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		3 / 3 ALA A 220
TRP A 212
VAL A 213
 None
 0.35A 4w9nC-1fy2A:
2.5		 4w9nC-1fy2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 12 GLY A  61
PHE A  36
GLY A  41
GLY A  87
LEU A  17
 None
 0.97A 5eqbA-1fy2A:
0.0		 5eqbA-1fy2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 12 ILE A 196
ILE A 154
LEU A 190
SER A 199
VAL A 198
 None
 1.22A 5km9B-1fy2A:
undetectable		 5km9B-1fy2A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 10 ILE A  82
LEU A 115
LEU A  23
ALA A  20
LEU A   6
 None
 1.07A 5y7pB-1fy2A:
0.0		 5y7pB-1fy2A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1fy2 ASPARTYL DIPEPTIDASE
(Salmonella
enterica) 		5 / 10 ILE A  67
ILE A 130
ALA A 146
LEU A 147
ALA A 107
 None
 1.38A 5zjiB-1fy2A:
undetectable		 5zjiB-1fy2A:
17.17