SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1fyh INTERFERON GAMMA
INTERFERON GAMMA
RECEPTOR 1
(Homo
sapiens) 		4 / 8 ARG B 106
HIS A 311
SER B  80
ALA B 103
 None
 0.86A 2rk8A-1fyhB:
undetectable		 2rk8A-1fyhB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1fyh INTERFERON GAMMA
INTERFERON GAMMA
RECEPTOR 1
(Homo
sapiens) 		4 / 8 LYS A  12
HIS A 311
SER B  80
ALA B 103
 None
 1.32A 2rk8A-1fyhA:
2.3		 2rk8A-1fyhA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 1fyh INTERFERON GAMMA
INTERFERON GAMMA
RECEPTOR 1
(Homo
sapiens) 		4 / 7 ASP A  24
SER B  54
LYS B  47
GLU B  45
 None
 1.09A 3bc9A-1fyhA:
undetectable		 3bc9A-1fyhA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 1fyh INTERFERON GAMMA
(Homo
sapiens) 		4 / 6 PHE A 292
PHE A 254
ASN A 278
PHE A 281
 None
 1.13A 3t3sB-1fyhA:
0.0		 3t3sB-1fyhA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1fyh INTERFERON GAMMA
INTERFERON GAMMA
RECEPTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 GLY A  26
GLY B  50
TYR B  49
ASN B  79
 None
 1.09A 4fgkB-1fyhA:
undetectable		 4fgkB-1fyhA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 1fyh INTERFERON GAMMA
(Homo
sapiens) 		4 / 5 LEU A  33
ARG A  42
ILE A 244
ASN A  78
 None
 0.92A 4i00A-1fyhA:
undetectable		 4i00A-1fyhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 1fyh INTERFERON GAMMA
(Homo
sapiens) 		4 / 5 LEU A 233
ARG A 242
ILE A  44
ASN A 278
 None
 1.20A 4i00A-1fyhA:
undetectable		 4i00A-1fyhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1fyh INTERFERON GAMMA
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ILE B 170
GLY B 202
ILE B 110
ARG B 153
HIS B 130
 None
 1.04A 4iv0B-1fyhB:
undetectable		 4iv0B-1fyhB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 1fyh INTERFERON GAMMA
(Homo
sapiens) 		3 / 3 LEU A  95
MET A 245
ASP A 111
 None
 0.74A 4j7xB-1fyhA:
undetectable		 4j7xB-1fyhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1fyh INTERFERON GAMMA
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ILE B 170
GLY B 202
ILE B 110
ARG B 153
HIS B 130
 None
 1.06A 4mwzA-1fyhB:
undetectable		 4mwzA-1fyhB:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 1fyh INTERFERON GAMMA
RECEPTOR 1
(Homo
sapiens) 		5 / 12 LEU B 185
ILE B 187
ILE B 124
ILE B 117
VAL B 198
 None
 0.80A 4y0pA-1fyhB:
0.4		 4y0pA-1fyhB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1fyh INTERFERON GAMMA
RECEPTOR 1
(Homo
sapiens) 		3 / 3 LYS B 174
LEU B 171
ARG B 153
 None
 0.68A 5yw0A-1fyhB:
0.0		 5yw0A-1fyhB:
20.31