SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1fym HEAT SHOCK
TRANSCRIPTION
PROTEIN
(Kluyveromyces
lactis) 		4 / 7 LEU A 201
PHE A 197
LEU A 252
PHE A 278
 None
 1.00A 3asnP-1fymA:
undetectable
3asnW-1fymA:
undetectable		 3asnP-1fymA:
13.90
3asnW-1fymA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1fym HEAT SHOCK
TRANSCRIPTION
PROTEIN
(Kluyveromyces
lactis) 		4 / 7 LEU A 201
PHE A 197
LEU A 252
PHE A 278
 None
 1.01A 3asoP-1fymA:
undetectable
3asoW-1fymA:
undetectable		 3asoP-1fymA:
13.90
3asoW-1fymA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fym HEAT SHOCK
TRANSCRIPTION
PROTEIN
(Kluyveromyces
lactis) 		4 / 6 LEU A 201
PHE A 197
LEU A 252
PHE A 278
 None
 1.00A 3wg7C-1fymA:
undetectable
3wg7J-1fymA:
undetectable		 3wg7C-1fymA:
13.90
3wg7J-1fymA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 1fym HEAT SHOCK
TRANSCRIPTION
PROTEIN
(Kluyveromyces
lactis) 		3 / 3 ASN A 244
ALA A 246
ARG A 250
 None
 0.64A 5cvtB-1fymA:
undetectable		 5cvtB-1fymA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fym HEAT SHOCK
TRANSCRIPTION
PROTEIN
(Kluyveromyces
lactis) 		4 / 7 LEU A 201
PHE A 197
LEU A 252
PHE A 278
 None
 1.02A 5x1fP-1fymA:
undetectable
5x1fW-1fymA:
undetectable		 5x1fP-1fymA:
13.90
5x1fW-1fymA:
16.13