SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1fzd FIBRINOGEN-420
(Homo
sapiens) 		5 / 10 ALA A 795
ALA A 746
LEU A 709
MET A 839
VAL A 707
 None
 1.19A 2wuzA-1fzdA:
undetectable		 2wuzA-1fzdA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1fzd FIBRINOGEN-420
(Homo
sapiens) 		5 / 10 ALA A 795
ALA A 746
LEU A 709
MET A 839
VAL A 707
 None
 1.16A 2wuzB-1fzdA:
undetectable		 2wuzB-1fzdA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 1fzd FIBRINOGEN-420
(Homo
sapiens) 		4 / 7 PHE A 666
GLY A 800
GLY A 662
PHE A 766
 None
 0.84A 3ko0M-1fzdA:
undetectable
3ko0P-1fzdA:
undetectable		 3ko0M-1fzdA:
18.56
3ko0P-1fzdA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1fzd FIBRINOGEN-420
(Homo
sapiens) 		3 / 3 ALA A 836
ARG A 838
LYS A 840
 None
 1.06A 3kp5B-1fzdA:
undetectable		 3kp5B-1fzdA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1fzd FIBRINOGEN-420
(Homo
sapiens) 		5 / 12 ALA A 796
GLY A 750
SER A 751
ASP A 745
LEU A 747
 None
 1.35A 3ou6D-1fzdA:
undetectable		 3ou6D-1fzdA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1fzd FIBRINOGEN-420
(Homo
sapiens) 		5 / 12 VAL A 736
VAL A 707
LEU A 705
GLY A 744
LEU A 747
 None
 1.31A 3pghA-1fzdA:
undetectable		 3pghA-1fzdA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1fzd FIBRINOGEN-420
(Homo
sapiens) 		3 / 3 ASP A 661
GLU A 685
GLY A 686
 None
 0.60A 3w9tA-1fzdA:
0.0		 3w9tA-1fzdA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 1fzd FIBRINOGEN-420
(Homo
sapiens) 		4 / 7 VAL A 707
VAL A 736
PHE A 723
ILE A 656
 None
 0.95A 3zjqA-1fzdA:
undetectable		 3zjqA-1fzdA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 1fzd FIBRINOGEN-420
(Homo
sapiens) 		4 / 7 VAL A 707
VAL A 736
PHE A 723
ILE A 656
 None
 0.95A 3zjqB-1fzdA:
undetectable		 3zjqB-1fzdA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 1fzd FIBRINOGEN-420
(Homo
sapiens) 		5 / 11 ASP A 711
ALA A 713
ASP A 831
TYR A 832
GLY A 829
 None
 1.04A 4xp4A-1fzdA:
undetectable		 4xp4A-1fzdA:
16.91