SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fzq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		5 / 9 ILE A  89
LEU A  10
VAL A 166
GLY A 169
LEU A  37
 None
 1.08A 1e7aB-1fzqA:
undetectable		 1e7aB-1fzqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		5 / 9 ILE A  89
LEU A  10
VAL A 166
GLY A 169
LEU A  37
 None
 1.12A 1e7bA-1fzqA:
undetectable		 1e7bA-1fzqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		5 / 9 LEU A 122
VAL A 166
GLY A 165
ALA A 160
LEU A  33
 None
None
None
GDP  A 301 (-3.7A)
None
 0.93A 1e7bA-1fzqA:
undetectable		 1e7bA-1fzqA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		3 / 3 ARG A 149
VAL A 152
TRP A 153
 None
MES  A 201 (-3.8A)
MES  A 201 (-4.1A)
 1.21A 1qwcA-1fzqA:
0.0		 1qwcA-1fzqA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		4 / 7 SER A  94
PHE A 100
GLY A 104
ILE A 148
 None
 1.06A 2bdmA-1fzqA:
undetectable		 2bdmA-1fzqA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		5 / 10 ILE A  87
ILE A  89
VAL A  91
GLY A  24
LEU A 116
 None
 1.10A 3em0A-1fzqA:
0.3		 3em0A-1fzqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		4 / 7 LEU A  37
GLN A 154
LEU A 107
VAL A  91
 None
MES  A 201 (-4.0A)
None
None
 0.92A 3g8iA-1fzqA:
undetectable		 3g8iA-1fzqA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		4 / 6 LEU A 110
LEU A  88
ILE A  89
THR A  85
 None
 0.96A 4do3B-1fzqA:
0.0		 4do3B-1fzqA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		5 / 12 LEU A  63
ILE A  20
GLY A  60
SER A  58
LEU A   7
 None
 0.99A 4lmnA-1fzqA:
undetectable		 4lmnA-1fzqA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		4 / 6 ASP A  26
THR A  46
PRO A  47
THR A  48
 None
 1.04A 4yoaA-1fzqA:
0.0		 4yoaA-1fzqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		3 / 3 ARG A 149
VAL A 152
TRP A 153
 None
MES  A 201 (-3.8A)
MES  A 201 (-4.1A)
 1.23A 5fvoA-1fzqA:
undetectable		 5fvoA-1fzqA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		4 / 6 ARG A  75
GLU A 113
PHE A  82
GLU A 106
 None
 1.29A 5h4dA-1fzqA:
4.8		 5h4dA-1fzqA:
20.14