SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.13A 1fkpA-1fztA:
undetectable		 1fkpA-1fztA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		4 / 7 THR A  27
LEU A  99
GLY A 101
LYS A 104
 None
 0.74A 1gtiD-1fztA:
0.0		 1gtiD-1fztA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		4 / 7 THR A  27
LEU A  99
GLY A 101
LYS A 104
 None
 1.00A 1gtiE-1fztA:
0.0		 1gtiE-1fztA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		4 / 5 THR A  27
LEU A  99
GLY A 101
LYS A 104
 None
 0.86A 1gtiF-1fztA:
0.0		 1gtiF-1fztA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.20A 1lw0A-1fztA:
undetectable		 1lw0A-1fztA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.20A 1lwcA-1fztA:
undetectable		 1lwcA-1fztA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.17A 1lwfA-1fztA:
undetectable		 1lwfA-1fztA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 159
VAL A  78
GLY A  46
LEU A  83
 None
 1.04A 1s1xA-1fztA:
undetectable		 1s1xA-1fztA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.16A 1vrtA-1fztA:
undetectable		 1vrtA-1fztA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.21A 2hndA-1fztA:
undetectable		 2hndA-1fztA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.19A 2hnyA-1fztA:
undetectable		 2hnyA-1fztA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A  74
ILE A 148
ILE A  58
THR A  85
LEU A  83
 None
 1.05A 2qo5A-1fztA:
0.0		 2qo5A-1fztA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 9 ALA A 169
LEU A 141
ILE A 148
ILE A 160
TYR A 195
 None
 1.31A 3jw3B-1fztA:
undetectable		 3jw3B-1fztA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.24A 3lp1A-1fztA:
undetectable		 3lp1A-1fztA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 159
VAL A  78
GLY A  46
LEU A  83
PRO A  81
 None
 1.29A 3mecA-1fztA:
undetectable		 3mecA-1fztA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.20A 3qipA-1fztA:
undetectable		 3qipA-1fztA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 190
THR A 189
LEU A 187
LYS A  43
VAL A  78
 None
 0.93A 3sglA-1fztA:
undetectable		 3sglA-1fztA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 11 ALA A 161
GLY A  46
ILE A  39
VAL A  11
LEU A 159
 None
 0.89A 3zosA-1fztA:
0.0
3zosB-1fztA:
undetectable		 3zosA-1fztA:
20.81
3zosB-1fztA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.34A 4b3oA-1fztA:
undetectable		 4b3oA-1fztA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 185
ARG A 121
ILE A 171
 None
 0.84A 4b7qA-1fztA:
undetectable		 4b7qA-1fztA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 185
ARG A 121
ILE A 171
 None
 0.92A 4b7qC-1fztA:
undetectable		 4b7qC-1fztA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		4 / 8 ARG A  14
ARG A 168
GLY A  28
THR A  27
 None
 0.90A 4k87A-1fztA:
undetectable		 4k87A-1fztA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 8 VAL A 158
LEU A  10
TYR A 195
ILE A 171
VAL A 140
 None
 1.41A 4ma7A-1fztA:
undetectable		 4ma7A-1fztA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  49
GLU A 207
VAL A  11
PRO A 192
GLU A  41
 None
 1.22A 4ydqA-1fztA:
undetectable		 4ydqA-1fztA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.20A 5hbmA-1fztA:
undetectable		 5hbmA-1fztA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 209
LEU A  49
GLY A  46
GLY A  45
PRO A 192
 None
 1.06A 5wyqA-1fztA:
undetectable		 5wyqA-1fztA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1fzt PHOSPHOGLYCERATE
MUTASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  49
GLU A 207
VAL A  11
PRO A 192
GLU A  41
 None
 1.26A 5xiqA-1fztA:
undetectable		 5xiqA-1fztA:
17.51