SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 1fzy UBIQUITIN-CONJUGATIN
G ENZYME E2-24 KDA
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 122
ALA A  86
GLN A  70
ILE A  87
 None
 1.06A 2z0aA-1fzyA:
undetectable		 2z0aA-1fzyA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 1fzy UBIQUITIN-CONJUGATIN
G ENZYME E2-24 KDA
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  36
VAL A  27
HIS A  34
 None
 0.70A 3tj7A-1fzyA:
0.4		 3tj7A-1fzyA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 1fzy UBIQUITIN-CONJUGATIN
G ENZYME E2-24 KDA
(Saccharomyces
cerevisiae) 		4 / 7 THR A  73
ALA A 149
THR A 145
VAL A  75
 None
 1.00A 4ik7A-1fzyA:
0.2		 4ik7A-1fzyA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 1fzy UBIQUITIN-CONJUGATIN
G ENZYME E2-24 KDA
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  34
ASP A  31
HIS A  33
 None
 0.91A 5n1tW-1fzyA:
undetectable		 5n1tW-1fzyA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1fzy UBIQUITIN-CONJUGATIN
G ENZYME E2-24 KDA
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  37
VAL A  27
LEU A 106
VAL A  54
LEU A 109
 None
 1.20A 5ubbA-1fzyA:
undetectable		 5ubbA-1fzyA:
20.80