SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 7 SER A  28
GLU A  41
GLU A  66
GLU A  65
 None
None
None
MN  A 291 (-2.1A)
 0.99A 1knyA-1g0iA:
0.0
1knyB-1g0iA:
0.0		 1knyA-1g0iA:
24.40
1knyB-1g0iA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A  66
GLU A  65
SER A  28
GLU A  41
 None
MN  A 291 (-2.1A)
None
None
 1.11A 1knyA-1g0iA:
0.0
1knyB-1g0iA:
0.0		 1knyA-1g0iA:
24.40
1knyB-1g0iA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 208
GLY A 111
GLY A 101
LEU A 177
CYH A 180
 None
 1.20A 2qmmA-1g0iA:
undetectable		 2qmmA-1g0iA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 111
PHE A 100
ALA A 130
ALA A 183
ALA A 203
 None
 1.08A 3g8bB-1g0iA:
0.0		 3g8bB-1g0iA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A 241
ASP A 188
ASP A 246
 None
 0.92A 3iv6C-1g0iA:
undetectable		 3iv6C-1g0iA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 8 ASP A  81
ASP A  84
GLY A 176
GLU A  65
ARG A 194
 MN  A 291 (-2.4A)
MN  A 290 ( 3.3A)
None
MN  A 291 (-2.1A)
None
 1.45A 3s3mA-1g0iA:
undetectable		 3s3mA-1g0iA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  10
GLY A 111
VAL A  78
ILE A  80
VAL A  79
 None
 1.01A 4c9lA-1g0iA:
0.0		 4c9lA-1g0iA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  10
GLY A 111
VAL A  78
ILE A  80
VAL A  79
 None
 1.01A 4c9lB-1g0iA:
undetectable		 4c9lB-1g0iA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  10
GLY A 111
VAL A  78
ILE A  80
VAL A  79
 None
 1.02A 4c9oA-1g0iA:
undetectable		 4c9oA-1g0iA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  10
GLY A 111
VAL A  78
ILE A  80
VAL A  79
 None
 1.05A 4c9oB-1g0iA:
undetectable		 4c9oB-1g0iA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 4 LYS A 167
ASN A 146
VAL A 148
ASP A 188
 None
 1.26A 4fglD-1g0iA:
0.0		 4fglD-1g0iA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 7 PHE A  98
GLY A 111
VAL A  78
ILE A  80
VAL A  79
 None
 1.32A 5ik1A-1g0iA:
undetectable		 5ik1A-1g0iA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ARG A 198
VAL A 200
GLY A  37
SER A  36
THR A  33
 PO4  A 293 (-3.5A)
None
None
None
None
 1.41A 5ksnB-1g0iA:
1.5		 5ksnB-1g0iA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXS_B_NIZB806_1
(CATALASE-PEROXIDASE)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ARG A 198
VAL A 200
GLY A  37
SER A  36
THR A  33
 PO4  A 293 (-3.5A)
None
None
None
None
 1.41A 5sxsB-1g0iA:
0.0		 5sxsB-1g0iA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 1g0i INOSITOL
MONOPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 171
ASN A  88
GLU A 178
ASP A  84
TYR A 152
 None
None
None
MN  A 290 ( 3.3A)
None
 1.08A 6ekuA-1g0iA:
undetectable		 6ekuA-1g0iA:
14.51