SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		4 / 6 ILE D 196
VAL D  68
ILE D 138
ILE D  89
 None
 0.77A 1uwhA-1g0uD:
undetectable		 1uwhA-1g0uD:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 6 ILE D 196
VAL D 193
VAL D  68
ILE D 138
ILE D  89
 None
 1.47A 1uwhB-1g0uD:
0.0		 1uwhB-1g0uD:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 9 ALA D  41
TYR D 146
GLY D 145
GLY D 140
ILE D 215
 None
 1.13A 2v7bA-1g0uD:
undetectable		 2v7bA-1g0uD:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 9 ALA D  41
TYR D 146
GLY D 145
GLY D 140
ILE D 215
 None
 1.13A 2v7bB-1g0uD:
undetectable		 2v7bB-1g0uD:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 10 ILE D  38
ALA D 189
THR D 229
ILE D 233
LEU D 207
 None
 1.18A 2w3aB-1g0uD:
undetectable		 2w3aB-1g0uD:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 12 LEU D  48
ALA D 139
VAL D 116
THR D 113
VAL D 109
 None
 0.99A 3cwkA-1g0uD:
0.3		 3cwkA-1g0uD:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 12 LEU D 148
TYR D 160
GLY D  39
LEU D  48
HIS D 150
 None
 1.07A 3e23A-1g0uD:
undetectable		 3e23A-1g0uD:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 10 LYS D 163
LEU D 137
ILE D 165
SER D 167
GLY D 166
 None
 1.40A 3ik6B-1g0uD:
undetectable
3ik6E-1g0uD:
0.0		 3ik6B-1g0uD:
20.60
3ik6E-1g0uD:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 10 LYS D 163
LEU D 137
SER D 167
SER D  35
GLY D 166
 None
 1.48A 3ik6B-1g0uD:
undetectable
3ik6E-1g0uD:
0.0		 3ik6B-1g0uD:
20.60
3ik6E-1g0uD:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 10 LYS D 163
LEU D 137
ILE D 165
SER D 167
GLY D 166
 None
 1.41A 3iluB-1g0uD:
0.0
3iluE-1g0uD:
0.0		 3iluB-1g0uD:
20.60
3iluE-1g0uD:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 9 ALA D  41
TYR D 146
GLY D 145
GLY D 140
ILE D 215
 None
 1.05A 4eatB-1g0uD:
undetectable		 4eatB-1g0uD:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 11 GLN D 173
ASN D 161
LEU D 176
VAL D 193
ILE D  38
 None
 1.45A 4k37B-1g0uD:
undetectable		 4k37B-1g0uD:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 12 ALA D 189
GLY D  49
GLY D  39
LEU D 137
LYS D  66
 None
 1.06A 4lg1B-1g0uD:
undetectable		 4lg1B-1g0uD:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		3 / 3 VAL D  68
ALA D  77
PHE D 221
 None
 0.71A 4olbA-1g0uD:
0.0		 4olbA-1g0uD:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		3 / 3 VAL D  68
ALA D  77
PHE D 221
 None
 0.78A 4w5nA-1g0uD:
0.0		 4w5nA-1g0uD:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		3 / 3 VAL D  68
ALA D  77
PHE D 221
 None
 0.69A 4z4iA-1g0uD:
undetectable		 4z4iA-1g0uD:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		5 / 8 ILE D 196
VAL D 193
VAL D  68
ILE D 138
ILE D  89
 None
 1.44A 5hi2A-1g0uD:
undetectable		 5hi2A-1g0uD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1g0u PROTEASOME COMPONENT
PUP2
(Saccharomyces
cerevisiae) 		3 / 3 VAL D  68
ALA D  77
PHE D 221
 None
 0.71A 5js1A-1g0uD:
undetectable		 5js1A-1g0uD:
14.65