SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g1a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 5 SER A 170
ASN A 100
ALA A  82
GLU A  83
 None
None
NAD  A 400 (-3.2A)
None
 1.39A 1lqtA-1g1aA:
6.6
1lqtB-1g1aA:
6.1		 1lqtA-1g1aA:
22.85
1lqtB-1g1aA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 5 SER A 170
ASN A 100
ALA A  82
GLU A  83
 None
None
NAD  A 400 (-3.2A)
None
 1.38A 1lquA-1g1aA:
6.3
1lquB-1g1aA:
5.7		 1lquA-1g1aA:
22.85
1lquB-1g1aA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 LYS A 329
ILE A 280
THR A 272
 None
 0.82A 1rx3A-1g1aA:
undetectable		 1rx3A-1g1aA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 12 LEU A 207
PRO A 209
TYR A 334
THR A 330
ILE A 327
 None
 1.28A 1xoqA-1g1aA:
undetectable		 1xoqA-1g1aA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 12 LEU A 207
PRO A 209
TYR A 334
THR A 330
ILE A 327
 None
 1.29A 1xoqB-1g1aA:
undetectable		 1xoqB-1g1aA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_2
(NEURAMINIDASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 5 LEU A 320
ARG A 241
TRP A 317
ILE A 258
 None
 1.35A 2cmlA-1g1aA:
undetectable		 2cmlA-1g1aA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_2
(NEURAMINIDASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 5 LEU A 320
ARG A 241
TRP A 317
ILE A 258
 None
 1.36A 2cmlB-1g1aA:
undetectable		 2cmlB-1g1aA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_2
(NEURAMINIDASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 5 LEU A 320
ARG A 241
TRP A 317
ILE A 258
 None
 1.39A 2cmlC-1g1aA:
undetectable		 2cmlC-1g1aA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_2
(NEURAMINIDASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 5 LEU A 320
ARG A 241
TRP A 317
ILE A 258
 None
 1.33A 2cmlD-1g1aA:
undetectable		 2cmlD-1g1aA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 8 TYR A 161
ASP A 175
SER A 132
TYR A 167
 None
 1.35A 2v0gA-1g1aA:
1.3		 2v0gA-1g1aA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 GLU A 145
GLN A 229
ARG A 231
 None
 0.88A 2w3bB-1g1aA:
0.3		 2w3bB-1g1aA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 10 VAL A  77
SER A  62
ILE A  65
PHE A  69
THR A 189
 None
 1.14A 2w9gA-1g1aA:
undetectable		 2w9gA-1g1aA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 10 ALA A 106
ALA A  57
ILE A  31
LEU A   4
PHE A  69
 None
 1.17A 3fl9F-1g1aA:
undetectable		 3fl9F-1g1aA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 9 VAL A  77
SER A  62
ILE A  65
PHE A  69
THR A 189
 None
 1.16A 3freX-1g1aA:
undetectable		 3freX-1g1aA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 12 LEU A 207
PRO A 209
TYR A 334
THR A 330
ILE A 327
 None
 1.28A 3g4lC-1g1aA:
undetectable		 3g4lC-1g1aA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 6 ALA A  15
ILE A  12
HIS A 239
ASN A 197
 None
NAD  A 400 (-3.8A)
None
NAD  A 400 (-4.8A)
 1.15A 3nneG-1g1aA:
0.0		 3nneG-1g1aA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 HIS A 129
SER A 174
ASN A 193
 None
 0.72A 3s8pB-1g1aA:
undetectable		 3s8pB-1g1aA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 5 LEU A 320
ARG A 241
TRP A 317
ILE A 258
 None
 1.41A 3ticD-1g1aA:
undetectable		 3ticD-1g1aA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 HIS A  79
HIS A 130
ILE A 131
 None
 0.80A 3u52A-1g1aA:
0.0
3u52C-1g1aA:
undetectable		 3u52A-1g1aA:
21.47
3u52C-1g1aA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 12 ILE A  68
VAL A 110
LEU A 187
ILE A  59
VAL A 247
 None
None
None
NAD  A 400 (-3.7A)
None
 1.19A 3w68C-1g1aA:
0.0		 3w68C-1g1aA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 LYS A 329
ILE A 280
THR A 272
 None
 0.85A 4gh8A-1g1aA:
undetectable		 4gh8A-1g1aA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 5 LEU A 320
ARG A 241
TRP A 317
ILE A 258
 None
 1.43A 4i00A-1g1aA:
undetectable		 4i00A-1g1aA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 ASN A 196
ASP A 134
ASP A 139
 None
 0.85A 4obwD-1g1aA:
5.8		 4obwD-1g1aA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 12 LEU A 107
ALA A 111
LEU A   4
HIS A 130
LEU A 187
 None
 1.10A 4zn7A-1g1aA:
0.0		 4zn7A-1g1aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 HIS A 129
SER A 174
ASN A 193
 None
 0.69A 5cprB-1g1aA:
0.0		 5cprB-1g1aA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 6 LEU A 221
GLN A 290
LEU A 216
LEU A 277
 None
 1.08A 5yvnA-1g1aA:
0.7		 5yvnA-1g1aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 12 ASN A 214
ILE A 273
VAL A 331
THR A 330
ILE A 327
 None
 1.19A 6hlpA-1g1aA:
2.4		 6hlpA-1g1aA:
21.40