SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AV2_B_DVAB8_0 (GRAMICIDIN A)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	3 / 3	VAL A 164 VAL A 205 TRP A 168	None	0.87A	1av2A-1g38A: undetectable 1av2B-1g38A: undetectable	1av2A-1g38A: 5.10 1av2B-1g38A: 5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_E_THAE5_2 (LIVER CARBOXYLESTERASE I)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	3 / 3	PHE A 264 LEU A 371 LEU A 375	None	0.64A	1mx1E-1g38A: undetectable	1mx1E-1g38A: 23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QAO_A_SAMA245_0 (ERMC' METHYLTRANSFERASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	6 / 12	GLU A 45 ILE A 72 ASP A 73 ASP A 89 ASN A 105 PRO A 107	None NEA A 500 (-3.8A) None NEA A 500 (-3.4A) NEA A 500 (-4.5A) NEA A 500 (-3.8A)	0.82A	1qaoA-1g38A: 11.7	1qaoA-1g38A: 19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QU2_A_MRCA1993_2 (ISOLEUCYL-TRNA SYNTHETASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	3 / 3	GLU A 355 TRP A 352 LYS A 137	None	1.04A	1qu2A-1g38A: undetectable	1qu2A-1g38A: 18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 12	VAL A 27 ALA A 35 LEU A 103 ALA A 56 ALA A 60	None	1.17A	1sa1A-1g38A: undetectable 1sa1B-1g38A: undetectable	1sa1A-1g38A: 20.39 1sa1B-1g38A: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 12	VAL A 27 ALA A 35 LEU A 103 ALA A 56 ALA A 60	None	1.17A	1sa1C-1g38A: 2.1 1sa1D-1g38A: undetectable	1sa1C-1g38A: 20.39 1sa1D-1g38A: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQF_A_SAMA430_0 (SUN PROTEIN)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	6 / 12	ALA A 49 GLY A 51 ILE A 72 ASP A 73 ASP A 89 PRO A 107	NEA A 500 ( 3.7A) None NEA A 500 (-3.8A) None NEA A 500 (-3.4A) NEA A 500 (-3.8A)	0.82A	1sqfA-1g38A: 11.1	1sqfA-1g38A: 23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W5U_B_DVAB8_0 (GRAMICIDIN D)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	3 / 3	VAL A 164 VAL A 205 TRP A 168	None	0.76A	1w5uA-1g38A: undetectable 1w5uB-1g38A: undetectable	1w5uA-1g38A: 5.10 1w5uB-1g38A: 5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRK_A_TFPA204_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 9	VAL A 333 LEU A 331 MET A 380 SER A 377 LEU A 260	None	1.18A	1wrkA-1g38A: 0.0 1wrkB-1g38A: 0.0	1wrkA-1g38A: 14.05 1wrkB-1g38A: 14.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2ADM_A_SAMA500_0 (ADENINE-N6-DNA-METHY LTRANSFERASE TAQI)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	11 / 11	THR A 23 GLU A 45 ALA A 47 PRO A 52 GLU A 71 ILE A 72 ASP A 73 ALA A 76 ASP A 89 PRO A 107 PHE A 146	None None NEA A 500 (-3.1A) None NEA A 500 (-2.8A) NEA A 500 (-3.8A) None NEA A 500 ( 3.7A) NEA A 500 (-3.4A) NEA A 500 (-3.8A) None	0.28A	2admA-1g38A: 54.5	2admA-1g38A: 99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2ADM_B_SAMB500_0 (ADENINE-N6-DNA-METHY LTRANSFERASE TAQI)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	11 / 11	VAL A 21 THR A 23 GLU A 45 ALA A 47 PRO A 52 GLU A 71 ILE A 72 ALA A 76 ASP A 89 PRO A 107 PHE A 146	NEA A 500 ( 4.8A) None None NEA A 500 (-3.1A) None NEA A 500 (-2.8A) NEA A 500 (-3.8A) NEA A 500 ( 3.7A) NEA A 500 (-3.4A) NEA A 500 (-3.8A) None	0.61A	2admB-1g38A: 54.5	2admB-1g38A: 99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HS2_B_017B203_1 (PROTEASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	4 / 6	TRP A 82 LEU A 101 ARG A 58 GLY A 64	None	1.22A	2hs2B-1g38A: 0.0	2hs2B-1g38A: 12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_C_SAMC1003_0 (SAM DEPENDENT METHYLTRANSFERASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 12	PHE A 174 PHE A 146 TYR A 143 ALA A 47 TYR A 140	None None None NEA A 500 (-3.1A) None	1.31A	2igtC-1g38A: 10.0	2igtC-1g38A: 21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IZQ_C_DVAC8_0 (GRAMICIDIN D)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	3 / 3	VAL A 205 TRP A 168 VAL A 164	None	0.78A	2izqC-1g38A: undetectable 2izqD-1g38A: undetectable	2izqC-1g38A: 5.10 2izqD-1g38A: 5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_B_D16B409_1 (THYMIDYLATE SYNTHASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	4 / 8	ARG A 244 ILE A 243 TRP A 238 TYR A 140	None	0.91A	2tsrB-1g38A: undetectable	2tsrB-1g38A: 22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7H_B_SAMB530_0 (TYPE I RESTRICTION ENZYME ECOKI M PROTEIN)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 12	ALA A 47 GLY A 51 ASN A 105 PRO A 107 PHE A 146	NEA A 500 (-3.1A) None NEA A 500 (-4.5A) NEA A 500 (-3.8A) None	0.98A	2y7hB-1g38A: 18.0	2y7hB-1g38A: 21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7H_B_SAMB530_0 (TYPE I RESTRICTION ENZYME ECOKI M PROTEIN)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	6 / 12	THR A 23 ALA A 47 LEU A 91 ASN A 105 PRO A 107 PHE A 146	None NEA A 500 (-3.1A) NEA A 500 ( 4.9A) NEA A 500 (-4.5A) NEA A 500 (-3.8A) None	0.84A	2y7hB-1g38A: 18.0	2y7hB-1g38A: 21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7H_C_SAMC530_0 (TYPE I RESTRICTION ENZYME ECOKI M PROTEIN)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 12	ALA A 47 GLY A 51 ASN A 105 PRO A 107 PHE A 146	NEA A 500 (-3.1A) None NEA A 500 (-4.5A) NEA A 500 (-3.8A) None	0.98A	2y7hC-1g38A: 16.1	2y7hC-1g38A: 21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7H_C_SAMC530_0 (TYPE I RESTRICTION ENZYME ECOKI M PROTEIN)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	6 / 12	THR A 23 ALA A 47 LEU A 91 ASN A 105 PRO A 107 PHE A 146	None NEA A 500 (-3.1A) NEA A 500 ( 4.9A) NEA A 500 (-4.5A) NEA A 500 (-3.8A) None	0.84A	2y7hC-1g38A: 16.1	2y7hC-1g38A: 21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AOC_C_ERYC3402_1 (ACRIFLAVINE RESISTANCE PROTEIN B)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	3 / 3	THR A 294 SER A 272 LYS A 276	None	1.07A	3aocC-1g38A: 0.0	3aocC-1g38A: 17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CL9_A_MTXA602_2 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (DHFR-TS))	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	4 / 4	VAL A 341 ARG A 402 ILE A 266 THR A 339	None	1.02A	3cl9A-1g38A: 0.8	3cl9A-1g38A: 21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GRV_A_ADNA300_1 (DIMETHYLADENOSINE TRANSFERASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 11	GLU A 71 ILE A 72 ASP A 73 ASP A 89 PRO A 107	NEA A 500 (-2.8A) NEA A 500 (-3.8A) None NEA A 500 (-3.4A) NEA A 500 (-3.8A)	0.48A	3grvA-1g38A: 7.6	3grvA-1g38A: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GRY_A_SAMA300_0 (DIMETHYLADENOSINE TRANSFERASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	7 / 12	GLU A 45 GLU A 71 ILE A 72 ASP A 73 ASP A 89 ASN A 105 PRO A 107	None NEA A 500 (-2.8A) NEA A 500 (-3.8A) None NEA A 500 (-3.4A) NEA A 500 (-4.5A) NEA A 500 (-3.8A)	0.61A	3gryA-1g38A: 14.3	3gryA-1g38A: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JUS_B_ECNB602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 9	TYR A 190 THR A 220 PHE A 245 GLY A 193 ALA A 203	None	1.36A	3jusB-1g38A: 0.0	3jusB-1g38A: 23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8X_B_NIMB1701_2 (PROSTAGLANDIN G/H SYNTHASE 1)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	3 / 3	VAL A 170 VAL A 204 SER A 202	None	0.68A	3n8xB-1g38A: 0.0	3n8xB-1g38A: 23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A79_B_P1BB601_1 (AMINE OXIDASE [FLAVIN-CONTAINING] B)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 12	LEU A 215 ILE A 206 ILE A 243 PHE A 174 TYR A 140	None	1.45A	4a79B-1g38A: 1.5	4a79B-1g38A: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GC9_A_SAMA401_1 (DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	3 / 3	GLU A 71 ASP A 73 ASP A 89	NEA A 500 (-2.8A) None NEA A 500 (-3.4A)	0.33A	4gc9A-1g38A: 10.8	4gc9A-1g38A: 23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	4 / 8	LYS A 186 GLY A 157 GLY A 158 VAL A 159	None	0.74A	4qvvK-1g38A: undetectable 4qvvL-1g38A: undetectable	4qvvK-1g38A: 19.40 4qvvL-1g38A: 20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	4 / 8	LYS A 186 GLY A 157 GLY A 158 VAL A 159	None	0.74A	4qvvY-1g38A: undetectable 4qvvZ-1g38A: undetectable	4qvvY-1g38A: 19.40 4qvvZ-1g38A: 20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FXT_A_0LAA1376_1 (DNA POLYMERASE III SUBUNIT BETA)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	4 / 7	LYS A 149 LEU A 153 PRO A 95 ILE A 86	None	1.03A	5fxtA-1g38A: undetectable	5fxtA-1g38A: 23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JGL_A_SAMA301_0 (UBIE/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 12	THR A 413 LEU A 358 LEU A 375 PHE A 411 GLY A 410	None	1.34A	5jglA-1g38A: 13.1	5jglA-1g38A: 20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X1B_P_CHDP305_0 (CYTOCHROME C OXIDASE SUBUNIT 3)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	4 / 5	LEU A 147 PHE A 146 PHE A 162 LEU A 160	None	1.12A	5x1bP-1g38A: undetectable	5x1bP-1g38A: 18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_A_ACRA1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	4 / 6	SER A 370 ARG A 406 GLU A 408 TYR A 409	None	1.49A	5x7pA-1g38A: 0.0	5x7pA-1g38A: 14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_B_ACRB1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	4 / 6	SER A 370 ARG A 406 GLU A 408 TYR A 409	None	1.50A	5x7pB-1g38A: 0.0	5x7pB-1g38A: 14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7Q_A_ACRA1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	4 / 6	SER A 370 ARG A 406 GLU A 408 TYR A 409	None	1.49A	5x7qA-1g38A: 0.0	5x7qA-1g38A: 14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7R_A_ACRA1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	4 / 6	SER A 370 ARG A 406 GLU A 408 TYR A 409	None	1.49A	5x7rA-1g38A: 0.0	5x7rA-1g38A: 14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7R_B_ACRB1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	4 / 6	SER A 370 ARG A 406 GLU A 408 TYR A 409	None	1.47A	5x7rB-1g38A: 0.0	5x7rB-1g38A: 14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YBB_B_SAMB601_0 (TYPE I RESTRICTION-MODIFICA TION SYSTEM METHYLTRANSFERASE SUBUNIT)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 12	THR A 23 LEU A 91 ASN A 105 PRO A 107 PHE A 146	None NEA A 500 ( 4.9A) NEA A 500 (-4.5A) NEA A 500 (-3.8A) None	0.68A	5ybbB-1g38A: 18.7	5ybbB-1g38A: 23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YF9_X_NIOX401_1 (CASEIN KINASE II SUBUNIT ALPHA')	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 9	LEU A 375 VAL A 341 VAL A 333 ILE A 266 PHE A 356	None	0.89A	5yf9X-1g38A: undetectable	5yf9X-1g38A: 11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_D_ADND502_1 (ADENOSYLHOMOCYSTEINA SE)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	3 / 3	LEU A 358 ASN A 376 LEU A 298	None	0.70A	6exiD-1g38A: 4.7	6exiD-1g38A: 13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNF_A_QPSA602_1 (-)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 12	VAL A 121 ASP A 89 PHE A 90 PRO A 107 GLY A 109	None NEA A 500 (-3.4A) None NEA A 500 (-3.8A) None	1.46A	6gnfA-1g38A: undetectable	6gnfA-1g38A: 22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNF_C_QPSC602_2 (-)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	5 / 12	VAL A 121 ASP A 89 GLU A 148 PRO A 107 GLY A 109	None NEA A 500 (-3.4A) None NEA A 500 (-3.8A) None	1.41A	6gnfC-1g38A: undetectable	6gnfC-1g38A: 22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NJ9_K_SAMK500_1 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	1g38	MODIFICATION METHYLASE TAQI (Thermus aquaticus)	3 / 3	THR A 23 GLU A 71 ASN A 105	None NEA A 500 (-2.8A) NEA A 500 (-4.5A)	0.82A	6nj9K-1g38A: 10.2	6nj9K-1g38A: 23.18

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AV2_B_DVAB8_0","GRAMICIDIN A","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",3,"VAL A 164;VAL A 205;TRP A 168","None","0.87A","1av2A-1g38A:undetectable;1av2B-1g38A:undetectable","1av2A-1g38A:5.10;1av2B-1g38A:5.10"],["1MX1_E_THAE5_2","LIVER CARBOXYLESTERASE I","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",3,"PHE A 264;LEU A 371;LEU A 375","None","0.64A","1mx1E-1g38A:undetectable","1mx1E-1g38A:23.84"],["1QAO_A_SAMA245_0","ERMC' METHYLTRANSFERASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",6,"GLU A  45;ILE A  72;ASP A  73;ASP A  89;ASN A 105;PRO A 107","None;NEA A 500 (-3.8A);None;NEA A 500 (-3.4A);NEA A 500 (-4.5A);NEA A 500 (-3.8A)","0.82A","1qaoA-1g38A:11.7","1qaoA-1g38A:19.42"],["1QU2_A_MRCA1993_2","ISOLEUCYL-TRNA SYNTHETASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",3,"GLU A 355;TRP A 352;LYS A 137","None","1.04A","1qu2A-1g38A:undetectable","1qu2A-1g38A:18.26"],["1SA1_B_PODB700_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"VAL A  27;ALA A  35;LEU A 103;ALA A  56;ALA A  60","None","1.17A","1sa1A-1g38A:undetectable;1sa1B-1g38A:undetectable","1sa1A-1g38A:20.39;1sa1B-1g38A:21.18"],["1SA1_D_PODD701_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"VAL A  27;ALA A  35;LEU A 103;ALA A  56;ALA A  60","None","1.17A","1sa1C-1g38A:2.1;1sa1D-1g38A:undetectable","1sa1C-1g38A:20.39;1sa1D-1g38A:21.18"],["1SQF_A_SAMA430_0","SUN PROTEIN","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",6,"ALA A  49;GLY A  51;ILE A  72;ASP A  73;ASP A  89;PRO A 107","NEA A 500 ( 3.7A);None;NEA A 500 (-3.8A);None;NEA A 500 (-3.4A);NEA A 500 (-3.8A)","0.82A","1sqfA-1g38A:11.1","1sqfA-1g38A:23.40"],["1W5U_B_DVAB8_0","GRAMICIDIN D","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",3,"VAL A 164;VAL A 205;TRP A 168","None","0.76A","1w5uA-1g38A:undetectable;1w5uB-1g38A:undetectable","1w5uA-1g38A:5.10;1w5uB-1g38A:5.10"],["1WRK_A_TFPA204_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES;TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"VAL A 333;LEU A 331;MET A 380;SER A 377;LEU A 260","None","1.18A","1wrkA-1g38A:0.0;1wrkB-1g38A:0.0","1wrkA-1g38A:14.05;1wrkB-1g38A:14.05"],["2ADM_A_SAMA500_0","ADENINE-N6-DNA-METHYLTRANSFERASE TAQI","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",11,"THR A  23;GLU A  45;ALA A  47;PRO A  52;GLU A  71;ILE A  72;ASP A  73;ALA A  76;ASP A  89;PRO A 107;PHE A 146","None;None;NEA A 500 (-3.1A);None;NEA A 500 (-2.8A);NEA A 500 (-3.8A);None;NEA A 500 ( 3.7A);NEA A 500 (-3.4A);NEA A 500 (-3.8A);None","0.28A","2admA-1g38A:54.5","2admA-1g38A:99.75"],["2ADM_B_SAMB500_0","ADENINE-N6-DNA-METHYLTRANSFERASE TAQI","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",11,"VAL A  21;THR A  23;GLU A  45;ALA A  47;PRO A  52;GLU A  71;ILE A  72;ALA A  76;ASP A  89;PRO A 107;PHE A 146","NEA A 500 ( 4.8A);None;None;NEA A 500 (-3.1A);None;NEA A 500 (-2.8A);NEA A 500 (-3.8A);NEA A 500 ( 3.7A);NEA A 500 (-3.4A);NEA A 500 (-3.8A);None","0.61A","2admB-1g38A:54.5","2admB-1g38A:99.75"],["2HS2_B_017B203_1","PROTEASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",4,"TRP A  82;LEU A 101;ARG A  58;GLY A  64","None","1.22A","2hs2B-1g38A:0.0","2hs2B-1g38A:12.53"],["2IGT_C_SAMC1003_0","SAM DEPENDENT METHYLTRANSFERASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"PHE A 174;PHE A 146;TYR A 143;ALA A  47;TYR A 140","None;None;None;NEA A 500 (-3.1A);None","1.31A","2igtC-1g38A:10.0","2igtC-1g38A:21.95"],["2IZQ_C_DVAC8_0","GRAMICIDIN D","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",3,"VAL A 205;TRP A 168;VAL A 164","None","0.78A","2izqC-1g38A:undetectable;2izqD-1g38A:undetectable","2izqC-1g38A:5.10;2izqD-1g38A:5.10"],["2TSR_B_D16B409_1","THYMIDYLATE SYNTHASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",4,"ARG A 244;ILE A 243;TRP A 238;TYR A 140","None","0.91A","2tsrB-1g38A:undetectable","2tsrB-1g38A:22.08"],["2Y7H_B_SAMB530_0","TYPE I RESTRICTION ENZYME ECOKI M PROTEIN","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"ALA A  47;GLY A  51;ASN A 105;PRO A 107;PHE A 146","NEA A 500 (-3.1A);None;NEA A 500 (-4.5A);NEA A 500 (-3.8A);None","0.98A","2y7hB-1g38A:18.0","2y7hB-1g38A:21.79"],["2Y7H_B_SAMB530_0","TYPE I RESTRICTION ENZYME ECOKI M PROTEIN","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",6,"THR A  23;ALA A  47;LEU A  91;ASN A 105;PRO A 107;PHE A 146","None;NEA A 500 (-3.1A);NEA A 500 ( 4.9A);NEA A 500 (-4.5A);NEA A 500 (-3.8A);None","0.84A","2y7hB-1g38A:18.0","2y7hB-1g38A:21.79"],["2Y7H_C_SAMC530_0","TYPE I RESTRICTION ENZYME ECOKI M PROTEIN","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"ALA A  47;GLY A  51;ASN A 105;PRO A 107;PHE A 146","NEA A 500 (-3.1A);None;NEA A 500 (-4.5A);NEA A 500 (-3.8A);None","0.98A","2y7hC-1g38A:16.1","2y7hC-1g38A:21.79"],["2Y7H_C_SAMC530_0","TYPE I RESTRICTION ENZYME ECOKI M PROTEIN","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",6,"THR A  23;ALA A  47;LEU A  91;ASN A 105;PRO A 107;PHE A 146","None;NEA A 500 (-3.1A);NEA A 500 ( 4.9A);NEA A 500 (-4.5A);NEA A 500 (-3.8A);None","0.84A","2y7hC-1g38A:16.1","2y7hC-1g38A:21.79"],["3AOC_C_ERYC3402_1","ACRIFLAVINE RESISTANCE PROTEIN B","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",3,"THR A 294;SER A 272;LYS A 276","None","1.07A","3aocC-1g38A:0.0","3aocC-1g38A:17.96"],["3CL9_A_MTXA602_2","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",4,"VAL A 341;ARG A 402;ILE A 266;THR A 339","None","1.02A","3cl9A-1g38A:0.8","3cl9A-1g38A:21.50"],["3GRV_A_ADNA300_1","DIMETHYLADENOSINE TRANSFERASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"GLU A  71;ILE A  72;ASP A  73;ASP A  89;PRO A 107","NEA A 500 (-2.8A);NEA A 500 (-3.8A);None;NEA A 500 (-3.4A);NEA A 500 (-3.8A)","0.48A","3grvA-1g38A:7.6","3grvA-1g38A:23.81"],["3GRY_A_SAMA300_0","DIMETHYLADENOSINE TRANSFERASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",7,"GLU A  45;GLU A  71;ILE A  72;ASP A  73;ASP A  89;ASN A 105;PRO A 107","None;NEA A 500 (-2.8A);NEA A 500 (-3.8A);None;NEA A 500 (-3.4A);NEA A 500 (-4.5A);NEA A 500 (-3.8A)","0.61A","3gryA-1g38A:14.3","3gryA-1g38A:23.81"],["3JUS_B_ECNB602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"TYR A 190;THR A 220;PHE A 245;GLY A 193;ALA A 203","None","1.36A","3jusB-1g38A:0.0","3jusB-1g38A:23.85"],["3N8X_B_NIMB1701_2","PROSTAGLANDIN G\/H SYNTHASE 1","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",3,"VAL A 170;VAL A 204;SER A 202","None","0.68A","3n8xB-1g38A:0.0","3n8xB-1g38A:23.56"],["4A79_B_P1BB601_1","AMINE OXIDASE [FLAVIN-CONTAINING] B","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"LEU A 215;ILE A 206;ILE A 243;PHE A 174;TYR A 140","None","1.45A","4a79B-1g38A:1.5","4a79B-1g38A:21.82"],["4GC9_A_SAMA401_1","DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",3,"GLU A  71;ASP A  73;ASP A  89","NEA A 500 (-2.8A);None;NEA A 500 (-3.4A)","0.33A","4gc9A-1g38A:10.8","4gc9A-1g38A:23.83"],["4QVV_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",4,"LYS A 186;GLY A 157;GLY A 158;VAL A 159","None","0.74A","4qvvK-1g38A:undetectable;4qvvL-1g38A:undetectable","4qvvK-1g38A:19.40;4qvvL-1g38A:20.80"],["4QVV_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",4,"LYS A 186;GLY A 157;GLY A 158;VAL A 159","None","0.74A","4qvvY-1g38A:undetectable;4qvvZ-1g38A:undetectable","4qvvY-1g38A:19.40;4qvvZ-1g38A:20.80"],["5FXT_A_0LAA1376_1","DNA POLYMERASE III SUBUNIT BETA","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",4,"LYS A 149;LEU A 153;PRO A  95;ILE A  86","None","1.03A","5fxtA-1g38A:undetectable","5fxtA-1g38A:23.13"],["5JGL_A_SAMA301_0","UBIE\/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"THR A 413;LEU A 358;LEU A 375;PHE A 411;GLY A 410","None","1.34A","5jglA-1g38A:13.1","5jglA-1g38A:20.41"],["5X1B_P_CHDP305_0","CYTOCHROME C OXIDASE SUBUNIT 3","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",4,"LEU A 147;PHE A 146;PHE A 162;LEU A 160","None","1.12A","5x1bP-1g38A:undetectable","5x1bP-1g38A:18.84"],["5X7P_A_ACRA1481_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",4,"SER A 370;ARG A 406;GLU A 408;TYR A 409","None","1.49A","5x7pA-1g38A:0.0","5x7pA-1g38A:14.54"],["5X7P_B_ACRB1481_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",4,"SER A 370;ARG A 406;GLU A 408;TYR A 409","None","1.50A","5x7pB-1g38A:0.0","5x7pB-1g38A:14.54"],["5X7Q_A_ACRA1481_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",4,"SER A 370;ARG A 406;GLU A 408;TYR A 409","None","1.49A","5x7qA-1g38A:0.0","5x7qA-1g38A:14.54"],["5X7R_A_ACRA1481_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",4,"SER A 370;ARG A 406;GLU A 408;TYR A 409","None","1.49A","5x7rA-1g38A:0.0","5x7rA-1g38A:14.54"],["5X7R_B_ACRB1481_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",4,"SER A 370;ARG A 406;GLU A 408;TYR A 409","None","1.47A","5x7rB-1g38A:0.0","5x7rB-1g38A:14.54"],["5YBB_B_SAMB601_0","TYPE I RESTRICTION-MODIFICATION SYSTEM METHYLTRANSFERASE SUBUNIT","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"THR A  23;LEU A  91;ASN A 105;PRO A 107;PHE A 146","None;NEA A 500 ( 4.9A);NEA A 500 (-4.5A);NEA A 500 (-3.8A);None","0.68A","5ybbB-1g38A:18.7","5ybbB-1g38A:23.09"],["5YF9_X_NIOX401_1","CASEIN KINASE II SUBUNIT ALPHA'","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"LEU A 375;VAL A 341;VAL A 333;ILE A 266;PHE A 356","None","0.89A","5yf9X-1g38A:undetectable","5yf9X-1g38A:11.24"],["6EXI_D_ADND502_1","ADENOSYLHOMOCYSTEINASE","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",3,"LEU A 358;ASN A 376;LEU A 298","None","0.70A","6exiD-1g38A:4.7","6exiD-1g38A:13.48"],["6GNF_A_QPSA602_1","-","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"VAL A 121;ASP A  89;PHE A  90;PRO A 107;GLY A 109","None;NEA A 500 (-3.4A);None;NEA A 500 (-3.8A);None","1.46A","6gnfA-1g38A:undetectable","6gnfA-1g38A:22.46"],["6GNF_C_QPSC602_2","-","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",5,"VAL A 121;ASP A  89;GLU A 148;PRO A 107;GLY A 109","None;NEA A 500 (-3.4A);None;NEA A 500 (-3.8A);None","1.41A","6gnfC-1g38A:undetectable","6gnfC-1g38A:22.46"],["6NJ9_K_SAMK500_1","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","1g38","MODIFICATION METHYLASE TAQI","Thermus aquaticus",3,"THR A  23;GLU A  71;ASN A 105","None;NEA A 500 (-2.8A);NEA A 500 (-4.5A)","0.82A","6nj9K-1g38A:10.2","6nj9K-1g38A:23.18"]]