SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g3r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		4 / 7 THR A  18
ASN A  22
GLY A 222
ASP A 200
 ACP  A 238 (-3.7A)
None
None
None
 0.94A 1bu5A-1g3rA:
5.3		 1bu5A-1g3rA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		5 / 8 THR A  18
ASN A  22
ASP A 179
GLY A 222
ASP A 200
 ACP  A 238 (-3.7A)
None
None
None
None
 1.05A 1bu5B-1g3rA:
5.3		 1bu5B-1g3rA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		5 / 10 LEU A 116
ILE A   5
LEU A 194
GLU A 232
LEU A 229
 None
 1.05A 1cqpA-1g3rA:
2.5
1cqpB-1g3rA:
undetectable		 1cqpA-1g3rA:
23.63
1cqpB-1g3rA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		5 / 11 SER A 133
ILE A 115
LEU A  35
LEU A  59
LEU A  84
 None
 1.09A 2a15A-1g3rA:
0.0		 2a15A-1g3rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		5 / 9 ALA A 130
VAL A   8
GLY A 134
ILE A   4
THR A  20
 None
 1.16A 3el4B-1g3rA:
undetectable		 3el4B-1g3rA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		4 / 7 PHE A 114
VAL A  34
ASN A  80
GLY A  28
 None
 1.01A 3kmoB-1g3rA:
undetectable		 3kmoB-1g3rA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		5 / 9 ALA A 130
VAL A   8
GLY A 134
ILE A   4
THR A  20
 None
 1.15A 3spkA-1g3rA:
undetectable		 3spkA-1g3rA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		5 / 12 ALA A 130
VAL A   8
GLY A 134
ILE A   4
THR A  20
 None
 1.01A 3spkB-1g3rA:
undetectable		 3spkB-1g3rA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		5 / 12 LEU A  23
SER A  24
ILE A 197
VAL A 140
VAL A 169
 None
None
ACP  A 238 (-4.8A)
None
None
 1.08A 5dpdB-1g3rA:
undetectable		 5dpdB-1g3rA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		4 / 8 GLY A  15
PHE A 114
ASN A  45
ASP A 118
 ACP  A 238 (-3.0A)
None
None
MG  A 239 ( 4.1A)
 0.90A 5hieD-1g3rA:
0.0		 5hieD-1g3rA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		5 / 12 ILE A 165
GLY A 155
LEU A 194
LEU A 229
LEU A 138
 None
 1.05A 5nfjC-1g3rA:
2.4		 5nfjC-1g3rA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		4 / 7 ALA A  64
LYS A  95
GLU A  91
LEU A  41
 None
 1.03A 6ci6A-1g3rA:
undetectable		 6ci6A-1g3rA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		4 / 4 LEU A 125
ASP A  97
PRO A  98
ARG A  99
 None
 0.73A 6fgdA-1g3rA:
1.2		 6fgdA-1g3rA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 1g3r CELL DIVISION
INHIBITOR
(Pyrococcus
furiosus) 		4 / 5 GLN A  77
THR A  76
THR A  20
GLY A 210
 None
 1.00A 6gbnC-1g3rA:
2.8		 6gbnC-1g3rA:
20.05