SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1g43 SCAFFOLDING PROTEIN
([Clostridium]
cellulolyticum) 		5 / 12 ALA A  24
LEU A  43
VAL A  97
ILE A 112
LEU A  99
 None
 0.97A 2qk8A-1g43A:
undetectable		 2qk8A-1g43A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1g43 SCAFFOLDING PROTEIN
([Clostridium]
cellulolyticum) 		5 / 12 ALA A  24
LEU A  43
VAL A  97
ILE A 112
LEU A  99
 None
 1.12A 3fl9B-1g43A:
undetectable		 3fl9B-1g43A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1g43 SCAFFOLDING PROTEIN
([Clostridium]
cellulolyticum) 		4 / 5 SER A 111
THR A  29
GLU A 113
ASP A  60
 None
 1.43A 3tm4A-1g43A:
undetectable		 3tm4A-1g43A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1g43 SCAFFOLDING PROTEIN
([Clostridium]
cellulolyticum) 		4 / 5 SER A 111
THR A  29
GLU A 113
ASP A  60
 None
 1.43A 3tm4B-1g43A:
undetectable		 3tm4B-1g43A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1g43 SCAFFOLDING PROTEIN
([Clostridium]
cellulolyticum) 		5 / 10 ALA A  98
PHE A  26
VAL A  28
ILE A 146
ALA A 155
 None
 1.11A 4j14A-1g43A:
undetectable		 4j14A-1g43A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1g43 SCAFFOLDING PROTEIN
([Clostridium]
cellulolyticum) 		4 / 7 ASN A  30
VAL A   6
ALA A 155
GLY A 151
 None
 0.82A 5fpdB-1g43A:
undetectable		 5fpdB-1g43A:
16.40