SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		5 / 8 LEU S 183
LEU S 186
ALA S 277
LYS S 278
LYS S 281
 None
 1.39A 1e7cA-1g4uS:
2.7		 1e7cA-1g4uS:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		5 / 11 LEU S 218
ALA S 175
VAL S 231
LEU S 234
LEU S 280
 None
 1.16A 1rlbF-1g4uS:
1.0		 1rlbF-1g4uS:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		5 / 12 LEU S 218
LEU S 227
ASN S 228
LEU S 280
LEU S 234
 None
 1.12A 1sqnB-1g4uS:
undetectable		 1sqnB-1g4uS:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		4 / 7 GLY S 347
ILE S 317
THR S 304
ARG S 516
 None
 0.77A 2xrhA-1g4uS:
undetectable		 2xrhA-1g4uS:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		4 / 5 ILE S 415
ARG S 487
MET S 491
THR S 488
 None
 1.30A 3abkN-1g4uS:
0.2
3abkW-1g4uS:
0.0		 3abkN-1g4uS:
20.94
3abkW-1g4uS:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		4 / 5 LYS S 362
ASP S 327
GLU S 398
GLU S 366
 None
 1.43A 3dh0B-1g4uS:
0.3		 3dh0B-1g4uS:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		4 / 6 ARG S 516
SER S 348
GLY S 302
GLU S 286
 None
 1.06A 3k9fA-1g4uS:
0.0
3k9fB-1g4uS:
0.0
3k9fD-1g4uS:
2.2		 3k9fA-1g4uS:
21.92
3k9fB-1g4uS:
21.92
3k9fD-1g4uS:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		5 / 9 ARG S 516
GLY S 484
GLY S 483
PHE S 310
GLY S 347
 None
 1.46A 4h2gA-1g4uS:
undetectable		 4h2gA-1g4uS:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		5 / 12 MET S 533
LEU S 497
LEU S 375
LEU S 451
MET S 478
 None
 1.42A 4m11A-1g4uS:
0.0		 4m11A-1g4uS:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		5 / 10 LEU S 218
LEU S 215
ALA S 175
LEU S 183
LEU S 287
 None
 1.28A 4p65A-1g4uS:
undetectable
4p65B-1g4uS:
undetectable
4p65F-1g4uS:
undetectable
4p65H-1g4uS:
undetectable		 4p65A-1g4uS:
5.00
4p65B-1g4uS:
6.65
4p65F-1g4uS:
6.65
4p65H-1g4uS:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		5 / 12 LEU S 357
ASN S 402
THR S 430
VAL S 399
HIS S 480
 None
 1.25A 5d0yA-1g4uS:
0.8		 5d0yA-1g4uS:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		5 / 12 LEU S 357
ASN S 402
THR S 430
VAL S 399
HIS S 480
 None
 1.25A 5d0yB-1g4uS:
0.7		 5d0yB-1g4uS:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP
(Salmonella
enterica) 		5 / 12 ILE S 315
THR S 304
GLU S 279
ASN S 282
ILE S 317
 None
 1.18A 5lg3J-1g4uS:
0.0		 5lg3J-1g4uS:
20.60