SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g55'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 8 PHE A  70
ILE A  73
PHE A 142
LEU A 109
 None
 0.88A 1fslA-1g55A:
undetectable		 1fslA-1g55A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 8 PHE A  70
ILE A  73
PHE A 142
LEU A 109
 None
 0.82A 1fslB-1g55A:
undetectable		 1fslB-1g55A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 4 LEU A 112
PRO A 113
LEU A 106
ARG A 108
 None
None
None
SO4  A 399 (-2.8A)
 1.39A 1hrkB-1g55A:
3.0		 1hrkB-1g55A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 8 GLY A  14
GLY A  15
MET A  16
SER A  76
 SAH  A 392 ( 4.2A)
SAH  A 392 (-3.1A)
None
SAH  A 392 (-3.2A)
 0.59A 1qzzA-1g55A:
9.0		 1qzzA-1g55A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		5 / 12 GLY A  12
GLY A  15
MET A  16
VAL A  35
ILE A  57
 SAH  A 392 (-3.4A)
SAH  A 392 (-3.1A)
None
SAH  A 392 (-3.9A)
SAH  A 392 (-4.1A)
 0.73A 2b25A-1g55A:
8.6		 2b25A-1g55A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		5 / 12 GLY A  12
GLY A  15
MET A  16
VAL A  35
ILE A  57
 SAH  A 392 (-3.4A)
SAH  A 392 (-3.1A)
None
SAH  A 392 (-3.9A)
SAH  A 392 (-4.1A)
 0.71A 2b25B-1g55A:
7.7		 2b25B-1g55A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 4 LEU A 112
PRO A 113
LEU A 106
ARG A 108
 None
None
None
SO4  A 399 (-2.8A)
 1.39A 2hrcB-1g55A:
0.6		 2hrcB-1g55A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 4 LEU A 112
PRO A 113
LEU A 106
ARG A 108
 None
None
None
SO4  A 399 (-2.8A)
 1.38A 2pnjB-1g55A:
1.1		 2pnjB-1g55A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		3 / 3 MET A 184
GLU A 146
ASP A 131
 None
 1.05A 3a25A-1g55A:
8.9		 3a25A-1g55A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 7 PHE A 360
GLU A  41
VAL A  38
VAL A  13
 None
None
None
SAH  A 392 (-3.8A)
 1.29A 3dqrA-1g55A:
0.0
3dqrB-1g55A:
0.0		 3dqrA-1g55A:
21.49
3dqrB-1g55A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 7 PHE A 360
GLU A  41
VAL A  38
VAL A  13
 None
None
None
SAH  A 392 (-3.8A)
 1.32A 3jx4A-1g55A:
0.1
3jx4B-1g55A:
0.0		 3jx4A-1g55A:
21.49
3jx4B-1g55A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 7 PHE A 360
GLU A  41
VAL A  38
VAL A  13
 None
None
None
SAH  A 392 (-3.8A)
 1.31A 3jx5A-1g55A:
0.0
3jx5B-1g55A:
0.0		 3jx5A-1g55A:
21.49
3jx5B-1g55A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 6 VAL A  38
VAL A  13
PHE A 360
GLU A  41
 None
SAH  A 392 (-3.8A)
None
None
 1.33A 3n61A-1g55A:
0.2
3n61B-1g55A:
0.0		 3n61A-1g55A:
21.49
3n61B-1g55A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		5 / 11 LEU A 351
ASN A 158
ARG A 160
LEU A 253
LEU A 257
 None
None
None
CSO  A 287 ( 3.7A)
None
 1.36A 3ndvA-1g55A:
0.0
3ndvB-1g55A:
0.0		 3ndvA-1g55A:
22.91
3ndvB-1g55A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		5 / 11 LEU A 351
ASN A 158
ARG A 160
LEU A 253
LEU A 257
 None
None
None
CSO  A 287 ( 3.7A)
None
 1.37A 3ndvC-1g55A:
0.0
3ndvD-1g55A:
0.0		 3ndvC-1g55A:
22.91
3ndvD-1g55A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		5 / 11 LEU A 253
LEU A 257
LEU A 351
ASN A 158
ARG A 160
 CSO  A 287 ( 3.7A)
None
None
None
None
 1.35A 3ndvC-1g55A:
undetectable
3ndvD-1g55A:
0.0		 3ndvC-1g55A:
22.91
3ndvD-1g55A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 7 PHE A 360
GLU A  41
VAL A  38
VAL A  13
 None
None
None
SAH  A 392 (-3.8A)
 1.30A 3nljA-1g55A:
0.0
3nljB-1g55A:
0.0		 3nljA-1g55A:
21.49
3nljB-1g55A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 7 PHE A 360
GLU A  41
VAL A  38
VAL A  13
 None
None
None
SAH  A 392 (-3.8A)
 1.32A 3nlpA-1g55A:
0.0
3nlpB-1g55A:
0.0		 3nlpA-1g55A:
21.49
3nlpB-1g55A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		3 / 3 PHE A 293
TYR A 342
TYR A 370
 None
 1.05A 4ffwA-1g55A:
2.3		 4ffwA-1g55A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 6 TYR A 144
TYR A 163
LEU A 118
PHE A 124
 None
 1.35A 4twdF-1g55A:
0.0
4twdG-1g55A:
0.0		 4twdF-1g55A:
21.29
4twdG-1g55A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 7 PHE A 360
GLU A  41
VAL A  38
VAL A  13
 None
None
None
SAH  A 392 (-3.8A)
 1.31A 5adeA-1g55A:
0.0
5adeB-1g55A:
0.0		 5adeA-1g55A:
21.49
5adeB-1g55A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 7 PHE A 360
GLU A  41
VAL A  38
VAL A  13
 None
None
None
SAH  A 392 (-3.8A)
 1.32A 5g0pA-1g55A:
0.0
5g0pB-1g55A:
0.0		 5g0pA-1g55A:
21.49
5g0pB-1g55A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 5 LEU A 385
LEU A  74
PHE A 164
LEU A 377
 None
None
None
SAH  A 392 ( 4.7A)
 1.01A 5gtrA-1g55A:
0.0		 5gtrA-1g55A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		5 / 8 ALA A 167
LEU A 106
LEU A 118
MET A  75
LEU A 133
 None
 1.26A 5jqbA-1g55A:
undetectable
5jqbB-1g55A:
undetectable		 5jqbA-1g55A:
22.72
5jqbB-1g55A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 6 ILE A 156
ILE A 386
LEU A 385
PHE A 186
 None
 1.05A 5vkqA-1g55A:
0.0
5vkqB-1g55A:
0.0		 5vkqA-1g55A:
12.21
5vkqB-1g55A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 6 ILE A 156
ILE A 386
LEU A 385
PHE A 186
 None
 1.03A 5vkqB-1g55A:
0.0
5vkqC-1g55A:
0.0		 5vkqB-1g55A:
12.21
5vkqC-1g55A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 6 ILE A 156
ILE A 386
LEU A 385
PHE A 186
 None
 1.02A 5vkqC-1g55A:
0.0
5vkqD-1g55A:
0.0		 5vkqC-1g55A:
12.21
5vkqD-1g55A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 6 ILE A 156
ILE A 386
LEU A 385
PHE A 186
 None
 1.03A 5vkqA-1g55A:
0.0
5vkqD-1g55A:
0.0		 5vkqA-1g55A:
12.21
5vkqD-1g55A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		4 / 6 LEU A 373
VAL A 250
PHE A 358
GLY A  15
 None
None
None
SAH  A 392 (-3.1A)
 0.90A 6hd4B-1g55A:
undetectable		 6hd4B-1g55A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		5 / 12 GLY A  12
GLY A  15
ILE A  57
ASN A 375
SER A 376
 SAH  A 392 (-3.4A)
SAH  A 392 (-3.1A)
SAH  A 392 (-4.1A)
SAH  A 392 (-4.7A)
SAH  A 392 (-2.9A)
 0.62A 6mhtA-1g55A:
25.1		 6mhtA-1g55A:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		5 / 12 PHE A  65
ILE A  73
LEU A 389
LEU A 112
PHE A  70
 None
 1.18A 6r2eE-1g55A:
0.0		 6r2eE-1g55A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens) 		5 / 11 PHE A  65
ILE A  73
LEU A 389
LEU A 112
PHE A  70
 None
 1.19A 6r2eG-1g55A:
0.0		 6r2eG-1g55A:
21.25