SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 PHE A 289
GLU A 287
ILE A 290
LEU A  65
GLY A  64
 None
 1.48A 1i00A-1g59A:
0.0		 1i00A-1g59A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 LEU A 427
VAL A 430
LEU A 434
 C  B 534 ( 3.6A)
None
None
 0.38A 1mz9B-1g59A:
undetectable		 1mz9B-1g59A:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LYS A 149
LEU A 148
LEU A 219
PHE A 223
 None
 1.02A 1v55C-1g59A:
undetectable
1v55J-1g59A:
0.0		 1v55C-1g59A:
18.76
1v55J-1g59A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LYS A 149
LEU A 148
LEU A 219
PHE A 223
 None
 0.97A 1v55P-1g59A:
undetectable
1v55W-1g59A:
0.0		 1v55P-1g59A:
18.76
1v55W-1g59A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LYS A 149
LEU A 148
LEU A 219
PHE A 223
 None
 0.90A 2dysC-1g59A:
0.0
2dysJ-1g59A:
0.0		 2dysC-1g59A:
18.76
2dysJ-1g59A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LYS A 149
LEU A 148
LEU A 219
PHE A 223
 None
 0.99A 2dysP-1g59A:
undetectable
2dysW-1g59A:
0.0		 2dysP-1g59A:
18.76
2dysW-1g59A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LYS A 149
LEU A 148
LEU A 219
PHE A 223
 None
 0.97A 2eijC-1g59A:
undetectable
2eijJ-1g59A:
0.0		 2eijC-1g59A:
18.76
2eijJ-1g59A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LYS A 149
LEU A 148
LEU A 219
PHE A 223
 None
 0.92A 2eimP-1g59A:
undetectable
2eimW-1g59A:
0.0		 2eimP-1g59A:
18.76
2eimW-1g59A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LYS A 149
LEU A 148
LEU A 219
PHE A 223
 None
 0.98A 2einC-1g59A:
0.0
2einJ-1g59A:
0.0		 2einC-1g59A:
18.76
2einJ-1g59A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 GLY A 124
ARG A 127
TYR A 122
 None
 0.75A 2opxA-1g59A:
2.8		 2opxA-1g59A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 PHE A 289
GLU A 287
ILE A 290
LEU A  65
GLY A  64
 None
 1.45A 2tsrC-1g59A:
0.0		 2tsrC-1g59A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 LEU A 340
LEU A 348
ALA A 351
PHE A 365
 None
 0.77A 2vcvF-1g59A:
undetectable		 2vcvF-1g59A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LYS A 149
LEU A 148
LEU A 219
PHE A 223
 None
 0.97A 2zxwC-1g59A:
undetectable
2zxwJ-1g59A:
0.0		 2zxwC-1g59A:
18.76
2zxwJ-1g59A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 TYR A  67
ALA A   7
ALA A  19
TYR A  20
 None
 1.24A 3d91A-1g59A:
0.0		 3d91A-1g59A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 PHE A 373
GLY A 455
MET A 355
PHE A 365
 None
 1.12A 3ko0K-1g59A:
0.0
3ko0S-1g59A:
0.0		 3ko0K-1g59A:
12.15
3ko0S-1g59A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 ASN A 238
ASP A 306
GLU A 282
SER A 249
 None
None
A  B 524 ( 3.2A)
None
 1.38A 3p2kC-1g59A:
undetectable		 3p2kC-1g59A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LEU A  60
LEU A  57
PRO A  10
ILE A  56
 None
 0.95A 3s56B-1g59A:
undetectable		 3s56B-1g59A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 PHE A 293
PHE A 289
ALA A  29
THR A   4
ILE A 204
 None
 1.48A 3t3qC-1g59A:
0.0		 3t3qC-1g59A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 PHE A 289
PHE A 284
PHE A  24
GLY A 274
PHE A 293
 None
None
None
U  B 513 ( 3.3A)
None
 1.12A 3t3rA-1g59A:
0.0		 3t3rA-1g59A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 PHE A 289
PHE A 284
PHE A  24
GLY A 274
PHE A 293
 None
None
None
U  B 513 ( 3.3A)
None
 1.18A 3t3rB-1g59A:
0.0		 3t3rB-1g59A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 PHE A 289
PHE A 284
PHE A  24
GLY A 274
PHE A 293
 None
None
None
U  B 513 ( 3.3A)
None
 1.19A 3t3rC-1g59A:
0.0		 3t3rC-1g59A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 PHE A 289
PHE A 284
PHE A  24
GLY A 274
PHE A 293
 None
None
None
U  B 513 ( 3.3A)
None
 1.22A 3t3rD-1g59A:
0.0		 3t3rD-1g59A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 4 VAL A 217
VAL A 158
ASN A 170
ILE A 173
 None
 1.07A 4cutA-1g59A:
undetectable		 4cutA-1g59A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 ASN A 268
ALA A 265
PRO A 263
LEU A 310
 None
 0.92A 4jjkA-1g59A:
undetectable		 4jjkA-1g59A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 ARG A 385
LYS A 386
LYS A 382
 None
 0.94A 4k50A-1g59A:
0.0		 4k50A-1g59A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 ARG A 385
LYS A 386
LYS A 382
 None
 0.82A 4k50E-1g59A:
0.0		 4k50E-1g59A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 ARG A 385
LYS A 386
LYS A 382
 None
 0.85A 4k50I-1g59A:
0.0		 4k50I-1g59A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 ALA A 452
LEU A 451
LEU A 401
LEU A 415
LEU A 416
 None
 0.94A 4wg0C-1g59A:
undetectable
4wg0D-1g59A:
undetectable
4wg0E-1g59A:
undetectable		 4wg0C-1g59A:
2.18
4wg0D-1g59A:
2.18
4wg0E-1g59A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 ALA A 452
LEU A 451
LEU A 401
LEU A 415
LEU A 416
 None
 0.94A 4wg0E-1g59A:
undetectable
4wg0F-1g59A:
undetectable
4wg0G-1g59A:
undetectable		 4wg0E-1g59A:
2.18
4wg0F-1g59A:
2.18
4wg0G-1g59A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 LEU A 401
GLU A 409
LEU A 451
ALA A 414
LEU A 416
 None
 1.13A 4wg0H-1g59A:
undetectable
4wg0I-1g59A:
undetectable
4wg0J-1g59A:
undetectable		 4wg0H-1g59A:
2.18
4wg0I-1g59A:
2.18
4wg0J-1g59A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 ALA A 414
LEU A 416
GLU A 409
LEU A 451
LEU A 401
 None
 1.10A 4wg0K-1g59A:
undetectable
4wg0L-1g59A:
undetectable
4wg0M-1g59A:
undetectable		 4wg0K-1g59A:
2.18
4wg0L-1g59A:
2.18
4wg0M-1g59A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 VAL A 352
LEU A 324
SER A 323
GLU A 326
 None
 0.99A 4zphA-1g59A:
0.0
4zphB-1g59A:
0.0		 4zphA-1g59A:
20.53
4zphB-1g59A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 LEU A  65
ILE A  56
GLY A  17
LEU A 266
 None
 0.89A 5eseA-1g59A:
undetectable		 5eseA-1g59A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1g59 GLUTAMYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 LYS A 149
LEU A 148
LEU A 219
PHE A 223
 None
 0.99A 5w97C-1g59A:
0.0
5w97J-1g59A:
0.0		 5w97C-1g59A:
18.76
5w97J-1g59A:
12.26