SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 GLN A  78
TYR A   3
ARG A   2
 None
 0.83A 1gtbA-1g5bA:
undetectable		 1gtbA-1g5bA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		5 / 11 LEU A  50
VAL A  18
GLY A  19
LEU A  63
GLU A  77
 None
 1.46A 1jkhA-1g5bA:
undetectable
1jkhB-1g5bA:
undetectable		 1jkhA-1g5bA:
16.55
1jkhB-1g5bA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ARG A 162
ILE A 159
TRP A 160
 SO4  A3001 (-3.3A)
None
None
 0.85A 1m8eB-1g5bA:
0.0		 1m8eB-1g5bA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ARG A 162
ILE A 159
TRP A 160
 SO4  A3001 (-3.3A)
None
None
 0.93A 1nodB-1g5bA:
undetectable		 1nodB-1g5bA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ASP A  49
HIS A  76
HIS A  22
 MN  A1005 (-2.6A)
SO4  A3001 (-3.9A)
MN  A1006 (-3.4A)
 0.63A 1oe1A-1g5bA:
undetectable		 1oe1A-1g5bA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ASP A  49
HIS A  76
HIS A  22
 MN  A1005 (-2.6A)
SO4  A3001 (-3.9A)
MN  A1006 (-3.4A)
 0.61A 1oe3A-1g5bA:
undetectable		 1oe3A-1g5bA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ARG A 162
ILE A 159
TRP A 160
 SO4  A3001 (-3.3A)
None
None
 0.90A 1qomA-1g5bA:
undetectable		 1qomA-1g5bA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ARG A 162
ILE A 159
TRP A 160
 SO4  A3001 (-3.3A)
None
None
 0.95A 2nodB-1g5bA:
undetectable		 2nodB-1g5bA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		5 / 12 ILE A 214
LEU A  28
VAL A  47
PHE A  69
LEU A  43
 None
 1.21A 2qo5A-1g5bA:
0.0		 2qo5A-1g5bA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ASP A  49
HIS A  76
HIS A  22
 MN  A1005 (-2.6A)
SO4  A3001 (-3.9A)
MN  A1006 (-3.4A)
 0.65A 2xxgA-1g5bA:
undetectable		 2xxgA-1g5bA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ASP A  49
HIS A  76
HIS A  22
 MN  A1005 (-2.6A)
SO4  A3001 (-3.9A)
MN  A1006 (-3.4A)
 0.66A 2xxgC-1g5bA:
undetectable		 2xxgC-1g5bA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		5 / 12 GLY A  99
LEU A 104
ILE A  81
ASN A  57
LEU A  61
 None
 1.12A 2zbpA-1g5bA:
undetectable		 2zbpA-1g5bA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ARG A 162
ILE A 159
TRP A 160
 SO4  A3001 (-3.3A)
None
None
 0.95A 3e68A-1g5bA:
0.0		 3e68A-1g5bA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ARG A 162
ILE A 159
TRP A 160
 SO4  A3001 (-3.3A)
None
None
 0.87A 3e6tB-1g5bA:
0.0		 3e6tB-1g5bA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ARG A 162
ILE A 159
TRP A 160
 SO4  A3001 (-3.3A)
None
None
 0.91A 3e7iB-1g5bA:
undetectable		 3e7iB-1g5bA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ARG A 162
ILE A 159
TRP A 160
 SO4  A3001 (-3.3A)
None
None
 0.94A 3nw2A-1g5bA:
undetectable		 3nw2A-1g5bA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 ARG A 162
ILE A 159
TRP A 160
 SO4  A3001 (-3.3A)
None
None
 0.95A 3nw2B-1g5bA:
undetectable		 3nw2B-1g5bA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		5 / 12 ALA A 205
GLY A  23
HIS A  22
ASN A  27
LEU A  44
 None
None
MN  A1006 (-3.4A)
None
None
 1.12A 3tm4A-1g5bA:
undetectable		 3tm4A-1g5bA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		5 / 12 ALA A 205
GLY A  23
HIS A  22
ASN A  27
LEU A  44
 None
None
MN  A1006 (-3.4A)
None
None
 1.17A 3tm4B-1g5bA:
undetectable		 3tm4B-1g5bA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		4 / 5 ILE A 125
ILE A 176
TYR A 147
GLU A 146
 None
 1.14A 4a99D-1g5bA:
undetectable		 4a99D-1g5bA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		3 / 3 LEU A  44
ARG A  70
MET A   1
 None
 0.91A 4m11C-1g5bA:
undetectable		 4m11C-1g5bA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		4 / 8 ILE A 125
LEU A  44
LEU A 128
ILE A  15
 None
 0.88A 4r38D-1g5bA:
undetectable		 4r38D-1g5bA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		4 / 6 ASP A  20
HIS A 139
ILE A 183
TYR A 200
 MN  A1006 (-3.4A)
MN  A1005 (-3.4A)
None
None
 1.24A 5ih0A-1g5bA:
0.0		 5ih0A-1g5bA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		4 / 4 ASP A  49
HIS A 139
HIS A 186
HIS A  76
 MN  A1005 (-2.6A)
MN  A1005 (-3.4A)
MN  A1005 ( 3.3A)
SO4  A3001 (-3.9A)
 1.49A 5ncdD-1g5bA:
undetectable		 5ncdD-1g5bA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		5 / 12 LEU A  21
LEU A  50
GLY A  48
VAL A  72
LEU A  44
 None
 1.10A 5uc1A-1g5bA:
undetectable		 5uc1A-1g5bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		5 / 12 LEU A  21
LEU A  50
GLY A  48
VAL A  72
LEU A  44
 None
 1.12A 5uc1B-1g5bA:
undetectable		 5uc1B-1g5bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE
(Escherichia
virus
Lambda) 		5 / 12 ALA A 112
LEU A 115
VAL A  51
GLY A  23
THR A  26
 None
 1.15A 5x24A-1g5bA:
0.1		 5x24A-1g5bA:
17.02