SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 8 CYH A  32
ASP A  34
HIS A  87
CYH A  90
GLY A  91
 ZN  A1001 (-2.4A)
EPE  A2201 (-3.3A)
ZN  A1001 (-3.2A)
ZN  A1001 ( 2.3A)
None
 0.77A 1ekjA-1g5cA:
13.4
1ekjB-1g5cA:
13.1		 1ekjA-1g5cA:
24.07
1ekjB-1g5cA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 8 CYH A  32
ASP A  34
HIS A  87
CYH A  90
GLY A  91
 ZN  A1001 (-2.4A)
EPE  A2201 (-3.3A)
ZN  A1001 (-3.2A)
ZN  A1001 ( 2.3A)
None
 0.70A 1ekjA-1g5cA:
13.4
1ekjB-1g5cA:
13.1		 1ekjA-1g5cA:
24.07
1ekjB-1g5cA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 CYH A  32
ASP A  34
HIS A  87
GLY A  91
 ZN  A1001 (-2.4A)
EPE  A2201 (-3.3A)
ZN  A1001 (-3.2A)
None
 0.73A 1ekjE-1g5cA:
13.0
1ekjF-1g5cA:
12.7		 1ekjE-1g5cA:
24.07
1ekjF-1g5cA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ASP A  34
HIS A  87
CYH A  90
GLY A  91
 EPE  A2201 (-3.3A)
ZN  A1001 (-3.2A)
ZN  A1001 ( 2.3A)
None
 0.93A 1ekjG-1g5cA:
13.2
1ekjH-1g5cA:
13.3		 1ekjG-1g5cA:
24.07
1ekjH-1g5cA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 8 CYH A  32
ASP A  34
HIS A  87
CYH A  90
GLY A  91
 ZN  A1001 (-2.4A)
EPE  A2201 (-3.3A)
ZN  A1001 (-3.2A)
ZN  A1001 ( 2.3A)
None
 0.72A 1ekjG-1g5cA:
13.2
1ekjH-1g5cA:
13.3		 1ekjG-1g5cA:
24.07
1ekjH-1g5cA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 CYH A  32
ASP A  34
HIS A  87
CYH A  90
 ZN  A1001 (-2.4A)
EPE  A2201 (-3.3A)
ZN  A1001 (-3.2A)
ZN  A1001 ( 2.3A)
 0.21A 1ekjG-1g5cA:
13.2
1ekjH-1g5cA:
13.3		 1ekjG-1g5cA:
24.07
1ekjH-1g5cA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ILE A  67
ILE A 145
VAL A  62
ILE A  82
ILE A  30
 None
 1.14A 3p4wB-1g5cA:
0.0		 3p4wB-1g5cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 ILE A  67
ILE A 145
VAL A  62
ILE A  82
ILE A  30
 None
 1.14A 3p4wD-1g5cA:
0.0		 3p4wD-1g5cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 ILE A  67
ILE A 145
VAL A  62
ILE A  82
ILE A  30
 None
 1.13A 3p4wE-1g5cA:
0.0		 3p4wE-1g5cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 ILE A  47
LEU A  45
VAL A  66
SER A  69
 None
 0.99A 3r9vA-1g5cA:
0.0
3r9vB-1g5cA:
0.0		 3r9vA-1g5cA:
17.77
3r9vB-1g5cA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 CYH A  32
ASP A  34
HIS A  87
CYH A  90
GLY A  91
 ZN  A1001 (-2.4A)
EPE  A2201 (-3.3A)
ZN  A1001 (-3.2A)
ZN  A1001 ( 2.3A)
None
 0.61A 3ucjA-1g5cA:
14.0		 3ucjA-1g5cA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 CYH A  32
ASP A  34
HIS A  87
CYH A  90
GLY A  91
 ZN  A1001 (-2.4A)
EPE  A2201 (-3.3A)
ZN  A1001 (-3.2A)
ZN  A1001 ( 2.3A)
None
 0.59A 3ucjB-1g5cA:
14.4		 3ucjB-1g5cA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1g5c BETA-CARBONIC
ANHYDRASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 PRO A 146
VAL A 151
HIS A 152
 None
 0.80A 4pevC-1g5cA:
4.7		 4pevC-1g5cA:
19.35