SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		4 / 8 LEU A 386
GLY A  41
ILE A  42
ILE A 391
 None
 0.64A 1d4yB-1g5gA:
undetectable		 1d4yB-1g5gA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		5 / 12 LEU A 345
TYR A 302
VAL A 319
VAL A 323
LEU A 363
 None
 0.98A 1vptA-1g5gA:
undetectable		 1vptA-1g5gA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		5 / 12 ILE A  63
ASN A  85
LEU A  88
THR A  89
LEU A  91
 None
NAG  A 851 (-1.8A)
None
NAG  A 851 (-4.1A)
None
 0.75A 2bdmA-1g5gA:
0.0		 2bdmA-1g5gA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		4 / 4 ILE A 285
PHE A 221
ILE A  61
THR A 231
 None
 1.07A 3ia4A-1g5gA:
undetectable		 3ia4A-1g5gA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		3 / 3 TYR A 239
LEU A  65
LYS A  64
 None
 0.77A 3sueD-1g5gA:
0.0		 3sueD-1g5gA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		4 / 4 ASP A 344
THR A 341
VAL A 292
SER A 261
 None
 1.13A 3wxoA-1g5gA:
0.0		 3wxoA-1g5gA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		4 / 8 LEU A 345
SER A 262
SER A 265
SER A 261
 None
 0.98A 4ikkA-1g5gA:
undetectable
4ikkB-1g5gA:
undetectable		 4ikkA-1g5gA:
13.86
4ikkB-1g5gA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		3 / 3 ASN A 294
ASP A 344
ASP A  47
 None
 0.56A 4obwD-1g5gA:
undetectable		 4obwD-1g5gA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		4 / 7 THR A  87
LEU A  88
THR A 218
LEU A 217
 None
 0.90A 4z91F-1g5gA:
0.0
4z91G-1g5gA:
0.0
4z91H-1g5gA:
0.0
4z91I-1g5gA:
0.0
4z91J-1g5gA:
0.0		 4z91F-1g5gA:
21.98
4z91G-1g5gA:
21.98
4z91H-1g5gA:
21.98
4z91I-1g5gA:
21.98
4z91J-1g5gA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		4 / 6 ILE A 235
ALA A 237
LEU A 238
ILE A 269
 None
 0.86A 5mvmB-1g5gA:
undetectable
5mvmC-1g5gA:
undetectable		 5mvmB-1g5gA:
10.04
5mvmC-1g5gA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		4 / 4 LEU A 268
GLY A 267
SER A 265
SER A 262
 None
 1.27A 5uunB-1g5gA:
0.0		 5uunB-1g5gA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		4 / 8 GLN A 224
GLY A 284
ILE A  99
ASP A 277
 None
 0.93A 5vlmH-1g5gA:
undetectable		 5vlmH-1g5gA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1g5g FUSION PROTEIN
(Avian
avulavirus
1) 		3 / 3 ASP A 342
LEU A 343
ARG A 299
 None
 0.68A 7dfrA-1g5gA:
undetectable		 7dfrA-1g5gA:
14.89