SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		3 / 4 VAL A  94
TRP A 236
TRP A  89
 None
 1.27A 1gmkA-1g5iA:
undetectable
1gmkB-1g5iA:
undetectable		 1gmkA-1g5iA:
5.37
1gmkB-1g5iA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		3 / 4 VAL A  94
TRP A 236
TRP A  89
 None
 1.43A 1gmkC-1g5iA:
undetectable
1gmkD-1g5iA:
undetectable		 1gmkC-1g5iA:
5.37
1gmkD-1g5iA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		5 / 10 MET A  92
LEU A 213
ALA A 211
GLU A 210
HIS A 232
 None
 1.38A 2ocfA-1g5iA:
0.0		 2ocfA-1g5iA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		3 / 3 TRP A 225
VAL A 309
TRP A 229
 None
 1.26A 2xdcC-1g5iA:
undetectable
2xdcD-1g5iA:
undetectable		 2xdcC-1g5iA:
5.37
2xdcD-1g5iA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		3 / 3 TRP A 225
VAL A 309
TRP A 229
 None
 1.25A 2xdcE-1g5iA:
undetectable
2xdcF-1g5iA:
undetectable		 2xdcE-1g5iA:
5.37
2xdcF-1g5iA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		3 / 3 TRP A 225
VAL A 309
TRP A 229
 None
 1.22A 2y5mE-1g5iA:
undetectable
2y5mF-1g5iA:
undetectable		 2y5mE-1g5iA:
5.37
2y5mF-1g5iA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		3 / 3 TRP A 225
VAL A 309
TRP A 229
 None
 1.23A 2y6nC-1g5iA:
undetectable
2y6nD-1g5iA:
undetectable		 2y6nC-1g5iA:
5.37
2y6nD-1g5iA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		3 / 3 TRP A 225
VAL A 309
TRP A 229
 None
 1.25A 2y6nE-1g5iA:
undetectable
2y6nF-1g5iA:
undetectable		 2y6nE-1g5iA:
5.37
2y6nF-1g5iA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		4 / 5 ALA A 183
LEU A 159
GLY A 186
THR A 320
 None
 0.94A 3dl9A-1g5iA:
undetectable		 3dl9A-1g5iA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		4 / 7 PHE A  73
VAL A 187
ARG A  72
VAL A 316
 None
 1.32A 3dqrA-1g5iA:
0.2
3dqrB-1g5iA:
0.0		 3dqrA-1g5iA:
22.18
3dqrB-1g5iA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		4 / 6 VAL A 187
ARG A  72
VAL A 316
PHE A  73
 None
 1.36A 3jx4A-1g5iA:
0.1
3jx4B-1g5iA:
0.0		 3jx4A-1g5iA:
22.18
3jx4B-1g5iA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		4 / 7 PHE A  73
VAL A 187
ARG A  72
VAL A 316
 None
 1.29A 3jx4A-1g5iA:
undetectable
3jx4B-1g5iA:
undetectable		 3jx4A-1g5iA:
22.18
3jx4B-1g5iA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		4 / 5 LEU A 321
GLY A 319
PHE A  73
ARG A  72
 None
 0.86A 3smtA-1g5iA:
0.0		 3smtA-1g5iA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		4 / 6 SER A 311
ASP A 254
ARG A 258
GLU A 284
 None
 1.04A 4eysA-1g5iA:
2.4		 4eysA-1g5iA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		5 / 12 THR A 418
LEU A 416
GLY A 390
PRO A 389
ALA A 358
 None
 1.18A 4ypmA-1g5iA:
undetectable		 4ypmA-1g5iA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		4 / 6 VAL A 187
ARG A  72
VAL A 316
PHE A  73
 None
 1.38A 5addA-1g5iA:
0.0
5addB-1g5iA:
0.0		 5addA-1g5iA:
22.18
5addB-1g5iA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		4 / 6 VAL A 187
ARG A  72
VAL A 316
PHE A  73
 None
 1.44A 5adeA-1g5iA:
0.0
5adeB-1g5iA:
0.0		 5adeA-1g5iA:
22.18
5adeB-1g5iA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT
(Mus
musculus) 		3 / 3 VAL A 417
GLN A 371
CYH A 373
 None
 0.70A 5icxA-1g5iA:
1.7
5icxE-1g5iA:
undetectable		 5icxA-1g5iA:
19.78
5icxE-1g5iA:
5.28