SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 11 LEU A1101
ALA A1024
VAL A1032
GLY A1068
ILE A1026
 None
 0.97A 1t3rB-1g5uA:
undetectable		 1t3rB-1g5uA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 9 VAL A1119
LEU A1020
ILE A1105
ILE A1075
GLY A1077
 None
 1.24A 3cv9A-1g5uA:
undetectable		 3cv9A-1g5uA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 9 ILE A1102
GLY A1104
ILE A1105
VAL A1032
ILE A1026
 None
 1.16A 3d1yB-1g5uA:
undetectable		 3d1yB-1g5uA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 9 ILE A1102
GLY A1104
ILE A1105
VAL A1032
ILE A1026
 None
 1.14A 3ekyB-1g5uA:
undetectable		 3ekyB-1g5uA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 9 ILE A1102
GLY A1104
ILE A1105
VAL A1032
ILE A1026
 None
 1.13A 3nuoA-1g5uA:
undetectable		 3nuoA-1g5uA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 12 ALA A1049
ILE A1026
ILE A1103
LEU A1101
VAL A1094
 None
 1.00A 3rukB-1g5uA:
undetectable		 3rukB-1g5uA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 11 LEU A1101
GLU A1046
LEU A1065
PRO A1040
PHE A1039
 None
 1.28A 3ua5A-1g5uA:
0.0		 3ua5A-1g5uA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 9 ILE A1083
ILE A1103
ILE A1102
TYR A1125
ILE A1026
 None
 0.97A 3zosA-1g5uA:
undetectable		 3zosA-1g5uA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 12 ILE A1105
ALA A1024
ILE A1026
LEU A1065
ILE A1092
 None
 1.07A 4m2xC-1g5uA:
undetectable		 4m2xC-1g5uA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 12 ILE A1105
ALA A1024
ILE A1026
LEU A1065
ILE A1092
 None
 1.03A 4m2xE-1g5uA:
undetectable		 4m2xE-1g5uA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 12 GLY A1069
VAL A1119
LEU A1020
GLY A1091
ILE A1092
 None
 1.09A 5vooA-1g5uA:
undetectable		 5vooA-1g5uA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 12 GLY A1069
VAL A1119
LEU A1020
GLY A1091
ILE A1092
 None
 1.10A 5vooB-1g5uA:
undetectable		 5vooB-1g5uA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 12 GLY A1069
VAL A1119
LEU A1020
GLY A1091
ILE A1092
 None
 1.10A 5vooC-1g5uA:
undetectable		 5vooC-1g5uA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 12 GLY A1069
VAL A1119
LEU A1020
GLY A1091
ILE A1092
 None
 1.12A 5vooD-1g5uA:
undetectable		 5vooD-1g5uA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1g5u PROFILIN
(Hevea
brasiliensis) 		5 / 12 GLY A1069
VAL A1119
LEU A1020
GLY A1091
ILE A1092
 None
 1.17A 5vooF-1g5uA:
undetectable		 5vooF-1g5uA:
17.53