SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g61'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A2113
GLY A2117
ASP A2115
GLY A2151
ASN A2066
 None
 1.20A 3eeyJ-1g61A:
undetectable		 3eeyJ-1g61A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A2035
LYS A2034
ASP A2036
 None
 0.86A 4a7tA-1g61A:
0.0		 4a7tA-1g61A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		4 / 5 VAL A2040
LEU A2028
LEU A2032
ILE A2015
 None
 0.96A 4a9jA-1g61A:
undetectable		 4a9jA-1g61A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A2020
LEU A2107
LEU A2070
ILE A2053
ILE A2084
 None
 0.96A 4o2bB-1g61A:
undetectable		 4o2bB-1g61A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A2020
LEU A2107
LEU A2070
ILE A2053
ILE A2084
 None
 0.98A 4o2bD-1g61A:
undetectable		 4o2bD-1g61A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		4 / 4 GLY A2069
VAL A2064
PHE A2127
ILE A2100
 None
 1.03A 4xv2B-1g61A:
undetectable		 4xv2B-1g61A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A2020
LEU A2107
LEU A2070
ILE A2053
ILE A2084
 None
 0.93A 5itzB-1g61A:
undetectable		 5itzB-1g61A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A2225
TYR A2183
LYS A2159
LEU A2227
 None
 1.34A 5ki6A-1g61A:
undetectable		 5ki6A-1g61A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A2044
ILE A2201
ALA A2019
PHE A2009
 None
 0.95A 5m0oC-1g61A:
undetectable		 5m0oC-1g61A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A2020
LEU A2107
LEU A2070
ILE A2053
ILE A2084
 None
 0.94A 5mioB-1g61A:
undetectable		 5mioB-1g61A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A2020
LEU A2107
LEU A2070
ILE A2053
ILE A2084
 None
 0.98A 5nm5B-1g61A:
undetectable		 5nm5B-1g61A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A2071
VAL A2097
LEU A2020
ILE A2084
 None
 1.02A 5v0vA-1g61A:
undetectable		 5v0vA-1g61A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A2020
LEU A2107
LEU A2070
ILE A2053
ILE A2084
 None
 0.93A 5xiwB-1g61A:
undetectable		 5xiwB-1g61A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1g61 TRANSLATION
INITIATION FACTOR 6
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A2197
VAL A2064
ILE A2005
GLY A2210
PHE A2009
 None
 1.17A 6c2mB-1g61A:
0.0		 6c2mB-1g61A:
15.79