SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g65'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1g65 PROTEASOME COMPONENT
PUP3
(Saccharomyces
cerevisiae) 		4 / 7 LEU I 134
SER I 131
ASP I 132
PHE I 124
 None
MG  I 201 (-2.2A)
None
None
 1.24A 1ismB-1g65I:
undetectable		 1ismB-1g65I:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1g65 PROTEASOME COMPONENT
PUP3
(Saccharomyces
cerevisiae) 		4 / 7 ILE I 125
PHE I 109
ILE I 119
ASP I 120
 None
 0.66A 1yc2E-1g65I:
undetectable		 1yc2E-1g65I:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1g65 PROTEASOME COMPONENT
PUP3
(Saccharomyces
cerevisiae) 		6 / 12 PHE I  31
ASP I 166
ALA I 130
SER I 127
GLY I   1
GLY I  -1
 None
 1.26A 2w26A-1g65I:
undetectable		 2w26A-1g65I:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 1g65 PROTEASOME COMPONENT
PUP3
(Saccharomyces
cerevisiae) 		5 / 11 ALA I 158
LEU I 160
MET I 191
ALA I 173
VAL I 175
 None
 1.29A 3e22B-1g65I:
undetectable		 3e22B-1g65I:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 1g65 PROTEASOME COMPONENT
PUP3
(Saccharomyces
cerevisiae) 		5 / 11 ALA I 158
LEU I 160
MET I 191
ALA I 173
VAL I 175
 None
 1.26A 3e22D-1g65I:
undetectable		 3e22D-1g65I:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1g65 PROTEASOME COMPONENT
PUP3
(Saccharomyces
cerevisiae) 		5 / 12 THR I  63
PHE I 113
SER I  84
ILE I  45
LEU I  43
 None
 1.22A 3iv6D-1g65I:
undetectable		 3iv6D-1g65I:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 1g65 PROTEASOME COMPONENT
PUP3
(Saccharomyces
cerevisiae) 		3 / 3 GLU I 121
PHE I 109
GLN I  81
 None
 0.97A 3r55A-1g65I:
undetectable		 3r55A-1g65I:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1g65 PROTEASOME COMPONENT
PUP3
(Saccharomyces
cerevisiae) 		4 / 8 LEU I 151
THR I   7
ILE I 110
VAL I 100
 None
 0.92A 4eq4B-1g65I:
undetectable		 4eq4B-1g65I:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1g65 PROTEASOME COMPONENT
PUP3
(Saccharomyces
cerevisiae) 		4 / 7 ILE I 125
PHE I 109
ILE I 119
ASP I 120
 None
 0.59A 4rmjA-1g65I:
undetectable		 4rmjA-1g65I:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1g65 PROTEASOME COMPONENT
PUP3
(Saccharomyces
cerevisiae) 		6 / 12 ALA I 158
LEU I 160
MET I 191
ALA I 173
VAL I 175
ALA I  15
 None
 1.36A 4x1iB-1g65I:
undetectable		 4x1iB-1g65I:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1g65 PROTEASOME COMPONENT
PUP3
(Saccharomyces
cerevisiae) 		5 / 12 ALA I 158
LEU I 160
ALA I 173
VAL I 175
ALA I  15
 None
 0.88A 4x20B-1g65I:
undetectable		 4x20B-1g65I:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1g65 PROTEASOME COMPONENT
PUP3
(Saccharomyces
cerevisiae) 		4 / 6 LEU I 159
ALA I 130
SER I 127
THR I 129
 None
 1.08A 5bojA-1g65I:
undetectable		 5bojA-1g65I:
26.26