SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_F_FUAF704_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	1g6g	PROTEIN KINASE RAD53 (Saccharomyces cerevisiae)	5 / 11	THR A 39 PHE A 146 SER A 142 LEU A 111 THR A 131	None	1.39A	1q23F-1g6gA: 0.0	1q23F-1g6gA: 18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AZY_A_CHDA237_0 (PHOSPHOLIPASE A2, MAJOR ISOENZYME)	1g6g	PROTEIN KINASE RAD53 (Saccharomyces cerevisiae)	5 / 11	ILE A 147 ASP A 47 GLY A 29 LEU A 93 PHE A 151	None	1.18A	2azyA-1g6gA: undetectable	2azyA-1g6gA: 15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OJ4_A_DIFA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	1g6g	PROTEIN KINASE RAD53 (Saccharomyces cerevisiae)	4 / 8	LEU A 78 LEU A 141 VAL A 132 ILE A 130	None	0.94A	4oj4A-1g6gA: 0.0	4oj4A-1g6gA: 19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XR4_B_AG2B511_1 (HOMOSPERMIDINE SYNTHASE)	1g6g	PROTEIN KINASE RAD53 (Saccharomyces cerevisiae)	3 / 3	VAL A 132 PHE A 68 ARG A 46	None	0.82A	4xr4B-1g6gA: undetectable	4xr4B-1g6gA: 12.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Q23_F_FUAF704_1","CHLORAMPHENICOL ACETYLTRANSFERASE","1g6g","PROTEIN KINASE RAD53","Saccharomyces cerevisiae",5,"THR A  39;PHE A 146;SER A 142;LEU A 111;THR A 131","None","1.39A","1q23F-1g6gA:0.0","1q23F-1g6gA:18.10"],["2AZY_A_CHDA237_0","PHOSPHOLIPASE A2, MAJOR ISOENZYME","1g6g","PROTEIN KINASE RAD53","Saccharomyces cerevisiae",5,"ILE A 147;ASP A  47;GLY A  29;LEU A  93;PHE A 151","None","1.18A","2azyA-1g6gA:undetectable","2azyA-1g6gA:15.50"],["4OJ4_A_DIFA501_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","1g6g","PROTEIN KINASE RAD53","Saccharomyces cerevisiae",4,"LEU A  78;LEU A 141;VAL A 132;ILE A 130","None","0.94A","4oj4A-1g6gA:0.0","4oj4A-1g6gA:19.42"],["4XR4_B_AG2B511_1","HOMOSPERMIDINE SYNTHASE","1g6g","PROTEIN KINASE RAD53","Saccharomyces cerevisiae",3,"VAL A 132;PHE A  68;ARG A  46","None","0.82A","4xr4B-1g6gA:undetectable","4xr4B-1g6gA:12.50"]]