SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g71'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		5 / 9 THR A 284
GLY A 281
TYR A 278
LEU A 124
THR A 128
 None
 1.27A 2npnA-1g71A:
undetectable		 2npnA-1g71A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 174
SER A 146
ALA A 305
LEU A 291
ILE A 152
 None
 1.17A 2xkwB-1g71A:
1.1		 2xkwB-1g71A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		4 / 8 PRO A 320
ASN A 319
HIS A 323
VAL A 308
 None
 0.78A 3em0B-1g71A:
undetectable		 3em0B-1g71A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		4 / 7 PHE A 255
PHE A 268
LYS A 266
GLY A 226
 None
 1.00A 3em0B-1g71A:
0.0		 3em0B-1g71A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		5 / 8 PHE A 196
PHE A 206
PHE A 268
ALA A 269
THR A 272
 None
 1.48A 3t3sF-1g71A:
0.0		 3t3sF-1g71A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		3 / 3 ASP A 237
ARG A 229
LYS A 233
 None
 1.25A 3wipG-1g71A:
0.0		 3wipG-1g71A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		3 / 3 TYR A  72
HIS A 298
ARG A 292
 None
SO4  A 352 (-4.0A)
SO4  A 352 (-3.9A)
 1.11A 4htfA-1g71A:
undetectable		 4htfA-1g71A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		4 / 9 SER A 146
ALA A 305
LEU A 291
ILE A 152
 None
 0.96A 4xtaA-1g71A:
undetectable		 4xtaA-1g71A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		3 / 3 LYS A 239
ILE A 235
ILE A 227
 None
 0.72A 4y0qA-1g71A:
0.0		 4y0qA-1g71A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		4 / 6 PHE A 173
SER A 177
ALA A 176
LEU A 171
 None
 0.93A 5dzkB-1g71A:
undetectable
5dzkP-1g71A:
undetectable		 5dzkB-1g71A:
19.54
5dzkP-1g71A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		4 / 7 PHE A 173
SER A 177
ALA A 176
LEU A 171
 None
 1.04A 5dzkD-1g71A:
undetectable
5dzkR-1g71A:
undetectable		 5dzkD-1g71A:
19.54
5dzkR-1g71A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		4 / 5 ASP A 120
ARG A 105
LEU A   2
MET A   3
 None
 1.42A 5tuiB-1g71A:
undetectable		 5tuiB-1g71A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		5 / 10 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
 None
 1.00A 6ebpD-1g71A:
undetectable		 6ebpD-1g71A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		5 / 11 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
 None
 1.02A 6ebzA-1g71A:
undetectable		 6ebzA-1g71A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		5 / 11 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
 None
 1.02A 6ebzB-1g71A:
undetectable		 6ebzB-1g71A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		5 / 11 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
 None
 1.00A 6ebzD-1g71A:
undetectable		 6ebzD-1g71A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		4 / 8 ILE A 131
THR A 284
VAL A 285
GLU A 168
 None
 1.14A 6fbvC-1g71A:
0.0		 6fbvC-1g71A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		5 / 11 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
 None
 1.05A 6gp2A-1g71A:
undetectable		 6gp2A-1g71A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		5 / 11 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
 None
 1.03A 6gp2B-1g71A:
undetectable		 6gp2B-1g71A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 1g71 DNA PRIMASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 152
ILE A 154
THR A 310
ILE A 141
PHE A  27
 None
 1.07A 6hlpA-1g71A:
undetectable		 6hlpA-1g71A:
20.60