SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g7c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 132
HIS A 136
PRO A  93
 None
 0.94A 1d8cA-1g7cA:
undetectable		 1d8cA-1g7cA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 THR A 267
THR A 240
PRO A 239
 None
 0.83A 1dscC-1g7cA:
undetectable		 1dscC-1g7cA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 385
GLU A 375
THR A 341
ALA A 397
 None
 0.99A 1etb2-1g7cA:
0.0		 1etb2-1g7cA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 385
GLU A 375
THR A 341
ALA A 397
 None
 0.93A 1sn5C-1g7cA:
undetectable		 1sn5C-1g7cA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		5 / 8 THR A  82
THR A  24
LEU A 227
VAL A  10
VAL A  12
 None
 1.47A 1t86A-1g7cA:
0.0		 1t86A-1g7cA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		5 / 9 THR A  82
THR A  24
LEU A 227
VAL A  10
VAL A  12
 None
 1.44A 1t86B-1g7cA:
0.0		 1t86B-1g7cA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 187
THR A 185
PRO A 183
 None
 0.84A 2d55C-1g7cA:
undetectable		 2d55C-1g7cA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 389
LEU A 359
ALA A 423
THR A 430
ILE A 351
 None
 1.21A 2jjpA-1g7cA:
undetectable		 2jjpA-1g7cA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 330
PRO A 332
GLY A 334
LEU A 419
TYR A 416
 None
 1.30A 2uvnB-1g7cA:
0.0		 2uvnB-1g7cA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 THR A 240
PRO A 239
THR A 267
 None
 0.78A 316dC-1g7cA:
undetectable		 316dC-1g7cA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 402
ILE A 436
PHE A 338
PHE A 422
VAL A 344
 None
 1.27A 3a9eB-1g7cA:
0.0		 3a9eB-1g7cA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 425
GLU A 135
ASP A 130
 None
 0.81A 3g2oA-1g7cA:
undetectable		 3g2oA-1g7cA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		4 / 4 ARG A  67
ASP A  17
GLY A  14
THR A  24
 None
 1.28A 3k4vB-1g7cA:
0.0		 3k4vB-1g7cA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 377
ALA A 397
LYS A 376
 None
 0.97A 3runA-1g7cA:
0.0		 3runA-1g7cA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 115
THR A  23
THR A  24
SER A  21
 None
None
None
5GP  A 507 (-3.5A)
 1.13A 3snfA-1g7cA:
undetectable		 3snfA-1g7cA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZO_B_SPMB432_1
(PUTATIVE CYTOCHROME
P450)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		4 / 4 LYS A  79
ALA A  76
THR A  88
HIS A   7
 None
 1.05A 3tzoB-1g7cA:
0.0		 3tzoB-1g7cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 374
ASN A 339
VAL A 342
ILE A 366
 None
 0.95A 4eyrA-1g7cA:
0.0		 4eyrA-1g7cA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 338
MET A 408
ILE A 436
VAL A 424
 None
 1.32A 4mk4B-1g7cA:
undetectable		 4mk4B-1g7cA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 THR A 185
ASN A 174
PHE A 175
 None
 0.80A 4pd9A-1g7cA:
0.0		 4pd9A-1g7cA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 402
PHE A 338
ALA A 423
THR A 104
ALA A 364
 None
 1.08A 5vcgA-1g7cA:
0.0		 5vcgA-1g7cA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  63
ASP A  35
ASP A  74
ARG A  67
 None
 1.28A 6g31D-1g7cA:
undetectable		 6g31D-1g7cA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  63
ASP A  35
ASP A  74
ARG A  67
 None
 1.32A 6g31E-1g7cA:
undetectable		 6g31E-1g7cA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 TRP A  78
ILE A  90
ASP A  91
 None
 0.90A 6i0y7-1g7cA:
undetectable		 6i0y7-1g7cA:
4.88