SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		5 / 12 GLY A  47
LEU A  30
VAL A 223
LEU A  88
ALA A  89
 None
 1.07A 1gseB-1g8wA:
undetectable		 1gseB-1g8wA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		3 / 3 ALA A  91
GLY A 107
SER A  97
 None
 0.59A 2ivuA-1g8wA:
0.0		 2ivuA-1g8wA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		6 / 12 ILE A 213
GLY A  87
GLY A 103
ASN A  75
ASN A 217
PRO A  84
 None
 1.14A 2y7hB-1g8wA:
undetectable		 2y7hB-1g8wA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		5 / 12 ILE A 213
GLY A  87
GLY A 103
ASN A 217
PRO A  84
 None
 0.99A 2y7hC-1g8wA:
undetectable		 2y7hC-1g8wA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		4 / 7 LEU A 108
ASP A 141
SER A 208
THR A 210
 None
 1.38A 3dzgB-1g8wA:
undetectable		 3dzgB-1g8wA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		4 / 7 ALA A  89
ALA A 176
GLY A 139
ILE A 138
 None
 0.68A 4eatA-1g8wA:
undetectable		 4eatA-1g8wA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		4 / 8 ASN A  15
VAL A  24
LEU A  30
GLY A 206
 None
 0.90A 4r3aA-1g8wA:
undetectable		 4r3aA-1g8wA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		4 / 6 LYS A 100
LEU A 108
VAL A  93
PHE A 116
 None
 1.07A 4uswA-1g8wA:
undetectable		 4uswA-1g8wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		5 / 9 PHE A  11
LEU A  16
LEU A  88
THR A  73
PHE A  90
 None
 1.46A 4wnvB-1g8wA:
0.0		 4wnvB-1g8wA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		5 / 12 LEU A 199
ILE A  57
LYS A   1
VAL A 193
LEU A 174
 None
 1.08A 4y0qA-1g8wA:
0.0		 4y0qA-1g8wA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		5 / 12 LEU A  92
LEU A 199
ILE A  57
LYS A   1
VAL A 193
 None
 0.86A 4y0sA-1g8wA:
0.0		 4y0sA-1g8wA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		5 / 8 VAL A 205
VAL A 175
ILE A 138
ILE A 188
PHE A  72
 None
 1.38A 5hi2A-1g8wA:
undetectable		 5hi2A-1g8wA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		5 / 12 ALA A 120
LEU A 195
ILE A  57
VAL A 205
PHE A 228
 None
 1.24A 5vlmE-1g8wA:
undetectable		 5vlmE-1g8wA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		5 / 12 ALA A 120
LEU A 195
ILE A  57
VAL A 205
PHE A 228
 None
 1.28A 5vlmG-1g8wA:
undetectable		 5vlmG-1g8wA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ
(Phaseolus
vulgaris) 		5 / 10 ASP A  86
GLY A 103
ASP A 222
THR A 220
SER A 208
 None
 1.49A 6mn1B-1g8wA:
0.0		 6mn1B-1g8wA:
18.22