SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1g8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 ILE A 657
ALA A 183
GLY A 184
GLU A 187
ASN A 227
 None
ADP  A1100 (-4.1A)
ADP  A1100 (-3.2A)
ADP  A1100 (-4.6A)
None
 1.02A 1n6cA-1g8xA:
0.0		 1n6cA-1g8xA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		3 / 3 ALA A 983
VAL A 979
TRP A 976
 None
 0.84A 1nt6A-1g8xA:
undetectable		 1nt6A-1g8xA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		3 / 3 ALA A 983
VAL A 979
TRP A 976
 None
 0.84A 1nt6B-1g8xA:
undetectable		 1nt6B-1g8xA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 7 ARG A 131
TYR A 135
ILE A 115
PRO A 128
 ADP  A1100 ( 4.0A)
None
None
ADP  A1100 ( 4.6A)
 1.12A 1oniA-1g8xA:
undetectable
1oniB-1g8xA:
undetectable		 1oniA-1g8xA:
8.62
1oniB-1g8xA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 6 ARG A 131
TYR A 135
ILE A 115
PRO A 128
 ADP  A1100 ( 4.0A)
None
None
ADP  A1100 ( 4.6A)
 1.12A 1oniH-1g8xA:
undetectable
1oniI-1g8xA:
undetectable		 1oniH-1g8xA:
8.62
1oniI-1g8xA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 7 TYR A 135
ILE A 115
PRO A 128
ARG A 131
 None
None
ADP  A1100 ( 4.6A)
ADP  A1100 ( 4.0A)
 1.11A 1oniG-1g8xA:
undetectable
1oniI-1g8xA:
undetectable		 1oniG-1g8xA:
8.62
1oniI-1g8xA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 8 TYR A 634
TYR A 261
LEU A 645
MET A 642
 None
 1.48A 1uw6A-1g8xA:
0.0
1uw6B-1g8xA:
0.0		 1uw6A-1g8xA:
11.67
1uw6B-1g8xA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 8 TYR A 634
TYR A 261
LEU A 645
MET A 642
 None
 1.48A 1uw6D-1g8xA:
0.0
1uw6E-1g8xA:
0.0		 1uw6D-1g8xA:
11.67
1uw6E-1g8xA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 8 TYR A 634
TYR A 261
LEU A 645
MET A 642
 None
 1.48A 1uw6G-1g8xA:
0.0
1uw6H-1g8xA:
0.0		 1uw6G-1g8xA:
11.67
1uw6H-1g8xA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 10 LEU A 997
GLU A 993
LEU A 994
ILE A 918
LEU A 925
 None
 1.12A 1wopA-1g8xA:
0.0		 1wopA-1g8xA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 5 ILE A 344
ILE A 221
MET A 331
LEU A 352
 None
 0.94A 1zgyA-1g8xA:
0.0		 1zgyA-1g8xA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 7 GLY A 287
PHE A 324
ASP A 322
THR A 327
 None
 1.14A 2aouB-1g8xA:
undetectable		 2aouB-1g8xA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 LEU A 307
LEU A 285
ILE A 280
ILE A 348
ALA A 349
 None
 1.08A 2bxcA-1g8xA:
undetectable		 2bxcA-1g8xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 ILE A 280
PHE A 430
TYR A 426
ARG A 267
GLY A 226
 None
 1.09A 2bxmA-1g8xA:
2.9		 2bxmA-1g8xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 LEU A 284
LEU A 433
PHE A 430
TYR A 426
GLY A 226
 None
 1.02A 2bxmA-1g8xA:
2.9		 2bxmA-1g8xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 10 ILE A 280
PHE A 430
TYR A 426
ARG A 267
GLY A 226
 None
 1.18A 2bxqA-1g8xA:
0.7		 2bxqA-1g8xA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 LEU A 307
LEU A 285
ILE A 280
ILE A 348
ALA A 349
 None
 0.97A 2bxqA-1g8xA:
1.7		 2bxqA-1g8xA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 6 LEU A  94
VAL A 108
ILE A  83
ARG A   7
 None
 0.98A 2hyyA-1g8xA:
undetectable		 2hyyA-1g8xA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		3 / 3 TRP A 976
ALA A 983
VAL A 979
 None
 0.76A 2izqA-1g8xA:
undetectable
2izqB-1g8xA:
undetectable		 2izqA-1g8xA:
1.83
2izqB-1g8xA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		3 / 3 ARG A 842
ASN A 831
THR A 767
 None
 0.84A 2q63A-1g8xA:
undetectable		 2q63A-1g8xA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		3 / 3 ASN A 464
LEU A 469
HIS A 572
 None
 0.86A 2q6fB-1g8xA:
0.0		 2q6fB-1g8xA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 7 ILE A 132
ARG A 131
TYR A 116
GLU A 187
 None
ADP  A1100 ( 4.0A)
None
ADP  A1100 (-4.6A)
 1.05A 2qebA-1g8xA:
0.0		 2qebA-1g8xA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 7 ILE A 132
ARG A 131
TYR A 116
GLU A 187
 None
ADP  A1100 ( 4.0A)
None
ADP  A1100 (-4.6A)
 1.07A 2qebB-1g8xA:
undetectable		 2qebB-1g8xA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 7 GLY A 427
GLY A 350
PHE A 600
PHE A 612
 None
 0.92A 2qwxA-1g8xA:
undetectable
2qwxB-1g8xA:
undetectable		 2qwxA-1g8xA:
14.36
2qwxB-1g8xA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 10 ALA A 392
LEU A 425
LEU A 354
LEU A 389
LEU A 421
 None
 1.06A 2riwA-1g8xA:
0.0
2riwB-1g8xA:
0.0		 2riwA-1g8xA:
16.87
2riwB-1g8xA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 10 ALA A 392
LEU A 425
LEU A 354
LEU A 389
LEU A 421
 None
 1.13A 2xn6A-1g8xA:
0.0
2xn6B-1g8xA:
0.0		 2xn6A-1g8xA:
16.83
2xn6B-1g8xA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 10 ALA A 392
LEU A 425
LEU A 354
LEU A 389
LEU A 421
 None
 1.13A 2xn7A-1g8xA:
0.0
2xn7B-1g8xA:
0.0		 2xn7A-1g8xA:
16.63
2xn7B-1g8xA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 5 ILE A 326
PRO A 220
VAL A 381
PHE A 225
 None
 1.27A 2ygnA-1g8xA:
0.0		 2ygnA-1g8xA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ASN A 660
ARG A 232
GLY A 179
ILE A 177
ASN A 188
 None
 1.40A 3a25A-1g8xA:
undetectable		 3a25A-1g8xA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 PHE A 701
LEU A 730
ILE A 732
PHE A 746
VAL A 712
 None
 1.21A 3a9eB-1g8xA:
undetectable		 3a9eB-1g8xA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 8 GLY A 575
GLU A 476
ASN A 472
ILE A 460
 None
 0.94A 3aodA-1g8xA:
0.0		 3aodA-1g8xA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 PHE A 122
ILE A 685
SER A  92
LEU A 676
THR A 178
 None
 1.17A 3nrrA-1g8xA:
undetectable		 3nrrA-1g8xA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 PHE A 122
ILE A 685
SER A  92
LEU A 676
THR A 178
 None
 1.09A 3nrrB-1g8xA:
undetectable		 3nrrB-1g8xA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 6 GLU A 292
PHE A 345
THR A 327
ALA A 288
 None
 1.18A 3ns1C-1g8xA:
0.0		 3ns1C-1g8xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 9 GLY A 287
ALA A 288
MET A 342
ILE A 280
LEU A 298
 None
 0.98A 3ogpA-1g8xA:
undetectable		 3ogpA-1g8xA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 9 ILE A 450
ILE A 245
ALA A 197
LEU A 196
LEU A 175
 None
 0.73A 3ozvB-1g8xA:
0.0		 3ozvB-1g8xA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 8 LEU A 307
GLN A 271
TYR A 282
PHE A 281
 None
 1.30A 3po7A-1g8xA:
undetectable		 3po7A-1g8xA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 GLY A 427
LEU A 222
PHE A 281
ILE A 348
ILE A 347
 None
 0.97A 3pwwA-1g8xA:
undetectable		 3pwwA-1g8xA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 7 LEU A 592
ILE A 347
VAL A 608
LEU A 611
 None
 0.70A 3r9vA-1g8xA:
0.0
3r9vB-1g8xA:
0.0		 3r9vA-1g8xA:
15.67
3r9vB-1g8xA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		3 / 3 GLY A 182
GLY A 184
THR A 186
 ADP  A1100 (-3.6A)
ADP  A1100 (-3.2A)
MG  A1101 ( 3.4A)
 0.42A 3si7B-1g8xA:
0.0		 3si7B-1g8xA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 5 PHE A 103
TYR A 110
LEU A  97
ARG A 109
 None
 1.00A 3sudD-1g8xA:
0.0		 3sudD-1g8xA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		3 / 3 TYR A 110
LEU A  97
ARG A 109
 None
 0.76A 3sufB-1g8xA:
0.0		 3sufB-1g8xA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		3 / 3 PHE A 461
SER A 456
SER A 181
 None
None
ADP  A1100 ( 4.4A)
 0.90A 3ufgB-1g8xA:
0.0		 3ufgB-1g8xA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		3 / 3 PHE A 804
SER A 788
SER A 791
 None
 0.70A 3ufgB-1g8xA:
0.0		 3ufgB-1g8xA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 471
GLY A 457
LYS A 185
ASP A 454
LEU A 478
 None
None
ADP  A1100 (-3.2A)
MG  A1101 ( 4.3A)
None
 1.14A 4a81A-1g8xA:
undetectable		 4a81A-1g8xA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 VAL A 434
TYR A 261
VAL A 452
ILE A 177
LEU A 222
 None
 1.30A 4a84A-1g8xA:
undetectable		 4a84A-1g8xA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 ILE A 657
ALA A 183
GLY A 184
GLU A 187
ASN A 227
 None
ADP  A1100 (-4.1A)
ADP  A1100 (-3.2A)
ADP  A1100 (-4.6A)
None
 1.05A 4e47A-1g8xA:
undetectable		 4e47A-1g8xA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 ILE A 657
ALA A 183
GLY A 184
GLU A 187
ASN A 227
 None
ADP  A1100 (-4.1A)
ADP  A1100 (-3.2A)
ADP  A1100 (-4.6A)
None
 1.08A 4e47B-1g8xA:
undetectable		 4e47B-1g8xA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 ILE A 657
ALA A 183
GLY A 184
GLU A 187
ASN A 227
 None
ADP  A1100 (-4.1A)
ADP  A1100 (-3.2A)
ADP  A1100 (-4.6A)
None
 1.04A 4e47C-1g8xA:
undetectable		 4e47C-1g8xA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 ILE A 657
ALA A 183
GLY A 184
GLU A 187
ASN A 227
 None
ADP  A1100 (-4.1A)
ADP  A1100 (-3.2A)
ADP  A1100 (-4.6A)
None
 1.10A 4jdsA-1g8xA:
undetectable		 4jdsA-1g8xA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 ILE A 657
ALA A 183
GLY A 184
GLU A 187
ASN A 227
 None
ADP  A1100 (-4.1A)
ADP  A1100 (-3.2A)
ADP  A1100 (-4.6A)
None
 1.08A 4jdsB-1g8xA:
undetectable		 4jdsB-1g8xA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 ILE A 657
ALA A 183
GLY A 184
GLU A 187
ASN A 227
 None
ADP  A1100 (-4.1A)
ADP  A1100 (-3.2A)
ADP  A1100 (-4.6A)
None
 1.07A 4jdsC-1g8xA:
undetectable		 4jdsC-1g8xA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 657
ALA A 183
GLY A 184
GLU A 187
ASN A 227
 None
ADP  A1100 (-4.1A)
ADP  A1100 (-3.2A)
ADP  A1100 (-4.6A)
None
 1.04A 4jlgA-1g8xA:
0.0		 4jlgA-1g8xA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		3 / 3 ARG A 232
ASP A 674
ASP A 669
 None
 0.89A 4kicB-1g8xA:
0.1		 4kicB-1g8xA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ASN A 219
ASP A 454
ILE A 455
SER A 456
ASN A 235
 None
MG  A1101 ( 4.3A)
None
None
None
 1.36A 4pooB-1g8xA:
undetectable		 4pooB-1g8xA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 6 ALA A 256
GLY A 451
ILE A 215
VAL A 192
 None
 0.75A 4r21A-1g8xA:
undetectable		 4r21A-1g8xA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 4 ASN A 679
VAL A 124
THR A 178
ILE A 177
 None
 1.21A 4retA-1g8xA:
0.0		 4retA-1g8xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 4 ASN A 679
VAL A 124
THR A 178
ILE A 177
 None
 1.21A 4retC-1g8xA:
0.0		 4retC-1g8xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		3 / 3 GLU A 238
ARG A 267
GLN A 468
 None
 0.96A 4rtbA-1g8xA:
undetectable		 4rtbA-1g8xA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 LEU A 425
ILE A 351
GLY A 350
VAL A 384
LEU A 389
 None
 1.10A 4y8wA-1g8xA:
0.1		 4y8wA-1g8xA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 LEU A 425
ILE A 351
GLY A 350
VAL A 384
LEU A 389
 None
 1.08A 4y8wB-1g8xA:
0.0		 4y8wB-1g8xA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 ILE A 657
ALA A 183
GLY A 184
GLU A 187
ASN A 227
 None
ADP  A1100 (-4.1A)
ADP  A1100 (-3.2A)
ADP  A1100 (-4.6A)
None
 0.99A 5ayfA-1g8xA:
undetectable		 5ayfA-1g8xA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		4 / 4 TYR A 705
GLY A 749
SER A  95
LEU A 751
 None
 1.32A 5bphC-1g8xA:
undetectable		 5bphC-1g8xA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		3 / 3 ASN A 892
LEU A 950
PHE A 971
 None
 0.81A 5dsgA-1g8xA:
1.9		 5dsgA-1g8xA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 TYR A 135
LEU A 123
ILE A 158
LEU A 175
GLY A 451
 None
 1.19A 5ienA-1g8xA:
0.0		 5ienA-1g8xA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.06A 5n0oA-1g8xA:
undetectable		 5n0oA-1g8xA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.07A 5n0oB-1g8xA:
1.4		 5n0oB-1g8xA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.07A 5n0rA-1g8xA:
0.0		 5n0rA-1g8xA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.10A 5n0sA-1g8xA:
0.1		 5n0sA-1g8xA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.07A 5n0tA-1g8xA:
0.2		 5n0tA-1g8xA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.09A 5n0wA-1g8xA:
0.0		 5n0wA-1g8xA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.09A 5n0wB-1g8xA:
0.0		 5n0wB-1g8xA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.06A 5n0xA-1g8xA:
0.0		 5n0xA-1g8xA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.06A 5n0xB-1g8xA:
0.0		 5n0xB-1g8xA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 253
GLY A 255
PHE A 449
TYR A 163
ALA A 200
 None
 1.08A 5n4iA-1g8xA:
0.0		 5n4iA-1g8xA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 THR A 647
THR A 644
LEU A 478
SER A 174
GLN A 173
 None
 1.40A 6ak3A-1g8xA:
1.8		 6ak3A-1g8xA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 THR A 647
THR A 644
LEU A 478
SER A 174
GLN A 173
 None
 1.39A 6ak3B-1g8xA:
2.7		 6ak3B-1g8xA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 MET A 342
SER A 379
VAL A 384
LEU A 298
ALA A 349
 None
 1.11A 6djzC-1g8xA:
0.0		 6djzC-1g8xA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 12 ILE A 347
SER A 343
LEU A 421
PHE A 600
ASP A 605
 None
 1.32A 6dwnB-1g8xA:
0.0		 6dwnB-1g8xA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 LEU A 529
ASP A 530
GLY A 519
ILE A 517
PHE A 466
 None
 1.07A 6ebzD-1g8xA:
undetectable		 6ebzD-1g8xA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 LEU A 529
ASP A 530
GLY A 519
ILE A 517
PHE A 466
 None
 0.92A 6gp2A-1g8xA:
undetectable		 6gp2A-1g8xA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3
(Dictyostelium
discoideum) 		5 / 11 LEU A 529
ASP A 530
GLY A 519
ILE A 517
PHE A 466
 None
 0.92A 6gp2B-1g8xA:
undetectable		 6gp2B-1g8xA:
6.54