SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ga8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 9 LEU A 192
TRP A 164
VAL A 200
GLY A 126
ALA A 127
 None
 1.15A 1pxxB-1ga8A:
undetectable		 1pxxB-1ga8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 10 LEU A 192
TRP A 164
VAL A 200
GLY A 126
ALA A 127
 None
 1.16A 1pxxD-1ga8A:
0.0		 1pxxD-1ga8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 12 LEU A 157
ASP A   2
VAL A   4
ILE A  93
GLY A  90
 None
 0.92A 2f8gB-1ga8A:
undetectable		 2f8gB-1ga8A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		4 / 6 LEU A 271
PRO A 275
ALA A  47
ALA A  12
 None
 0.94A 2vcvK-1ga8A:
0.0		 2vcvK-1ga8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 10 LEU A 157
ASP A   2
VAL A   4
ILE A  93
GLY A  90
 None
 0.93A 3em3B-1ga8A:
undetectable		 3em3B-1ga8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 12 LEU A 157
ASP A   2
VAL A   4
ILE A  93
GLY A  90
 None
 0.81A 3em6B-1ga8A:
undetectable		 3em6B-1ga8A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 10 ASP A   2
VAL A   4
ILE A  93
GLY A  90
ILE A 169
 None
 0.90A 3nu6A-1ga8A:
0.0		 3nu6A-1ga8A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 10 ASP A   2
VAL A   4
ILE A  93
GLY A  90
ILE A 169
 None
 0.92A 3nujA-1ga8A:
undetectable		 3nujA-1ga8A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 10 LEU A 157
ASP A   2
VAL A   4
ILE A  93
GLY A  90
 None
 1.06A 3oxwB-1ga8A:
undetectable		 3oxwB-1ga8A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 11 LEU A 192
TRP A 164
VAL A 200
GLY A 126
ALA A 127
 None
 1.21A 3pghB-1ga8A:
0.0		 3pghB-1ga8A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 12 ASP A   2
VAL A   4
ILE A  93
GLY A  90
ILE A 169
 None
 0.78A 3so9B-1ga8A:
undetectable		 3so9B-1ga8A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 10 ASP A   2
VAL A   4
ILE A  93
GLY A  90
ILE A 169
 None
 0.91A 3t3cB-1ga8A:
undetectable		 3t3cB-1ga8A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 12 LEU A 192
TRP A 164
VAL A 200
GLY A 126
ALA A 127
 None
 1.11A 4coxC-1ga8A:
0.0		 4coxC-1ga8A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		6 / 12 LEU A 158
GLY A 198
GLY A 199
LEU A 120
ASN A 193
GLY A 194
 None
 1.48A 4dc3B-1ga8A:
2.0		 4dc3B-1ga8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		6 / 12 LEU A 157
ASP A   2
VAL A   4
ILE A  93
GLY A  90
ILE A 169
 None
 1.06A 4dqfA-1ga8A:
undetectable		 4dqfA-1ga8A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		3 / 3 TYR A 245
ARG A 109
SER A 243
 None
 1.02A 4khpI-1ga8A:
0.0
4khpJ-1ga8A:
0.0		 4khpI-1ga8A:
18.91
4khpJ-1ga8A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		3 / 3 ASP A  37
TRP A 252
SER A  41
 None
 0.99A 4lrhA-1ga8A:
0.0		 4lrhA-1ga8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 11 ASP A   2
VAL A   4
ILE A  93
GLY A  90
ILE A 169
 None
 0.78A 4njtA-1ga8A:
undetectable		 4njtA-1ga8A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 11 LEU A 157
ASP A   2
VAL A   4
ILE A  93
GLY A  90
 None
 0.90A 4njtA-1ga8A:
undetectable		 4njtA-1ga8A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 11 ASP A   2
VAL A   4
ILE A  93
GLY A  90
ILE A 169
 None
 0.86A 4njtC-1ga8A:
undetectable		 4njtC-1ga8A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 12 LEU A 192
TRP A 164
VAL A 200
GLY A 126
ALA A 127
 None
 1.12A 4rrxA-1ga8A:
0.0		 4rrxA-1ga8A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 12 LEU A 192
TRP A 164
VAL A 200
GLY A 126
ALA A 127
 None
 1.12A 4rrxB-1ga8A:
0.0		 4rrxB-1ga8A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 11 ASP A   2
VAL A   4
ILE A  93
GLY A  90
ILE A 169
 None
 0.95A 4rvjA-1ga8A:
undetectable		 4rvjA-1ga8A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 11 ASP A   2
VAL A   4
ILE A  93
GLY A  90
ILE A 169
 None
 0.94A 4rvjC-1ga8A:
undetectable		 4rvjC-1ga8A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 12 VAL A 108
LEU A  52
VAL A  35
LEU A  15
PHE A   5
 None
 0.97A 4y0qA-1ga8A:
0.0		 4y0qA-1ga8A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		5 / 12 VAL A 108
LEU A  52
VAL A  35
LEU A  15
PHE A   5
 None
 0.95A 4y0sA-1ga8A:
0.0		 4y0sA-1ga8A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		3 / 3 ASN A 153
LEU A 115
PHE A 209
 UPF  A 501 (-3.0A)
None
None
 0.58A 5dsgA-1ga8A:
0.0		 5dsgA-1ga8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		3 / 3 VAL A 133
ARG A  77
PRO A 248
 DEL  A 500 (-4.8A)
None
None
 0.87A 5koxA-1ga8A:
0.9		 5koxA-1ga8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		3 / 3 ARG A 135
LYS A 222
TYR A 230
 None
 1.33A 6gnaA-1ga8A:
undetectable		 6gnaA-1ga8A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1ga8 GALACTOSYL
TRANSFERASE LGTC
(Neisseria
meningitidis) 		3 / 3 ARG A 135
LYS A 222
TYR A 230
 None
 1.33A 6gnbA-1ga8A:
undetectable		 6gnbA-1ga8A:
25.36