SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gan'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gan GALECTIN-1
(Rhinella
arenarum) 		5 / 9 GLY A  22
GLY A   4
PHE A 128
LEU A 123
GLY A 125
 None
 1.09A 1jhoA-1ganA:
undetectable		 1jhoA-1ganA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gan GALECTIN-1
(Rhinella
arenarum) 		5 / 8 GLY A  22
GLY A   4
PHE A 128
LEU A 123
GLY A 125
 None
 1.13A 1jhqA-1ganA:
undetectable		 1jhqA-1ganA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gan GALECTIN-1
(Rhinella
arenarum) 		5 / 9 GLY A  22
GLY A   4
PHE A 128
LEU A 123
GLY A 125
 None
 1.12A 1jhrA-1ganA:
undetectable		 1jhrA-1ganA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gan GALECTIN-1
(Rhinella
arenarum) 		5 / 8 GLY A  22
GLY A   4
PHE A 128
LEU A 123
GLY A 125
 None
 1.10A 1jhvA-1ganA:
undetectable		 1jhvA-1ganA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gan GALECTIN-1
(Rhinella
arenarum) 		5 / 9 GLY A  22
GLY A   4
PHE A 128
LEU A 123
GLY A 125
 None
 1.11A 1jhyA-1ganA:
undetectable		 1jhyA-1ganA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gan GALECTIN-1
(Rhinella
arenarum) 		5 / 9 GLY A  22
GLY A   4
PHE A 128
LEU A 123
GLY A 125
 None
 1.11A 1l4nA-1ganA:
undetectable		 1l4nA-1ganA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gan GALECTIN-1
(Rhinella
arenarum) 		5 / 9 GLY A  22
GLY A   4
PHE A 128
LEU A 123
GLY A 125
 None
 1.08A 1l5kA-1ganA:
undetectable		 1l5kA-1ganA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gan GALECTIN-1
(Rhinella
arenarum) 		5 / 9 GLY A  22
GLY A   4
PHE A 128
LEU A 123
GLY A 125
 None
 1.10A 1l5lA-1ganA:
undetectable		 1l5lA-1ganA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gan GALECTIN-1
(Rhinella
arenarum) 		5 / 9 GLY A  22
GLY A   4
PHE A 128
LEU A 123
GLY A 125
 None
 1.11A 1l5mA-1ganA:
undetectable		 1l5mA-1ganA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1gan GALECTIN-1
(Rhinella
arenarum) 		4 / 7 PHE A  90
LEU A  35
LEU A  10
LEU A 121
 None
 0.94A 3bgdB-1ganA:
undetectable		 3bgdB-1ganA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 1gan GALECTIN-1
(Rhinella
arenarum) 		3 / 3 GLU A  19
VAL A  18
CYH A  89
 None
 1.06A 3fbxA-1ganA:
0.0		 3fbxA-1ganA:
15.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 1gan GALECTIN-1
(Rhinella
arenarum) 		6 / 6 HIS A  45
ASN A  47
ARG A  49
ASN A  62
TRP A  69
GLU A  72
 GAL  A 136 (-4.0A)
GAL  A 136 (-3.8A)
NDG  A 135 ( 2.8A)
GAL  A 136 (-3.7A)
GAL  A 136 (-3.7A)
NDG  A 135 ( 2.6A)
 0.20A 3galA-1ganA:
19.8		 3galA-1ganA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 1gan GALECTIN-1
(Rhinella
arenarum) 		6 / 6 HIS A  45
ASN A  47
ARG A  49
ASN A  62
TRP A  69
GLU A  72
 GAL  A 136 (-4.0A)
GAL  A 136 (-3.8A)
NDG  A 135 ( 2.8A)
GAL  A 136 (-3.7A)
GAL  A 136 (-3.7A)
NDG  A 135 ( 2.6A)
 0.20A 3galB-1ganA:
19.5		 3galB-1ganA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1gan GALECTIN-1
(Rhinella
arenarum) 		4 / 8 GLY A  22
CYH A  17
PHE A 107
PHE A 101
 None
 1.03A 3ko0D-1ganA:
undetectable
3ko0E-1ganA:
undetectable		 3ko0D-1ganA:
17.91
3ko0E-1ganA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1gan GALECTIN-1
(Rhinella
arenarum) 		4 / 8 PHE A 101
GLY A  22
CYH A  17
PHE A 107
 None
 1.07A 3ko0B-1ganA:
undetectable
3ko0J-1ganA:
undetectable		 3ko0B-1ganA:
17.91
3ko0J-1ganA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 1gan GALECTIN-1
(Rhinella
arenarum) 		5 / 10 PHE A  31
PHE A 107
VAL A  88
PHE A 101
PHE A  80
 None
 1.33A 3r6wA-1ganA:
undetectable
3r6wB-1ganA:
undetectable		 3r6wA-1ganA:
19.02
3r6wB-1ganA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 1gan GALECTIN-1
(Rhinella
arenarum) 		5 / 10 PHE A 107
VAL A  88
PHE A 101
PHE A  80
PHE A  31
 None
 1.37A 3r6wA-1ganA:
undetectable
3r6wB-1ganA:
undetectable		 3r6wA-1ganA:
19.02
3r6wB-1ganA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gan GALECTIN-1
(Rhinella
arenarum) 		5 / 9 GLY A  22
GLY A   4
PHE A 128
LEU A 123
GLY A 125
 None
 1.12A 4kqiA-1ganA:
undetectable		 4kqiA-1ganA:
16.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 1gan GALECTIN-1
(Rhinella
arenarum) 		7 / 7 HIS A  45
ASN A  47
ARG A  49
ASN A  62
TRP A  69
GLU A  72
ARG A  74
 GAL  A 136 (-4.0A)
GAL  A 136 (-3.8A)
NDG  A 135 ( 2.8A)
GAL  A 136 (-3.7A)
GAL  A 136 (-3.7A)
NDG  A 135 ( 2.6A)
NDG  A 135 (-3.4A)
 0.63A 6b8kA-1ganA:
19.7		 6b8kA-1ganA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 1gan GALECTIN-1
(Rhinella
arenarum) 		7 / 8 HIS A  45
ASN A  47
ARG A  49
HIS A  53
ASN A  62
TRP A  69
GLU A  72
 GAL  A 136 (-4.0A)
GAL  A 136 (-3.8A)
NDG  A 135 ( 2.8A)
GAL  A 136 (-3.7A)
GAL  A 136 (-3.7A)
GAL  A 136 (-3.7A)
NDG  A 135 ( 2.6A)
 0.40A 6b94A-1ganA:
24.6		 6b94A-1ganA:
60.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 1gan GALECTIN-1
(Rhinella
arenarum) 		7 / 8 HIS A  45
ASN A  47
ARG A  49
HIS A  53
TRP A  69
GLU A  72
ARG A  74
 GAL  A 136 (-4.0A)
GAL  A 136 (-3.8A)
NDG  A 135 ( 2.8A)
GAL  A 136 (-3.7A)
GAL  A 136 (-3.7A)
NDG  A 135 ( 2.6A)
NDG  A 135 (-3.4A)
 0.66A 6b94A-1ganA:
24.6		 6b94A-1ganA:
60.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 1gan GALECTIN-1
(Rhinella
arenarum) 		9 / 10 HIS A  45
ASN A  47
ARG A  49
HIS A  53
ASP A  55
ASN A  62
TRP A  69
GLU A  72
ARG A  74
 GAL  A 136 (-4.0A)
GAL  A 136 (-3.8A)
NDG  A 135 ( 2.8A)
GAL  A 136 (-3.7A)
None
GAL  A 136 (-3.7A)
GAL  A 136 (-3.7A)
NDG  A 135 ( 2.6A)
NDG  A 135 (-3.4A)
 0.67A 6b94A-1ganA:
24.6
6b94B-1ganA:
24.4		 6b94A-1ganA:
60.49
6b94B-1ganA:
60.49