SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gbg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		3 / 3 TRP A  34
PHE A  30
TRP A 184
 None
 1.46A 1r15C-1gbgA:
undetectable		 1r15C-1gbgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		3 / 3 TRP A  34
PHE A  30
TRP A 184
 None
 1.47A 1r15F-1gbgA:
undetectable		 1r15F-1gbgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		3 / 3 TRP A  34
PHE A  30
TRP A 184
 None
 1.46A 1r15G-1gbgA:
undetectable		 1r15G-1gbgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		3 / 3 TRP A  34
PHE A  30
TRP A 184
 None
 1.47A 1r15H-1gbgA:
undetectable		 1r15H-1gbgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		5 / 12 PHE A 110
PHE A 120
ALA A  82
ALA A 148
MET A  79
 None
 0.99A 2x2nA-1gbgA:
undetectable		 2x2nA-1gbgA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		4 / 7 GLU A  46
PHE A  10
TYR A 144
HIS A 145
 None
 1.07A 4a97A-1gbgA:
undetectable		 4a97A-1gbgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		4 / 6 GLU A  46
PHE A  10
TYR A 144
HIS A 145
 None
 1.11A 4a97E-1gbgA:
undetectable		 4a97E-1gbgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		4 / 5 GLU A  46
PHE A  10
TYR A 144
HIS A 145
 None
 1.06A 4a97J-1gbgA:
0.0		 4a97J-1gbgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		5 / 12 ASN A  12
GLU A   8
ASN A  64
HIS A 205
TYR A 206
 None
 1.21A 5cclA-1gbgA:
undetectable		 5cclA-1gbgA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		5 / 12 ASN A  12
GLU A   8
ASN A  64
HIS A 205
TYR A 206
 None
 1.19A 5ccmA-1gbgA:
undetectable		 5ccmA-1gbgA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		3 / 3 PHE A 149
ILE A 108
ASP A 161
 None
 0.74A 5cswA-1gbgA:
undetectable		 5cswA-1gbgA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		3 / 3 PHE A 149
ILE A 108
ASP A 161
 None
 0.69A 5cswB-1gbgA:
undetectable		 5cswB-1gbgA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		5 / 12 ASN A  12
GLU A   8
ASN A  64
HIS A 205
TYR A 206
 None
 1.21A 5xxgA-1gbgA:
undetectable		 5xxgA-1gbgA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		5 / 12 ASN A  12
GLU A   8
ASN A  64
HIS A 205
TYR A 206
 None
 1.20A 5xxjA-1gbgA:
undetectable		 5xxjA-1gbgA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE
(Bacillus
licheniformis) 		5 / 12 ASN A  12
GLU A   8
ASN A  64
HIS A 205
TYR A 206
 None
 1.21A 5yjoA-1gbgA:
undetectable		 5yjoA-1gbgA:
17.48