SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gc7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 1gc7 RADIXIN
(Mus
musculus) 		5 / 12 LEU A  29
LEU A  59
ARG A 279
LEU A  76
THR A  24
 LEU  A  29 ( 0.6A)
LEU  A  59 ( 0.6A)
ARG  A 279 ( 0.6A)
LEU  A  76 ( 0.6A)
THR  A  24 ( 0.8A)
 1.41A 1a28B-1gc7A:
undetectable		 1a28B-1gc7A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1gc7 RADIXIN
(Mus
musculus) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 VAL  A 220 ( 0.6A)
GLY  A 219 ( 0.0A)
LEU  A 218 ( 0.6A)
TYR  A 228 ( 1.3A)
GLY  A 224 ( 0.0A)
 1.01A 1fduA-1gc7A:
undetectable		 1fduA-1gc7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1gc7 RADIXIN
(Mus
musculus) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 VAL  A 220 ( 0.6A)
GLY  A 219 ( 0.0A)
LEU  A 218 ( 0.6A)
TYR  A 228 ( 1.3A)
GLY  A 224 ( 0.0A)
 1.00A 1fduC-1gc7A:
undetectable		 1fduC-1gc7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1gc7 RADIXIN
(Mus
musculus) 		5 / 11 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 VAL  A 220 ( 0.6A)
GLY  A 219 ( 0.0A)
LEU  A 218 ( 0.6A)
TYR  A 228 ( 1.3A)
GLY  A 224 ( 0.0A)
 1.15A 1iolA-1gc7A:
undetectable		 1iolA-1gc7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 7 PRO A  86
ALA A  82
PHE A  45
PHE A  44
 PRO  A  86 ( 1.1A)
ALA  A  82 ( 0.0A)
PHE  A  45 ( 1.3A)
PHE  A  44 ( 1.3A)
 1.19A 1lqtA-1gc7A:
undetectable		 1lqtA-1gc7A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 7 PRO A  86
ALA A  82
PHE A  45
PHE A  44
 PRO  A  86 ( 1.1A)
ALA  A  82 ( 0.0A)
PHE  A  45 ( 1.3A)
PHE  A  44 ( 1.3A)
 1.19A 1lquA-1gc7A:
undetectable		 1lquA-1gc7A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 6 ALA A 148
TYR A 146
ILE A 172
GLU A 169
 ALA  A 148 ( 0.0A)
TYR  A 146 ( 1.3A)
ILE  A 172 ( 0.7A)
GLU  A 169 ( 0.6A)
 1.29A 1oniB-1gc7A:
undetectable
1oniC-1gc7A:
undetectable		 1oniB-1gc7A:
17.03
1oniC-1gc7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 1gc7 RADIXIN
(Mus
musculus) 		5 / 12 LEU A  29
LEU A  59
ARG A 279
LEU A  76
THR A  24
 LEU  A  29 ( 0.6A)
LEU  A  59 ( 0.6A)
ARG  A 279 ( 0.6A)
LEU  A  76 ( 0.6A)
THR  A  24 ( 0.8A)
 1.28A 1zucB-1gc7A:
undetectable		 1zucB-1gc7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1gc7 RADIXIN
(Mus
musculus) 		5 / 9 THR A 121
ALA A 122
LEU A 124
ALA A 126
SER A 127
 THR  A 121 ( 0.8A)
ALA  A 122 ( 0.0A)
LEU  A 124 ( 0.6A)
ALA  A 126 ( 0.0A)
SER  A 127 ( 0.0A)
 1.50A 3kp6B-1gc7A:
0.0		 3kp6B-1gc7A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1gc7 RADIXIN
(Mus
musculus) 		3 / 3 ASP A 266
ARG A 246
LYS A 258
 ASP  A 266 ( 0.6A)
ARG  A 246 ( 0.6A)
LYS  A 258 ( 0.0A)
 0.98A 3wipG-1gc7A:
0.0		 3wipG-1gc7A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 7 LEU A 104
ASP A  13
ALA A  14
VAL A  33
 LEU  A 104 ( 0.6A)
ASP  A  13 ( 0.5A)
ALA  A  14 ( 0.0A)
VAL  A  33 ( 0.6A)
 0.94A 3wsjB-1gc7A:
0.0		 3wsjB-1gc7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.20A 5dzkb-1gc7A:
0.0
5dzkp-1gc7A:
undetectable		 5dzkb-1gc7A:
19.68
5dzkp-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 6 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.23A 5dzkB-1gc7A:
0.0
5dzkP-1gc7A:
undetectable		 5dzkB-1gc7A:
19.68
5dzkP-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.22A 5dzkc-1gc7A:
0.0
5dzkq-1gc7A:
undetectable		 5dzkc-1gc7A:
19.68
5dzkq-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 7 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.08A 5dzkD-1gc7A:
undetectable
5dzkR-1gc7A:
undetectable		 5dzkD-1gc7A:
19.68
5dzkR-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.06A 5dzkf-1gc7A:
0.0
5dzkt-1gc7A:
undetectable		 5dzkf-1gc7A:
19.68
5dzkt-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 5 PRO A 154
LEU A 234
TYR A 201
PHE A  85
 PRO  A 154 ( 1.1A)
LEU  A 234 ( 0.6A)
TYR  A 201 ( 1.3A)
PHE  A  85 ( 1.3A)
 1.26A 5igjA-1gc7A:
undetectable		 5igjA-1gc7A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1gc7 RADIXIN
(Mus
musculus) 		3 / 3 TYR A 201
ASP A 197
GLN A 196
 TYR  A 201 ( 1.3A)
ASP  A 197 ( 0.6A)
GLN  A 196 ( 0.6A)
 0.61A 6g1pA-1gc7A:
0.0		 6g1pA-1gc7A:
22.83