SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gcb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 102
ALA A  77
VAL A 419
TYR A 145
LEU A 263
 None
None
None
None
GOL  A 851 ( 4.9A)
 1.20A 1s9pB-1gcbA:
undetectable		 1s9pB-1gcbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		6 / 10 GLN A  67
GLY A  71
TRP A  74
PHE A  76
HIS A 369
ALA A 370
 HG  A 904 ( 4.8A)
HG  A 904 (-3.8A)
None
None
None
None
 0.58A 1stfE-1gcbA:
9.0
1stfI-1gcbA:
0.0		 1stfE-1gcbA:
19.63
1stfI-1gcbA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 412
TYR A 410
ARG A  44
ILE A 340
ASP A 339
 None
 1.00A 1t6zB-1gcbA:
undetectable		 1t6zB-1gcbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 288
GLY A 142
CYH A  73
ALA A 453
ALA A 370
 None
None
HG  A 904 ( 2.1A)
HG  A 904 (-4.8A)
None
 1.06A 2bm9D-1gcbA:
undetectable		 2bm9D-1gcbA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 288
GLY A 142
CYH A  73
ALA A 453
ALA A 370
 None
None
HG  A 904 ( 2.1A)
HG  A 904 (-4.8A)
None
 1.18A 2br4D-1gcbA:
undetectable		 2br4D-1gcbA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 261
GLY A 156
SER A 251
 None
 0.58A 2ivuA-1gcbA:
0.0		 2ivuA-1gcbA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  75
TRP A 176
MET A 220
LEU A 108
 None
 1.44A 2oz7A-1gcbA:
0.0		 2oz7A-1gcbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 102
LEU A 254
PHE A 148
 None
 0.65A 2pgrA-1gcbA:
undetectable		 2pgrA-1gcbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 195
ARG A 192
ALA A 194
ILE A 118
 None
SO4  A 802 (-3.8A)
None
None
 0.97A 2qhfA-1gcbA:
0.0		 2qhfA-1gcbA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		4 / 7 GLN A  67
GLY A  71
HIS A 369
TRP A 394
 HG  A 904 ( 4.8A)
HG  A 904 (-3.8A)
None
None
 0.36A 3ai8A-1gcbA:
13.5		 3ai8A-1gcbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 326
ILE A 360
TYR A 279
ASN A 301
GLU A 413
 None
 1.50A 4fglA-1gcbA:
undetectable
4fglB-1gcbA:
undetectable		 4fglA-1gcbA:
20.18
4fglB-1gcbA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 361
PRO A 448
ILE A 360
ASP A 274
 None
 1.38A 4z4hA-1gcbA:
0.8		 4z4hA-1gcbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 450
ALA A 451
PHE A 416
SER A 325
PHE A 322
 None
 1.18A 5cprB-1gcbA:
undetectable		 5cprB-1gcbA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 452
ALA A 453
LEU A 288
 None
HG  A 904 (-4.8A)
None
 0.53A 5uunB-1gcbA:
undetectable		 5uunB-1gcbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 398
MET A 331
TYR A 404
MET A 371
 None
 1.18A 5wqpA-1gcbA:
undetectable		 5wqpA-1gcbA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		3 / 3 SER A   8
LYS A   9
SER A  12
 None
 0.51A 6az3P-1gcbA:
0.0		 6az3P-1gcbA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		4 / 4 VAL A  64
GLY A 402
ASP A 401
ASP A 397
 None
None
None
SO4  A 801 ( 4.5A)
 1.46A 6cjkC-1gcbA:
undetectable		 6cjkC-1gcbA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1gcb GAL6 HG (EMTS)
DERIVATIVE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 185
ALA A 188
GLN A 132
ILE A 126
 None
None
None
SO4  A 802 (-3.7A)
 1.17A 6g9bA-1gcbA:
0.0
6g9bB-1gcbA:
0.0		 6g9bA-1gcbA:
11.45
6g9bB-1gcbA:
10.02