SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 1gco GLUCOSE
DEHYDROGENASE
(Bacillus
megaterium) 		4 / 7 SER A 101
MET A 104
LEU A 154
ILE A 195
 None
None
None
NAD  A 601 (-3.8A)
 1.09A 2bdmA-1gcoA:
undetectable		 2bdmA-1gcoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 1gco GLUCOSE
DEHYDROGENASE
(Bacillus
megaterium) 		5 / 12 GLY A 119
ASP A  65
GLY A  14
VAL A  76
VAL A  72
 None
NAD  A 601 (-3.4A)
NAD  A 601 (-3.8A)
None
None
 0.91A 2nnkB-1gcoA:
undetectable		 2nnkB-1gcoA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1gco GLUCOSE
DEHYDROGENASE
(Bacillus
megaterium) 		5 / 12 TYR A 158
ILE A 191
GLY A 189
ILE A 213
GLY A 219
 NAD  A 601 (-4.5A)
NAD  A 601 (-4.2A)
NAD  A 601 (-4.8A)
None
None
 0.96A 3bwcA-1gcoA:
5.6		 3bwcA-1gcoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1gco GLUCOSE
DEHYDROGENASE
(Bacillus
megaterium) 		5 / 12 TYR A 158
ILE A 191
GLY A 189
ILE A 213
GLY A 219
 NAD  A 601 (-4.5A)
NAD  A 601 (-4.2A)
NAD  A 601 (-4.8A)
None
None
 1.01A 3bwcB-1gcoA:
5.4		 3bwcB-1gcoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 1gco GLUCOSE
DEHYDROGENASE
(Bacillus
megaterium) 		3 / 3 ILE A  25
SER A  47
SER A  16
 None
None
NAD  A 601 ( 3.9A)
 0.60A 3iltH-1gcoA:
undetectable		 3iltH-1gcoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1gco GLUCOSE
DEHYDROGENASE
(Bacillus
megaterium) 		3 / 3 HIS A 147
GLU A  96
ASN A 196
 None
None
NAD  A 601 (-3.9A)
 0.94A 4bupB-1gcoA:
0.0		 4bupB-1gcoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 1gco GLUCOSE
DEHYDROGENASE
(Bacillus
megaterium) 		5 / 10 ALA A 159
TYR A 158
GLY A 187
SER A 161
GLY A 163
 None
NAD  A 601 (-4.5A)
None
None
None
 1.31A 4mmdA-1gcoA:
undetectable		 4mmdA-1gcoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 1gco GLUCOSE
DEHYDROGENASE
(Bacillus
megaterium) 		5 / 12 GLU A 210
PRO A 188
ARG A 206
GLU A 223
GLU A 220
 None
NAD  A 601 (-4.2A)
None
None
None
 1.39A 5mqtC-1gcoA:
2.8		 5mqtC-1gcoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1gco GLUCOSE
DEHYDROGENASE
(Bacillus
megaterium) 		3 / 3 HIS A 147
GLU A  96
ASN A 196
 None
None
NAD  A 601 (-3.9A)
 0.98A 5wbvA-1gcoA:
0.0		 5wbvA-1gcoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1gco GLUCOSE
DEHYDROGENASE
(Bacillus
megaterium) 		3 / 3 HIS A 147
GLU A  96
ASN A 196
 None
None
NAD  A 601 (-3.9A)
 0.99A 5wbvB-1gcoA:
0.0		 5wbvB-1gcoA:
20.95