SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 1gcw PROTEIN (HEMOGLOBIN)
(Mustelus
griseus) 		5 / 12 LEU A 109
GLU A 103
LEU A 128
ILE A  63
GLY A  25
 None
 1.10A 1g50B-1gcwA:
undetectable		 1g50B-1gcwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 1gcw PROTEIN (HEMOGLOBIN)
(Mustelus
griseus) 		5 / 11 LEU A 109
GLU A 103
LEU A 128
ILE A  63
GLY A  25
 None
 1.09A 1g50C-1gcwA:
0.0		 1g50C-1gcwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1gcw PROTEIN (HEMOGLOBIN)
(Mustelus
griseus) 		4 / 7 PHE B  42
PHE B  48
VAL B  57
HIS B  82
 HEM  B 136 (-3.6A)
None
HEM  B 136 (-4.1A)
HEM  B 136 (-3.5A)
 0.92A 1lh6A-1gcwB:
12.1		 1lh6A-1gcwB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1gcw PROTEIN (HEMOGLOBIN)
PROTEIN (HEMOGLOBIN)
(Mustelus
griseus;
Mustelus
griseus) 		5 / 12 LEU A 101
HIS A 121
ASP A 125
LEU B  95
ILE A 106
 HEM  A 141 (-4.4A)
None
None
None
None
 1.43A 1uobA-1gcwA:
undetectable		 1uobA-1gcwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1gcw PROTEIN (HEMOGLOBIN)
(Mustelus
griseus) 		3 / 3 LEU B  86
HIS B  82
LYS B  81
 HEM  B 136 (-4.0A)
HEM  B 136 (-3.5A)
HEM  B 136 ( 4.4A)
 1.06A 1y7iA-1gcwB:
undetectable		 1y7iA-1gcwB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 1gcw PROTEIN (HEMOGLOBIN)
(Mustelus
griseus) 		4 / 8 VAL A  57
GLY A  60
LYS A  61
PRO A  21
 None
 0.92A 3bjwA-1gcwA:
0.2		 3bjwA-1gcwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1gcw PROTEIN (HEMOGLOBIN)
(Mustelus
griseus) 		5 / 11 GLY A  25
GLY A  60
VAL A  55
HIS A  58
ALA A  50
 None
None
None
HEM  A 141 ( 4.0A)
None
 1.03A 3dxyA-1gcwA:
undetectable		 3dxyA-1gcwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1gcw PROTEIN (HEMOGLOBIN)
(Mustelus
griseus) 		5 / 12 ILE B 100
THR B  97
ILE B  11
GLU B   7
GLU B   6
 None
HEM  B 136 ( 4.6A)
None
None
None
 1.26A 4i41A-1gcwB:
undetectable		 4i41A-1gcwB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 1gcw PROTEIN (HEMOGLOBIN)
(Mustelus
griseus) 		4 / 5 PHE B  75
THR B  97
PHE B 123
ILE B 131
 None
HEM  B 136 ( 4.6A)
None
HEM  B 136 (-4.2A)
 1.25A 4jx1E-1gcwB:
0.9		 4jx1E-1gcwB:
15.58